Case Report: Take a Second Look: Covid-19 Vaccination-Related Cerebral Venous Thrombosis and Thrombotic Thrombocytopenia Syndrome

We present two cases of ChAdOx1 nCov-19 (AstraZeneca)-associated thrombotic thrombocytopenia syndrome (TTS) and cerebral venous sinus thrombosis (CVST). At the time of emergency room presentation due to persistent headache, blood serum levels revealed reduced platelet counts. Yet, 1 or 4 days after...

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Autores principales:	Tobias Braun, Maxime Viard, Martin Juenemann, Tobias Struffert, Frank Schwarm, Hagen B. Huttner, Florian C. Roessler
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cerebral venous thrombosis Covid-19-vaccination ChAdOx1 nCoV-19 vaccine thrombotic thrombocytopenia syndrome vaccine-induced thrombotic thrombocytopenia Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/5df398532b1b47b78b74817879edab01
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spelling	oai:doaj.org-article:5df398532b1b47b78b74817879edab012021-11-22T05:09:18ZCase Report: Take a Second Look: Covid-19 Vaccination-Related Cerebral Venous Thrombosis and Thrombotic Thrombocytopenia Syndrome1664-229510.3389/fneur.2021.763049https://doaj.org/article/5df398532b1b47b78b74817879edab012021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.763049/fullhttps://doaj.org/toc/1664-2295We present two cases of ChAdOx1 nCov-19 (AstraZeneca)-associated thrombotic thrombocytopenia syndrome (TTS) and cerebral venous sinus thrombosis (CVST). At the time of emergency room presentation due to persistent headache, blood serum levels revealed reduced platelet counts. Yet, 1 or 4 days after the onset of the symptom, the first MR-angiography provided no evidence of CVST. Follow-up imaging, performed upon headache refractory to nonsteroidal pain medication verified CVST 2–10 days after initial negative MRI. Both the patients received combined treatment with intravenous immunoglobulins and parenteral anticoagulation leading to an increase of platelet concentration in both the individuals and resolution of the occluded cerebral sinus in one patient.Tobias BraunMaxime ViardMartin JuenemannTobias StruffertFrank SchwarmHagen B. HuttnerFlorian C. RoesslerFrontiers Media S.A.articlecerebral venous thrombosisCovid-19-vaccinationChAdOx1 nCoV-19 vaccinethrombotic thrombocytopenia syndromevaccine-induced thrombotic thrombocytopeniaNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cerebral venous thrombosis Covid-19-vaccination ChAdOx1 nCoV-19 vaccine thrombotic thrombocytopenia syndrome vaccine-induced thrombotic thrombocytopenia Neurology. Diseases of the nervous system RC346-429
spellingShingle	cerebral venous thrombosis Covid-19-vaccination ChAdOx1 nCoV-19 vaccine thrombotic thrombocytopenia syndrome vaccine-induced thrombotic thrombocytopenia Neurology. Diseases of the nervous system RC346-429 Tobias Braun Maxime Viard Martin Juenemann Tobias Struffert Frank Schwarm Hagen B. Huttner Florian C. Roessler Case Report: Take a Second Look: Covid-19 Vaccination-Related Cerebral Venous Thrombosis and Thrombotic Thrombocytopenia Syndrome
description	We present two cases of ChAdOx1 nCov-19 (AstraZeneca)-associated thrombotic thrombocytopenia syndrome (TTS) and cerebral venous sinus thrombosis (CVST). At the time of emergency room presentation due to persistent headache, blood serum levels revealed reduced platelet counts. Yet, 1 or 4 days after the onset of the symptom, the first MR-angiography provided no evidence of CVST. Follow-up imaging, performed upon headache refractory to nonsteroidal pain medication verified CVST 2–10 days after initial negative MRI. Both the patients received combined treatment with intravenous immunoglobulins and parenteral anticoagulation leading to an increase of platelet concentration in both the individuals and resolution of the occluded cerebral sinus in one patient.
format	article
author	Tobias Braun Maxime Viard Martin Juenemann Tobias Struffert Frank Schwarm Hagen B. Huttner Florian C. Roessler
author_facet	Tobias Braun Maxime Viard Martin Juenemann Tobias Struffert Frank Schwarm Hagen B. Huttner Florian C. Roessler
author_sort	Tobias Braun
title	Case Report: Take a Second Look: Covid-19 Vaccination-Related Cerebral Venous Thrombosis and Thrombotic Thrombocytopenia Syndrome
title_short	Case Report: Take a Second Look: Covid-19 Vaccination-Related Cerebral Venous Thrombosis and Thrombotic Thrombocytopenia Syndrome
title_full	Case Report: Take a Second Look: Covid-19 Vaccination-Related Cerebral Venous Thrombosis and Thrombotic Thrombocytopenia Syndrome
title_fullStr	Case Report: Take a Second Look: Covid-19 Vaccination-Related Cerebral Venous Thrombosis and Thrombotic Thrombocytopenia Syndrome
title_full_unstemmed	Case Report: Take a Second Look: Covid-19 Vaccination-Related Cerebral Venous Thrombosis and Thrombotic Thrombocytopenia Syndrome
title_sort	case report: take a second look: covid-19 vaccination-related cerebral venous thrombosis and thrombotic thrombocytopenia syndrome
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/5df398532b1b47b78b74817879edab01
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Case Report: Take a Second Look: Covid-19 Vaccination-Related Cerebral Venous Thrombosis and Thrombotic Thrombocytopenia Syndrome

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