RhoT1 and Smad4 are correlated with lymph node metastasis and overall survival in pancreatic cancer.

Cancer cell invasion and metastasis are the most important adverse prognostic factors for pancreatic cancer. Identification of biomarkers associated with outcome of pancreatic cancer may provide new approaches and targets for anticancer therapy. The aim of this study is to examine the relationship b...

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Autores principales:	Hua Jiang, Chengzhi He, Shasha Geng, Haihui Sheng, Xiaoying Shen, Xiaoyan Zhang, Hang Li, Shizhang Zhu, Ximei Chen, Changqing Yang, HengJun Gao
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5e07287bdcb041a4b0577688f36b613a
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spelling	oai:doaj.org-article:5e07287bdcb041a4b0577688f36b613a2021-11-18T07:10:14ZRhoT1 and Smad4 are correlated with lymph node metastasis and overall survival in pancreatic cancer.1932-620310.1371/journal.pone.0042234https://doaj.org/article/5e07287bdcb041a4b0577688f36b613a2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22860091/?tool=EBIhttps://doaj.org/toc/1932-6203Cancer cell invasion and metastasis are the most important adverse prognostic factors for pancreatic cancer. Identification of biomarkers associated with outcome of pancreatic cancer may provide new approaches and targets for anticancer therapy. The aim of this study is to examine the relationship between the expression of RhoT1, Smad4 and p16 and metastasis and survival in patients with pancreatic cancer. The analysis showed that the high cytoplasmic expression levels of RhoT1, Smad4 and p16 in pancreatic cancer tissues had significantly negative correlation with lymph node metastasis (LNM) (P = 0.017, P = 0.032, P = 0.042, respectively). However, no significant association was observed between perineural invasion (PNI) and the expression of above three proteins (all P>0.05). Additionally, the survival analysis showed that the low expression levels of RhoT1 and Smad4 were significantly associated with worse survival (P = 0.034, P = 0.047, respectively). In conclusion, these results indicated that the low-expression levels of RhoT1 and Smad4 were significantly associated with LNM and shorter survival. RhoT1 may be considered as a potential novel marker for predicting the outcome in patients with pancreatic cancer.Hua JiangChengzhi HeShasha GengHaihui ShengXiaoying ShenXiaoyan ZhangHang LiShizhang ZhuXimei ChenChangqing YangHengJun GaoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e42234 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hua Jiang Chengzhi He Shasha Geng Haihui Sheng Xiaoying Shen Xiaoyan Zhang Hang Li Shizhang Zhu Ximei Chen Changqing Yang HengJun Gao RhoT1 and Smad4 are correlated with lymph node metastasis and overall survival in pancreatic cancer.
description	Cancer cell invasion and metastasis are the most important adverse prognostic factors for pancreatic cancer. Identification of biomarkers associated with outcome of pancreatic cancer may provide new approaches and targets for anticancer therapy. The aim of this study is to examine the relationship between the expression of RhoT1, Smad4 and p16 and metastasis and survival in patients with pancreatic cancer. The analysis showed that the high cytoplasmic expression levels of RhoT1, Smad4 and p16 in pancreatic cancer tissues had significantly negative correlation with lymph node metastasis (LNM) (P = 0.017, P = 0.032, P = 0.042, respectively). However, no significant association was observed between perineural invasion (PNI) and the expression of above three proteins (all P>0.05). Additionally, the survival analysis showed that the low expression levels of RhoT1 and Smad4 were significantly associated with worse survival (P = 0.034, P = 0.047, respectively). In conclusion, these results indicated that the low-expression levels of RhoT1 and Smad4 were significantly associated with LNM and shorter survival. RhoT1 may be considered as a potential novel marker for predicting the outcome in patients with pancreatic cancer.
format	article
author	Hua Jiang Chengzhi He Shasha Geng Haihui Sheng Xiaoying Shen Xiaoyan Zhang Hang Li Shizhang Zhu Ximei Chen Changqing Yang HengJun Gao
author_facet	Hua Jiang Chengzhi He Shasha Geng Haihui Sheng Xiaoying Shen Xiaoyan Zhang Hang Li Shizhang Zhu Ximei Chen Changqing Yang HengJun Gao
author_sort	Hua Jiang
title	RhoT1 and Smad4 are correlated with lymph node metastasis and overall survival in pancreatic cancer.
title_short	RhoT1 and Smad4 are correlated with lymph node metastasis and overall survival in pancreatic cancer.
title_full	RhoT1 and Smad4 are correlated with lymph node metastasis and overall survival in pancreatic cancer.
title_fullStr	RhoT1 and Smad4 are correlated with lymph node metastasis and overall survival in pancreatic cancer.
title_full_unstemmed	RhoT1 and Smad4 are correlated with lymph node metastasis and overall survival in pancreatic cancer.
title_sort	rhot1 and smad4 are correlated with lymph node metastasis and overall survival in pancreatic cancer.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/5e07287bdcb041a4b0577688f36b613a
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RhoT1 and Smad4 are correlated with lymph node metastasis and overall survival in pancreatic cancer.

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