Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome
Germline mutations in the DNMT3A gene can cause an overgrowth syndrome associated with behavioural and hematopoietic phenotypes. Here the authors describe a mouse model of this syndrome that recapitulates many of these features, including conserved alterations in DNA methylation in the blood cells o...
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Nature Portfolio
2021
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oai:doaj.org-article:5e0d8e3763324ed0920eb1d6b6fbeadf2021-12-02T16:31:04ZFunctional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome10.1038/s41467-021-24800-72041-1723https://doaj.org/article/5e0d8e3763324ed0920eb1d6b6fbeadf2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24800-7https://doaj.org/toc/2041-1723Germline mutations in the DNMT3A gene can cause an overgrowth syndrome associated with behavioural and hematopoietic phenotypes. Here the authors describe a mouse model of this syndrome that recapitulates many of these features, including conserved alterations in DNA methylation in the blood cells of both species.Amanda M. SmithTaylor A. LaValleMarwan ShinawiSai M. RamakrishnanHaley J. AbelCheryl A. HillNicole M. KirklandMichael P. RettigNichole M. HeltonSharon E. HeathFrancesca FerraroDavid Y. ChenSangeeta AdakClay F. SemenkovichDiana L. ChristianJenna R. MartinHarrison W. GabelChristopher A. MillerTimothy J. LeyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Amanda M. Smith Taylor A. LaValle Marwan Shinawi Sai M. Ramakrishnan Haley J. Abel Cheryl A. Hill Nicole M. Kirkland Michael P. Rettig Nichole M. Helton Sharon E. Heath Francesca Ferraro David Y. Chen Sangeeta Adak Clay F. Semenkovich Diana L. Christian Jenna R. Martin Harrison W. Gabel Christopher A. Miller Timothy J. Ley Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome |
| description |
Germline mutations in the DNMT3A gene can cause an overgrowth syndrome associated with behavioural and hematopoietic phenotypes. Here the authors describe a mouse model of this syndrome that recapitulates many of these features, including conserved alterations in DNA methylation in the blood cells of both species. |
| format |
article |
| author |
Amanda M. Smith Taylor A. LaValle Marwan Shinawi Sai M. Ramakrishnan Haley J. Abel Cheryl A. Hill Nicole M. Kirkland Michael P. Rettig Nichole M. Helton Sharon E. Heath Francesca Ferraro David Y. Chen Sangeeta Adak Clay F. Semenkovich Diana L. Christian Jenna R. Martin Harrison W. Gabel Christopher A. Miller Timothy J. Ley |
| author_facet |
Amanda M. Smith Taylor A. LaValle Marwan Shinawi Sai M. Ramakrishnan Haley J. Abel Cheryl A. Hill Nicole M. Kirkland Michael P. Rettig Nichole M. Helton Sharon E. Heath Francesca Ferraro David Y. Chen Sangeeta Adak Clay F. Semenkovich Diana L. Christian Jenna R. Martin Harrison W. Gabel Christopher A. Miller Timothy J. Ley |
| author_sort |
Amanda M. Smith |
| title |
Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome |
| title_short |
Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome |
| title_full |
Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome |
| title_fullStr |
Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome |
| title_full_unstemmed |
Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome |
| title_sort |
functional and epigenetic phenotypes of humans and mice with dnmt3a overgrowth syndrome |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/5e0d8e3763324ed0920eb1d6b6fbeadf |
| work_keys_str_mv |
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