Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer’s Disease

Mitochondrial dysfunction including deficits of mitophagy is seen in aging and neurodegenerative disorders including Alzheimer’s disease (AD). Apart from traditionally targeting amyloid beta (Aβ), the main culprit in AD brains, other approaches include investigating impaired mitochondrial pathways f...

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Autores principales:	Dona Pamoda W. Jayatunga, Eugene Hone, Harjot Khaira, Taciana Lunelli, Harjinder Singh, Gilles J. Guillemin, Binosha Fernando, Manohar L. Garg, Giuseppe Verdile, Ralph N. Martins
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Alzheimer’s disease mitophagy neuroprotection nutraceuticals pomegranate urolithin A Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/5e15ca78a9d14bd2becf90e992527d94
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spelling	oai:doaj.org-article:5e15ca78a9d14bd2becf90e992527d942021-11-25T18:33:41ZTherapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer’s Disease10.3390/nu131137442072-6643https://doaj.org/article/5e15ca78a9d14bd2becf90e992527d942021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3744https://doaj.org/toc/2072-6643Mitochondrial dysfunction including deficits of mitophagy is seen in aging and neurodegenerative disorders including Alzheimer’s disease (AD). Apart from traditionally targeting amyloid beta (Aβ), the main culprit in AD brains, other approaches include investigating impaired mitochondrial pathways for potential therapeutic benefits against AD. Thus, a future therapy for AD may focus on novel candidates that enhance optimal mitochondrial integrity and turnover. Bioactive food components, known as nutraceuticals, may serve as such agents to combat AD. Urolithin A is an intestinal microbe-derived metabolite of a class of polyphenols, ellagitannins (ETs). Urolithin A is known to exert many health benefits. Its antioxidant, anti-inflammatory, anti-atherogenic, anti-Aβ, and pro-mitophagy properties are increasingly recognized. However, the underlying mechanisms of urolithin A in inducing mitophagy is poorly understood. This review discusses the mitophagy deficits in AD and examines potential molecular mechanisms of its activation. Moreover, the current knowledge of urolithin A is discussed, focusing on its neuroprotective properties and its potential to induce mitophagy. Specifically, this review proposes potential mechanisms by which urolithin A may activate and promote mitophagy.Dona Pamoda W. JayatungaEugene HoneHarjot KhairaTaciana LunelliHarjinder SinghGilles J. GuilleminBinosha FernandoManohar L. GargGiuseppe VerdileRalph N. MartinsMDPI AGarticleAlzheimer’s diseasemitophagyneuroprotectionnutraceuticalspomegranateurolithin ANutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3744, p 3744 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alzheimer’s disease mitophagy neuroprotection nutraceuticals pomegranate urolithin A Nutrition. Foods and food supply TX341-641
spellingShingle	Alzheimer’s disease mitophagy neuroprotection nutraceuticals pomegranate urolithin A Nutrition. Foods and food supply TX341-641 Dona Pamoda W. Jayatunga Eugene Hone Harjot Khaira Taciana Lunelli Harjinder Singh Gilles J. Guillemin Binosha Fernando Manohar L. Garg Giuseppe Verdile Ralph N. Martins Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer’s Disease
description	Mitochondrial dysfunction including deficits of mitophagy is seen in aging and neurodegenerative disorders including Alzheimer’s disease (AD). Apart from traditionally targeting amyloid beta (Aβ), the main culprit in AD brains, other approaches include investigating impaired mitochondrial pathways for potential therapeutic benefits against AD. Thus, a future therapy for AD may focus on novel candidates that enhance optimal mitochondrial integrity and turnover. Bioactive food components, known as nutraceuticals, may serve as such agents to combat AD. Urolithin A is an intestinal microbe-derived metabolite of a class of polyphenols, ellagitannins (ETs). Urolithin A is known to exert many health benefits. Its antioxidant, anti-inflammatory, anti-atherogenic, anti-Aβ, and pro-mitophagy properties are increasingly recognized. However, the underlying mechanisms of urolithin A in inducing mitophagy is poorly understood. This review discusses the mitophagy deficits in AD and examines potential molecular mechanisms of its activation. Moreover, the current knowledge of urolithin A is discussed, focusing on its neuroprotective properties and its potential to induce mitophagy. Specifically, this review proposes potential mechanisms by which urolithin A may activate and promote mitophagy.
format	article
author	Dona Pamoda W. Jayatunga Eugene Hone Harjot Khaira Taciana Lunelli Harjinder Singh Gilles J. Guillemin Binosha Fernando Manohar L. Garg Giuseppe Verdile Ralph N. Martins
author_facet	Dona Pamoda W. Jayatunga Eugene Hone Harjot Khaira Taciana Lunelli Harjinder Singh Gilles J. Guillemin Binosha Fernando Manohar L. Garg Giuseppe Verdile Ralph N. Martins
author_sort	Dona Pamoda W. Jayatunga
title	Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer’s Disease
title_short	Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer’s Disease
title_full	Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer’s Disease
title_fullStr	Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer’s Disease
title_full_unstemmed	Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer’s Disease
title_sort	therapeutic potential of mitophagy-inducing microflora metabolite, urolithin a for alzheimer’s disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5e15ca78a9d14bd2becf90e992527d94
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Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer’s Disease

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