Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis
The authors found that VDAC2 plays a crucial role in influencing mitochondrial calcium dynamics and cellular calcium signalling. A VDAC2 agonist, efsevin, rescued the heart failure phenotype, identifying a new potential therapeutic target for heart failure.
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Nature Portfolio
2021
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oai:doaj.org-article:5def0b8a41bf407088eed68a7df3942d2021-12-02T16:13:27ZCardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis10.1038/s41467-021-24869-02041-1723https://doaj.org/article/5def0b8a41bf407088eed68a7df3942d2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24869-0https://doaj.org/toc/2041-1723The authors found that VDAC2 plays a crucial role in influencing mitochondrial calcium dynamics and cellular calcium signalling. A VDAC2 agonist, efsevin, rescued the heart failure phenotype, identifying a new potential therapeutic target for heart failure.Thirupura S. ShankarDinesh K. A. RamaduraiKira SteinhorstSalah SommakiaRachit BadoliaAspasia Thodou KrokidiDallen CalderSutip NavankasattusasPaulina SanderOh Sung KwonAishwarya AravamudhanJing LingAndreas DendorferChangmin XieOhyun KwonEmily H. Y. ChengKevin J. WhiteheadThomas GudermannRussel S. RichardsonFrank B. SachseJohann SchredelsekerKenneth W. SpitzerDipayan ChaudhuriStavros G. DrakosNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
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Science Q Thirupura S. Shankar Dinesh K. A. Ramadurai Kira Steinhorst Salah Sommakia Rachit Badolia Aspasia Thodou Krokidi Dallen Calder Sutip Navankasattusas Paulina Sander Oh Sung Kwon Aishwarya Aravamudhan Jing Ling Andreas Dendorfer Changmin Xie Ohyun Kwon Emily H. Y. Cheng Kevin J. Whitehead Thomas Gudermann Russel S. Richardson Frank B. Sachse Johann Schredelseker Kenneth W. Spitzer Dipayan Chaudhuri Stavros G. Drakos Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis |
| description |
The authors found that VDAC2 plays a crucial role in influencing mitochondrial calcium dynamics and cellular calcium signalling. A VDAC2 agonist, efsevin, rescued the heart failure phenotype, identifying a new potential therapeutic target for heart failure. |
| format |
article |
| author |
Thirupura S. Shankar Dinesh K. A. Ramadurai Kira Steinhorst Salah Sommakia Rachit Badolia Aspasia Thodou Krokidi Dallen Calder Sutip Navankasattusas Paulina Sander Oh Sung Kwon Aishwarya Aravamudhan Jing Ling Andreas Dendorfer Changmin Xie Ohyun Kwon Emily H. Y. Cheng Kevin J. Whitehead Thomas Gudermann Russel S. Richardson Frank B. Sachse Johann Schredelseker Kenneth W. Spitzer Dipayan Chaudhuri Stavros G. Drakos |
| author_facet |
Thirupura S. Shankar Dinesh K. A. Ramadurai Kira Steinhorst Salah Sommakia Rachit Badolia Aspasia Thodou Krokidi Dallen Calder Sutip Navankasattusas Paulina Sander Oh Sung Kwon Aishwarya Aravamudhan Jing Ling Andreas Dendorfer Changmin Xie Ohyun Kwon Emily H. Y. Cheng Kevin J. Whitehead Thomas Gudermann Russel S. Richardson Frank B. Sachse Johann Schredelseker Kenneth W. Spitzer Dipayan Chaudhuri Stavros G. Drakos |
| author_sort |
Thirupura S. Shankar |
| title |
Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis |
| title_short |
Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis |
| title_full |
Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis |
| title_fullStr |
Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis |
| title_full_unstemmed |
Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis |
| title_sort |
cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/5def0b8a41bf407088eed68a7df3942d |
| work_keys_str_mv |
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