Effect of Trianthema portulacastrum extracts on hematologic and hepatic enzymes disorders induced by carbon tetrachloride in rabbits (Oryctolagus cuniculus)

The study evaluated therapeutic effects of aqueous and ethanolic extracts of Trianthema portulacastrum against carbon tetrachloride (CCl4) induced toxicity in rabbits. The entire sample plant was identified using key, dried, ground, and bioactive compounds were extracted using Soxhlet extractor. Adu...

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Autores principales:	Kashif Ali, Syed Mohsin Bukhari, Khalil ur-Rehman, Iram Maqsood, Muhammad Asad, Asia Iqbal, Nimra Khalid, Shahla Andleeb, Huda Ahmed Alghamdi, Tahira Ruby
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	ccl4 intoxication hematological abnormalities oryctolagus cuniculus silymarin trianthema portulacastrum Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/5e10c6483ac440f890ba23c83aa0fd97
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spelling	oai:doaj.org-article:5e10c6483ac440f890ba23c83aa0fd972021-12-01T14:40:59ZEffect of Trianthema portulacastrum extracts on hematologic and hepatic enzymes disorders induced by carbon tetrachloride in rabbits (Oryctolagus cuniculus)1658-365510.1080/16583655.2021.2009679https://doaj.org/article/5e10c6483ac440f890ba23c83aa0fd972021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/16583655.2021.2009679https://doaj.org/toc/1658-3655The study evaluated therapeutic effects of aqueous and ethanolic extracts of Trianthema portulacastrum against carbon tetrachloride (CCl4) induced toxicity in rabbits. The entire sample plant was identified using key, dried, ground, and bioactive compounds were extracted using Soxhlet extractor. Adult rabbits (N = 60, 1 kg body weight) were divided into 5 groups: group I as controls, group II received CCl4 only, groups III to V received CCl4 in normal saline but were later orally administered different doses (75, 150 and 225 mg kg−1) of silymarin , aqueous or ethanolic extracts of T. portulacastrum. Hematological parameters were investigated 6 days after administration of the ameliorants. The effects of T. portulacastrum ethanolic and aqueous extracts were then compared to effects of standard silymarin drug. It was discovered that ethanolic extracts conferred hepato-protection on rabbits as silymarin did, suggesting that these extracts may be used instead of silymarin to improve animals health exposed to toxicity.Kashif AliSyed Mohsin BukhariKhalil ur-RehmanIram MaqsoodMuhammad AsadAsia IqbalNimra KhalidShahla AndleebHuda Ahmed AlghamdiTahira RubyTaylor & Francis Grouparticleccl4 intoxicationhematological abnormalitiesoryctolagus cuniculussilymarintrianthema portulacastrumScience (General)Q1-390ENJournal of Taibah University for Science, Vol 15, Iss 1, Pp 896-901 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ccl4 intoxication hematological abnormalities oryctolagus cuniculus silymarin trianthema portulacastrum Science (General) Q1-390
spellingShingle	ccl4 intoxication hematological abnormalities oryctolagus cuniculus silymarin trianthema portulacastrum Science (General) Q1-390 Kashif Ali Syed Mohsin Bukhari Khalil ur-Rehman Iram Maqsood Muhammad Asad Asia Iqbal Nimra Khalid Shahla Andleeb Huda Ahmed Alghamdi Tahira Ruby Effect of Trianthema portulacastrum extracts on hematologic and hepatic enzymes disorders induced by carbon tetrachloride in rabbits (Oryctolagus cuniculus)
description	The study evaluated therapeutic effects of aqueous and ethanolic extracts of Trianthema portulacastrum against carbon tetrachloride (CCl4) induced toxicity in rabbits. The entire sample plant was identified using key, dried, ground, and bioactive compounds were extracted using Soxhlet extractor. Adult rabbits (N = 60, 1 kg body weight) were divided into 5 groups: group I as controls, group II received CCl4 only, groups III to V received CCl4 in normal saline but were later orally administered different doses (75, 150 and 225 mg kg−1) of silymarin , aqueous or ethanolic extracts of T. portulacastrum. Hematological parameters were investigated 6 days after administration of the ameliorants. The effects of T. portulacastrum ethanolic and aqueous extracts were then compared to effects of standard silymarin drug. It was discovered that ethanolic extracts conferred hepato-protection on rabbits as silymarin did, suggesting that these extracts may be used instead of silymarin to improve animals health exposed to toxicity.
format	article
author	Kashif Ali Syed Mohsin Bukhari Khalil ur-Rehman Iram Maqsood Muhammad Asad Asia Iqbal Nimra Khalid Shahla Andleeb Huda Ahmed Alghamdi Tahira Ruby
author_facet	Kashif Ali Syed Mohsin Bukhari Khalil ur-Rehman Iram Maqsood Muhammad Asad Asia Iqbal Nimra Khalid Shahla Andleeb Huda Ahmed Alghamdi Tahira Ruby
author_sort	Kashif Ali
title	Effect of Trianthema portulacastrum extracts on hematologic and hepatic enzymes disorders induced by carbon tetrachloride in rabbits (Oryctolagus cuniculus)
title_short	Effect of Trianthema portulacastrum extracts on hematologic and hepatic enzymes disorders induced by carbon tetrachloride in rabbits (Oryctolagus cuniculus)
title_full	Effect of Trianthema portulacastrum extracts on hematologic and hepatic enzymes disorders induced by carbon tetrachloride in rabbits (Oryctolagus cuniculus)
title_fullStr	Effect of Trianthema portulacastrum extracts on hematologic and hepatic enzymes disorders induced by carbon tetrachloride in rabbits (Oryctolagus cuniculus)
title_full_unstemmed	Effect of Trianthema portulacastrum extracts on hematologic and hepatic enzymes disorders induced by carbon tetrachloride in rabbits (Oryctolagus cuniculus)
title_sort	effect of trianthema portulacastrum extracts on hematologic and hepatic enzymes disorders induced by carbon tetrachloride in rabbits (oryctolagus cuniculus)
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/5e10c6483ac440f890ba23c83aa0fd97
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Effect of Trianthema portulacastrum extracts on hematologic and hepatic enzymes disorders induced by carbon tetrachloride in rabbits (Oryctolagus cuniculus)

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