KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition

Previous studies have highlighted a paradoxical role of perisomatic-targeting parvalbumin-positive (PV+) interneurons in ictogenesis. Here, authors used an acute in vivo model of focal cortical seizures in awake behaving mice to show that photo-depolarization of PV+ interneurons rapidly switches fro...

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Autores principales:	Vincent Magloire, Jonathan Cornford, Andreas Lieb, Dimitri M. Kullmann, Ivan Pavlov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5e0876845b4641cc849597ff58d14784
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spelling	oai:doaj.org-article:5e0876845b4641cc849597ff58d147842021-12-02T15:35:08ZKCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition10.1038/s41467-019-08933-42041-1723https://doaj.org/article/5e0876845b4641cc849597ff58d147842019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08933-4https://doaj.org/toc/2041-1723Previous studies have highlighted a paradoxical role of perisomatic-targeting parvalbumin-positive (PV+) interneurons in ictogenesis. Here, authors used an acute in vivo model of focal cortical seizures in awake behaving mice to show that photo-depolarization of PV+ interneurons rapidly switches from an anti-ictal to a pro-ictal effect within a few seconds of seizure initiation, and that this switch can be prevented by overexpression of the neuronal potassium-chloride co-transporter KCC2 in principal cortical neurons.Vincent MagloireJonathan CornfordAndreas LiebDimitri M. KullmannIvan PavlovNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vincent Magloire Jonathan Cornford Andreas Lieb Dimitri M. Kullmann Ivan Pavlov KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition
description	Previous studies have highlighted a paradoxical role of perisomatic-targeting parvalbumin-positive (PV+) interneurons in ictogenesis. Here, authors used an acute in vivo model of focal cortical seizures in awake behaving mice to show that photo-depolarization of PV+ interneurons rapidly switches from an anti-ictal to a pro-ictal effect within a few seconds of seizure initiation, and that this switch can be prevented by overexpression of the neuronal potassium-chloride co-transporter KCC2 in principal cortical neurons.
format	article
author	Vincent Magloire Jonathan Cornford Andreas Lieb Dimitri M. Kullmann Ivan Pavlov
author_facet	Vincent Magloire Jonathan Cornford Andreas Lieb Dimitri M. Kullmann Ivan Pavlov
author_sort	Vincent Magloire
title	KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition
title_short	KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition
title_full	KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition
title_fullStr	KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition
title_full_unstemmed	KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition
title_sort	kcc2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5e0876845b4641cc849597ff58d14784
work_keys_str_mv	AT vincentmagloire kcc2overexpressionpreventstheparadoxicalseizurepromotingactionofsomaticinhibition AT jonathancornford kcc2overexpressionpreventstheparadoxicalseizurepromotingactionofsomaticinhibition AT andreaslieb kcc2overexpressionpreventstheparadoxicalseizurepromotingactionofsomaticinhibition AT dimitrimkullmann kcc2overexpressionpreventstheparadoxicalseizurepromotingactionofsomaticinhibition AT ivanpavlov kcc2overexpressionpreventstheparadoxicalseizurepromotingactionofsomaticinhibition
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KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition

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