Insomnia with physiological hyperarousal is associated with lower weight: a novel finding and its clinical implications

Abstract Previous studies on the association of insomnia with body mass index (BMI) have been controversial. Physiological hyperarousal, the key pathological mechanism of insomnia, may be an important reason for different findings. We explored whether insomnia with physiological hyperarousal measure...

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Autores principales:	Rong Ren, Ye Zhang, Linghui Yang, Larry D. Sanford, Xiangdong Tang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/5e0f3e2c09f146d49d52243fd097662f
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spelling	oai:doaj.org-article:5e0f3e2c09f146d49d52243fd097662f2021-11-28T12:09:23ZInsomnia with physiological hyperarousal is associated with lower weight: a novel finding and its clinical implications10.1038/s41398-021-01672-52158-3188https://doaj.org/article/5e0f3e2c09f146d49d52243fd097662f2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41398-021-01672-5https://doaj.org/toc/2158-3188Abstract Previous studies on the association of insomnia with body mass index (BMI) have been controversial. Physiological hyperarousal, the key pathological mechanism of insomnia, may be an important reason for different findings. We explored whether insomnia with physiological hyperarousal measured by the multiple sleep latency test (MSLT) is associated with body-weight differences. A total of 185 normal sleepers and 440 insomniacs were included in this study. Insomnia was defined by standard diagnostic criteria with symptoms lasting ≥6 months. All subjects underwent one night of laboratory polysomnography followed by a standard MSLT. We used the median MSLT value (i.e., ≥14 min) to define physiological hyperarousal. BMI was based on measured height (cm) and weight (kg) during the subjects’ sleep laboratory visit. BMI > 25 kg/m2 was defined as overweight, while BMI < 18.5 kg/m2 was defined as underweight. After controlling for confounders, the odds of lower weight rather than overweight were significantly increased among insomnia patients with increased MSLT: insomnia with MSLT 14–17 min and MSLT > 17 min increased the odds of lower weight by approximately 89% (OR = 1.89, 95% CI 1.00–4.85) and 273% (OR = 3.73, 95% CI 1.51–9.22) compared with normal sleepers, respectively. In contrast, insomnia in patients with MSLT 11–14 min and 8–11 min was not different from normal sleepers in terms of body weight. Insomnia associated with physiological hyperarousal, the most severe phenotype of chronic insomnia, is associated with higher odds of lower weight and underweight compared with normal sleepers. This is a novel finding consistent with previous physiologic data and has significant clinical implications.Rong RenYe ZhangLinghui YangLarry D. SanfordXiangdong TangNature Publishing GrouparticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Psychiatry, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Rong Ren Ye Zhang Linghui Yang Larry D. Sanford Xiangdong Tang Insomnia with physiological hyperarousal is associated with lower weight: a novel finding and its clinical implications
description	Abstract Previous studies on the association of insomnia with body mass index (BMI) have been controversial. Physiological hyperarousal, the key pathological mechanism of insomnia, may be an important reason for different findings. We explored whether insomnia with physiological hyperarousal measured by the multiple sleep latency test (MSLT) is associated with body-weight differences. A total of 185 normal sleepers and 440 insomniacs were included in this study. Insomnia was defined by standard diagnostic criteria with symptoms lasting ≥6 months. All subjects underwent one night of laboratory polysomnography followed by a standard MSLT. We used the median MSLT value (i.e., ≥14 min) to define physiological hyperarousal. BMI was based on measured height (cm) and weight (kg) during the subjects’ sleep laboratory visit. BMI > 25 kg/m2 was defined as overweight, while BMI < 18.5 kg/m2 was defined as underweight. After controlling for confounders, the odds of lower weight rather than overweight were significantly increased among insomnia patients with increased MSLT: insomnia with MSLT 14–17 min and MSLT > 17 min increased the odds of lower weight by approximately 89% (OR = 1.89, 95% CI 1.00–4.85) and 273% (OR = 3.73, 95% CI 1.51–9.22) compared with normal sleepers, respectively. In contrast, insomnia in patients with MSLT 11–14 min and 8–11 min was not different from normal sleepers in terms of body weight. Insomnia associated with physiological hyperarousal, the most severe phenotype of chronic insomnia, is associated with higher odds of lower weight and underweight compared with normal sleepers. This is a novel finding consistent with previous physiologic data and has significant clinical implications.
format	article
author	Rong Ren Ye Zhang Linghui Yang Larry D. Sanford Xiangdong Tang
author_facet	Rong Ren Ye Zhang Linghui Yang Larry D. Sanford Xiangdong Tang
author_sort	Rong Ren
title	Insomnia with physiological hyperarousal is associated with lower weight: a novel finding and its clinical implications
title_short	Insomnia with physiological hyperarousal is associated with lower weight: a novel finding and its clinical implications
title_full	Insomnia with physiological hyperarousal is associated with lower weight: a novel finding and its clinical implications
title_fullStr	Insomnia with physiological hyperarousal is associated with lower weight: a novel finding and its clinical implications
title_full_unstemmed	Insomnia with physiological hyperarousal is associated with lower weight: a novel finding and its clinical implications
title_sort	insomnia with physiological hyperarousal is associated with lower weight: a novel finding and its clinical implications
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/5e0f3e2c09f146d49d52243fd097662f
work_keys_str_mv	AT rongren insomniawithphysiologicalhyperarousalisassociatedwithlowerweightanovelfindinganditsclinicalimplications AT yezhang insomniawithphysiologicalhyperarousalisassociatedwithlowerweightanovelfindinganditsclinicalimplications AT linghuiyang insomniawithphysiologicalhyperarousalisassociatedwithlowerweightanovelfindinganditsclinicalimplications AT larrydsanford insomniawithphysiologicalhyperarousalisassociatedwithlowerweightanovelfindinganditsclinicalimplications AT xiangdongtang insomniawithphysiologicalhyperarousalisassociatedwithlowerweightanovelfindinganditsclinicalimplications
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Insomnia with physiological hyperarousal is associated with lower weight: a novel finding and its clinical implications

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