Increased functional connectivity after stroke correlates with behavioral scores in non-human primate model

Abstract Here we characterized the functional connectivity (FC) changes occurring after a controlled MCA stroke in a primate model. We hypothesize that if FC can inform about the neural changes after a stroke in the non-human primate (NHP) stroke model, then significant FC changes after the stroke w...

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Autores principales:	Carlos R. Hernandez-Castillo, Joseph Y. Nashed, Juan Fernandez-Ruiz, Justin Wang, Jason Gallivan, Douglas J. Cook
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5dfe2f337b6c447b832d951b5ad58d0d
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spelling	oai:doaj.org-article:5dfe2f337b6c447b832d951b5ad58d0d2021-12-02T12:32:26ZIncreased functional connectivity after stroke correlates with behavioral scores in non-human primate model10.1038/s41598-017-07175-y2045-2322https://doaj.org/article/5dfe2f337b6c447b832d951b5ad58d0d2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07175-yhttps://doaj.org/toc/2045-2322Abstract Here we characterized the functional connectivity (FC) changes occurring after a controlled MCA stroke in a primate model. We hypothesize that if FC can inform about the neural changes after a stroke in the non-human primate (NHP) stroke model, then significant FC changes after the stroke would have to correlate with the remaining behavioral capacities. Eleven cynomolgus monkeys underwent an experimental middle cerebral artery occlusion while five monkeys remained as the control group. One month later the neurological function was assessed with a set of fine motor tasks and the Nonhuman Primate Stroke Scale (NHPSS). Structural and functional connectivity analyses were done to compare both groups. Three FC changes showed significant behavioral correlations: right sensorimotor-right lateral intraparietal FC with the six-well task; left posterior intraparietal-left dorsal premotor FC with the hill task; and right visual-left primary motor FC with the NHPSS. In the three instances, stronger FC correlated with better behavioral outcome. The results show that the functional changes correlating with behavioral outcomes involved sensorimotor cortices that were not restricted to the affected hemisphere. These results show that the FC analysis in NHP stroke model is a relevant methodology suitable to inform the neural changes occurring after a stroke.Carlos R. Hernandez-CastilloJoseph Y. NashedJuan Fernandez-RuizJustin WangJason GallivanDouglas J. CookNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carlos R. Hernandez-Castillo Joseph Y. Nashed Juan Fernandez-Ruiz Justin Wang Jason Gallivan Douglas J. Cook Increased functional connectivity after stroke correlates with behavioral scores in non-human primate model
description	Abstract Here we characterized the functional connectivity (FC) changes occurring after a controlled MCA stroke in a primate model. We hypothesize that if FC can inform about the neural changes after a stroke in the non-human primate (NHP) stroke model, then significant FC changes after the stroke would have to correlate with the remaining behavioral capacities. Eleven cynomolgus monkeys underwent an experimental middle cerebral artery occlusion while five monkeys remained as the control group. One month later the neurological function was assessed with a set of fine motor tasks and the Nonhuman Primate Stroke Scale (NHPSS). Structural and functional connectivity analyses were done to compare both groups. Three FC changes showed significant behavioral correlations: right sensorimotor-right lateral intraparietal FC with the six-well task; left posterior intraparietal-left dorsal premotor FC with the hill task; and right visual-left primary motor FC with the NHPSS. In the three instances, stronger FC correlated with better behavioral outcome. The results show that the functional changes correlating with behavioral outcomes involved sensorimotor cortices that were not restricted to the affected hemisphere. These results show that the FC analysis in NHP stroke model is a relevant methodology suitable to inform the neural changes occurring after a stroke.
format	article
author	Carlos R. Hernandez-Castillo Joseph Y. Nashed Juan Fernandez-Ruiz Justin Wang Jason Gallivan Douglas J. Cook
author_facet	Carlos R. Hernandez-Castillo Joseph Y. Nashed Juan Fernandez-Ruiz Justin Wang Jason Gallivan Douglas J. Cook
author_sort	Carlos R. Hernandez-Castillo
title	Increased functional connectivity after stroke correlates with behavioral scores in non-human primate model
title_short	Increased functional connectivity after stroke correlates with behavioral scores in non-human primate model
title_full	Increased functional connectivity after stroke correlates with behavioral scores in non-human primate model
title_fullStr	Increased functional connectivity after stroke correlates with behavioral scores in non-human primate model
title_full_unstemmed	Increased functional connectivity after stroke correlates with behavioral scores in non-human primate model
title_sort	increased functional connectivity after stroke correlates with behavioral scores in non-human primate model
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5dfe2f337b6c447b832d951b5ad58d0d
work_keys_str_mv	AT carlosrhernandezcastillo increasedfunctionalconnectivityafterstrokecorrelateswithbehavioralscoresinnonhumanprimatemodel AT josephynashed increasedfunctionalconnectivityafterstrokecorrelateswithbehavioralscoresinnonhumanprimatemodel AT juanfernandezruiz increasedfunctionalconnectivityafterstrokecorrelateswithbehavioralscoresinnonhumanprimatemodel AT justinwang increasedfunctionalconnectivityafterstrokecorrelateswithbehavioralscoresinnonhumanprimatemodel AT jasongallivan increasedfunctionalconnectivityafterstrokecorrelateswithbehavioralscoresinnonhumanprimatemodel AT douglasjcook increasedfunctionalconnectivityafterstrokecorrelateswithbehavioralscoresinnonhumanprimatemodel
_version_	1718394096708485120

Increased functional connectivity after stroke correlates with behavioral scores in non-human primate model

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