Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus

Jun Xu, Lijun Cao, Yuan Suo, Xiaoqin Xu, Hui Sun, Songao Xu, Xiangyun Zhu, Huijie Yu, Weizhong Cao Department of Emergency Medicine, The First Hospital of Jiaxing, Jiaxing 314001, Zhejiang Province, China Background: The study of the experiment was to display the therapeutic function of insulin-lo...

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Autores principales:	Xu J, Cao L, Suo Y, Xu X, Sun H, Xu S, Zhu X, Yu H, Cao W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Insulin Chitosan;COX-2 VCAM-1 Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5df83a796b824890b02b68e7da6735bd
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spelling	oai:doaj.org-article:5df83a796b824890b02b68e7da6735bd2021-12-02T07:35:42ZChitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus1178-2013https://doaj.org/article/5df83a796b824890b02b68e7da6735bd2018-10-01T00:00:00Zhttps://www.dovepress.com/chitosan-microcapsulated-insulin-alleviates-mesenteric-microcirculatio-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jun Xu, Lijun Cao, Yuan Suo, Xiaoqin Xu, Hui Sun, Songao Xu, Xiangyun Zhu, Huijie Yu, Weizhong Cao Department of Emergency Medicine, The First Hospital of Jiaxing, Jiaxing 314001, Zhejiang Province, China Background: The study of the experiment was to display the therapeutic function of insulin-loaded chitosan (insulin/chitosan) on mesenteric microcirculation via down-regulating cyclooxygenase-2 (COX-2) and vascular cell adhesion molecule (VCAM-1) expressions in rats with diabetes mellitus (DM) as compared to free insulin. Methods: Diabetic rats were administrated with 24 U/kg insulin or 120 U/kg insulin/chitosan compounds. The blood and mesenteriums were collected, blood glucose levels, arteriole velocity, arteriole diameter, venular diameter, and hemodiapedesis were measured, and COX-2, VCAM-1 expressions were measured in mesenteriums tissues. Results: Both insulin and insulin/chitosan administration decreased blood glucose and improved the state of mesenteric microcirculation through down-regulating COX-2 and VCAM-1 expressions as compared to DM groups, while insulin/chitosan remarkably augmented this functions. Conclusion: Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expressions in rats with DM. Keywords: insulin, chitosan, COX-2, VCAM-1Xu JCao LSuo YXu XSun HXu SZhu XYu HCao WDove Medical PressarticleInsulinChitosan;COX-2VCAM-1Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 6829-6837 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Insulin Chitosan;COX-2 VCAM-1 Medicine (General) R5-920
spellingShingle	Insulin Chitosan;COX-2 VCAM-1 Medicine (General) R5-920 Xu J Cao L Suo Y Xu X Sun H Xu S Zhu X Yu H Cao W Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus
description	Jun Xu, Lijun Cao, Yuan Suo, Xiaoqin Xu, Hui Sun, Songao Xu, Xiangyun Zhu, Huijie Yu, Weizhong Cao Department of Emergency Medicine, The First Hospital of Jiaxing, Jiaxing 314001, Zhejiang Province, China Background: The study of the experiment was to display the therapeutic function of insulin-loaded chitosan (insulin/chitosan) on mesenteric microcirculation via down-regulating cyclooxygenase-2 (COX-2) and vascular cell adhesion molecule (VCAM-1) expressions in rats with diabetes mellitus (DM) as compared to free insulin. Methods: Diabetic rats were administrated with 24 U/kg insulin or 120 U/kg insulin/chitosan compounds. The blood and mesenteriums were collected, blood glucose levels, arteriole velocity, arteriole diameter, venular diameter, and hemodiapedesis were measured, and COX-2, VCAM-1 expressions were measured in mesenteriums tissues. Results: Both insulin and insulin/chitosan administration decreased blood glucose and improved the state of mesenteric microcirculation through down-regulating COX-2 and VCAM-1 expressions as compared to DM groups, while insulin/chitosan remarkably augmented this functions. Conclusion: Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expressions in rats with DM. Keywords: insulin, chitosan, COX-2, VCAM-1
format	article
author	Xu J Cao L Suo Y Xu X Sun H Xu S Zhu X Yu H Cao W
author_facet	Xu J Cao L Suo Y Xu X Sun H Xu S Zhu X Yu H Cao W
author_sort	Xu J
title	Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus
title_short	Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus
title_full	Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus
title_fullStr	Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus
title_full_unstemmed	Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus
title_sort	chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating cox-2 and vcam-1 expression in rats with diabetes mellitus
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/5df83a796b824890b02b68e7da6735bd
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Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus

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