KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition
Previous studies have highlighted a paradoxical role of perisomatic-targeting parvalbumin-positive (PV+) interneurons in ictogenesis. Here, authors used an acute in vivo model of focal cortical seizures in awake behaving mice to show that photo-depolarization of PV+ interneurons rapidly switches fro...
Guardado en:
Autores principales: | Vincent Magloire, Jonathan Cornford, Andreas Lieb, Dimitri M. Kullmann, Ivan Pavlov |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
|
Materias: | |
Acceso en línea: | https://doaj.org/article/5e0876845b4641cc849597ff58d14784 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
KCC2 downregulation facilitates epileptic seizures
por: Lulan Chen, et al.
Publicado: (2017) -
Focal cortical seizures start as standing waves and propagate respecting homotopic connectivity
por: L. Federico Rossi, et al.
Publicado: (2017) -
Overexpressed somatic alleles are enriched in functional elements in Breast Cancer
por: Paula Restrepo, et al.
Publicado: (2017) -
Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination
por: Kathrin Gödde, et al.
Publicado: (2016) -
Enhancing KCC2 function counteracts morphine-induced hyperalgesia
por: Francesco Ferrini, et al.
Publicado: (2017)