Redox Regulation and Oxidative Stress in Mammalian Oocytes and Embryos Developed In Vivo and In Vitro

Oocytes and preimplantation embryos require careful regulation of the redox environment for optimal development both in vivo and in vitro. Reactive oxygen species (ROS) are generated throughout development as a result of cellular metabolism and enzyme reactions....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Madeleine L. M. Hardy, Margot L. Day, Michael B. Morris
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	redox ROS embryo oocyte antioxidants assisted reproductive technology Medicine R
Acceso en línea:	https://doaj.org/article/5e14d615585a4c648d81fafc900d61d0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5e14d615585a4c648d81fafc900d61d0
record_format	dspace
spelling	oai:doaj.org-article:5e14d615585a4c648d81fafc900d61d02021-11-11T16:29:54ZRedox Regulation and Oxidative Stress in Mammalian Oocytes and Embryos Developed <i>In Vivo</i> and <i>In Vitro</i>10.3390/ijerph1821113741660-46011661-7827https://doaj.org/article/5e14d615585a4c648d81fafc900d61d02021-10-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/21/11374https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Oocytes and preimplantation embryos require careful regulation of the redox environment for optimal development both <i>in vivo</i> and <i>in vitro</i>. Reactive oxygen species (ROS) are generated throughout development as a result of cellular metabolism and enzyme reactions. ROS production can result in (i) oxidative eustress, where ROS are helpful signalling molecules with beneficial physiological functions and where the redox state of the cell is maintained within homeostatic range by a closely coupled system of antioxidants and antioxidant enzymes, or (ii) oxidative distress, where excess ROS are deleterious and impair normal cellular function. <i>in vitro</i> culture of embryos exacerbates ROS production due to a range of issues including culture-medium composition and laboratory culture conditions. This increase in ROS can be detrimental not only to assisted reproductive success rates but can also result in epigenetic and genetic changes in the embryo, resulting in transgenerational effects. This review examines the effects of oxidative stress in the oocyte and preimplantation embryo in both the <i>in vivo</i> and <i>in vitro</i> environment, identifies mechanisms responsible for oxidative stress in the oocyte/embryo in culture and approaches to reduce these problems, and briefly examines the potential impacts on future generations.Madeleine L. M. HardyMargot L. DayMichael B. MorrisMDPI AGarticleredoxROSembryooocyteantioxidantsassisted reproductive technologyMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11374, p 11374 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	redox ROS embryo oocyte antioxidants assisted reproductive technology Medicine R
spellingShingle	redox ROS embryo oocyte antioxidants assisted reproductive technology Medicine R Madeleine L. M. Hardy Margot L. Day Michael B. Morris Redox Regulation and Oxidative Stress in Mammalian Oocytes and Embryos Developed <i>In Vivo</i> and <i>In Vitro</i>
description	Oocytes and preimplantation embryos require careful regulation of the redox environment for optimal development both <i>in vivo</i> and <i>in vitro</i>. Reactive oxygen species (ROS) are generated throughout development as a result of cellular metabolism and enzyme reactions. ROS production can result in (i) oxidative eustress, where ROS are helpful signalling molecules with beneficial physiological functions and where the redox state of the cell is maintained within homeostatic range by a closely coupled system of antioxidants and antioxidant enzymes, or (ii) oxidative distress, where excess ROS are deleterious and impair normal cellular function. <i>in vitro</i> culture of embryos exacerbates ROS production due to a range of issues including culture-medium composition and laboratory culture conditions. This increase in ROS can be detrimental not only to assisted reproductive success rates but can also result in epigenetic and genetic changes in the embryo, resulting in transgenerational effects. This review examines the effects of oxidative stress in the oocyte and preimplantation embryo in both the <i>in vivo</i> and <i>in vitro</i> environment, identifies mechanisms responsible for oxidative stress in the oocyte/embryo in culture and approaches to reduce these problems, and briefly examines the potential impacts on future generations.
format	article
author	Madeleine L. M. Hardy Margot L. Day Michael B. Morris
author_facet	Madeleine L. M. Hardy Margot L. Day Michael B. Morris
author_sort	Madeleine L. M. Hardy
title	Redox Regulation and Oxidative Stress in Mammalian Oocytes and Embryos Developed <i>In Vivo</i> and <i>In Vitro</i>
title_short	Redox Regulation and Oxidative Stress in Mammalian Oocytes and Embryos Developed <i>In Vivo</i> and <i>In Vitro</i>
title_full	Redox Regulation and Oxidative Stress in Mammalian Oocytes and Embryos Developed <i>In Vivo</i> and <i>In Vitro</i>
title_fullStr	Redox Regulation and Oxidative Stress in Mammalian Oocytes and Embryos Developed <i>In Vivo</i> and <i>In Vitro</i>
title_full_unstemmed	Redox Regulation and Oxidative Stress in Mammalian Oocytes and Embryos Developed <i>In Vivo</i> and <i>In Vitro</i>
title_sort	redox regulation and oxidative stress in mammalian oocytes and embryos developed <i>in vivo</i> and <i>in vitro</i>
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5e14d615585a4c648d81fafc900d61d0
work_keys_str_mv	AT madeleinelmhardy redoxregulationandoxidativestressinmammalianoocytesandembryosdevelopediinvivoiandiinvitroi AT margotlday redoxregulationandoxidativestressinmammalianoocytesandembryosdevelopediinvivoiandiinvitroi AT michaelbmorris redoxregulationandoxidativestressinmammalianoocytesandembryosdevelopediinvivoiandiinvitroi
_version_	1718432298745987072

Redox Regulation and Oxidative Stress in Mammalian Oocytes and Embryos Developed <i>In Vivo</i> and <i>In Vitro</i>

Ejemplares similares