Dysbiosis of the Salivary Microbiome is Associated with Hypertension and Correlated with Metabolic Syndrome Biomarkers

Muhammad U Sohail,1 Lars Hedin,2 Maha Al-Asmakh3– 5 1Proteomics Core, Weill Cornell Medicine-Qatar, Doha, Qatar; 2The Royal Norwegian Ministry of Health and Care Services, Molde Kommune, 6413, Norway; 3Department of Biomedical Science, College of Health Sciences, QU Health, Qatar University, Doha, 2...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sohail MU, Hedin L, Al-Asmakh M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	hypertension salivary microbiome qatar biobank lipid profile prevotella veillonella Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/5e168df6dde7469fb71f032dd5526103
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5e168df6dde7469fb71f032dd5526103
record_format	dspace
spelling	oai:doaj.org-article:5e168df6dde7469fb71f032dd55261032021-11-25T18:55:29ZDysbiosis of the Salivary Microbiome is Associated with Hypertension and Correlated with Metabolic Syndrome Biomarkers1178-7007https://doaj.org/article/5e168df6dde7469fb71f032dd55261032021-11-01T00:00:00Zhttps://www.dovepress.com/dysbiosis-of-the-salivary-microbiome-is-associated-with-hypertension-a-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Muhammad U Sohail,1 Lars Hedin,2 Maha Al-Asmakh3– 5 1Proteomics Core, Weill Cornell Medicine-Qatar, Doha, Qatar; 2The Royal Norwegian Ministry of Health and Care Services, Molde Kommune, 6413, Norway; 3Department of Biomedical Science, College of Health Sciences, QU Health, Qatar University, Doha, 2713, Qatar; 4Biomedical Research Center, Qatar University, Doha, 2713, Qatar; 5Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, QatarCorrespondence: Maha Al-Asmakh Tel +974 4403 4789Fax +974-4403-1351Email maha.alasmakh@qu.edu.qaBackground: Hypertension (HT) is an idiopathic disease with severe complications and a high incidence of global mortality. Although the disease shares characteristic features with diabetes and obesity, the complex interplay of endogenous and environmental factors is not well characterized. The oral microbiome has recently been studied to better understand the role of commensal microorganisms in metabolic disorders, including HT, although its role in disease etiology is unclear.Methods: To bridge this gap, we compared the oral microbiome and clinical chemistry of adult subjects enrolled at Qatar Biobank. Clinical chemistry was performed using Roche Cobas-6000 analyzer. Saliva samples were subjected to 16S rRNA sequencing using Illumina MiSeq platform. Cross-gender comparisons were made between control (males/females) (C-M and C-F) and HT (HT-M and HT-F) groups.Results: The HT groups had higher (p ≤ 0.05) BMI, plasma glucose, insulin, C-peptide, and alkaline phosphatase (ALP) concentrations. Triglycerides, cholesterol, LDL-cholesterol, and sodium ions were similar among the groups. The microbiome was predominantly occupied by Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria. Firmicutes were higher (p ≤ 0.05) in the HT groups, whereas Proteobacteria was only higher in the C-F group. Prevotella and Veillonella were significantly higher in the HT groups and exhibited a positive correlation with blood pressure and hyperglycemia. In contrast to other studies, the mathematical summation of priori-select microbes reveals that nitrate-reducing microbes were higher in the HT groups compared with the controls.Conclusion: In conclusion, these observations suggest a strong association of HT with microbial dysbiosis, where microbial species other than nitrate-reducing microbes contribute to blood pressure regulation. The findings affirm plausible microbial signatures of hypertension and suggest manipulating these microbes as a novel treatment modality. Future experiments are warranted for the mechanistic investigation of hypertension metagenomics and microbial activity.Keywords: hypertension, salivary microbiome, Qatar Biobank, lipid profile, Prevotella, VeillonellaSohail MUHedin LAl-Asmakh MDove Medical Pressarticlehypertensionsalivary microbiomeqatar biobanklipid profileprevotellaveillonellaSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 4641-4653 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hypertension salivary microbiome qatar biobank lipid profile prevotella veillonella Specialties of internal medicine RC581-951
spellingShingle	hypertension salivary microbiome qatar biobank lipid profile prevotella veillonella Specialties of internal medicine RC581-951 Sohail MU Hedin L Al-Asmakh M Dysbiosis of the Salivary Microbiome is Associated with Hypertension and Correlated with Metabolic Syndrome Biomarkers
description	Muhammad U Sohail,1 Lars Hedin,2 Maha Al-Asmakh3– 5 1Proteomics Core, Weill Cornell Medicine-Qatar, Doha, Qatar; 2The Royal Norwegian Ministry of Health and Care Services, Molde Kommune, 6413, Norway; 3Department of Biomedical Science, College of Health Sciences, QU Health, Qatar University, Doha, 2713, Qatar; 4Biomedical Research Center, Qatar University, Doha, 2713, Qatar; 5Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, QatarCorrespondence: Maha Al-Asmakh Tel +974 4403 4789Fax +974-4403-1351Email maha.alasmakh@qu.edu.qaBackground: Hypertension (HT) is an idiopathic disease with severe complications and a high incidence of global mortality. Although the disease shares characteristic features with diabetes and obesity, the complex interplay of endogenous and environmental factors is not well characterized. The oral microbiome has recently been studied to better understand the role of commensal microorganisms in metabolic disorders, including HT, although its role in disease etiology is unclear.Methods: To bridge this gap, we compared the oral microbiome and clinical chemistry of adult subjects enrolled at Qatar Biobank. Clinical chemistry was performed using Roche Cobas-6000 analyzer. Saliva samples were subjected to 16S rRNA sequencing using Illumina MiSeq platform. Cross-gender comparisons were made between control (males/females) (C-M and C-F) and HT (HT-M and HT-F) groups.Results: The HT groups had higher (p ≤ 0.05) BMI, plasma glucose, insulin, C-peptide, and alkaline phosphatase (ALP) concentrations. Triglycerides, cholesterol, LDL-cholesterol, and sodium ions were similar among the groups. The microbiome was predominantly occupied by Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria. Firmicutes were higher (p ≤ 0.05) in the HT groups, whereas Proteobacteria was only higher in the C-F group. Prevotella and Veillonella were significantly higher in the HT groups and exhibited a positive correlation with blood pressure and hyperglycemia. In contrast to other studies, the mathematical summation of priori-select microbes reveals that nitrate-reducing microbes were higher in the HT groups compared with the controls.Conclusion: In conclusion, these observations suggest a strong association of HT with microbial dysbiosis, where microbial species other than nitrate-reducing microbes contribute to blood pressure regulation. The findings affirm plausible microbial signatures of hypertension and suggest manipulating these microbes as a novel treatment modality. Future experiments are warranted for the mechanistic investigation of hypertension metagenomics and microbial activity.Keywords: hypertension, salivary microbiome, Qatar Biobank, lipid profile, Prevotella, Veillonella
format	article
author	Sohail MU Hedin L Al-Asmakh M
author_facet	Sohail MU Hedin L Al-Asmakh M
author_sort	Sohail MU
title	Dysbiosis of the Salivary Microbiome is Associated with Hypertension and Correlated with Metabolic Syndrome Biomarkers
title_short	Dysbiosis of the Salivary Microbiome is Associated with Hypertension and Correlated with Metabolic Syndrome Biomarkers
title_full	Dysbiosis of the Salivary Microbiome is Associated with Hypertension and Correlated with Metabolic Syndrome Biomarkers
title_fullStr	Dysbiosis of the Salivary Microbiome is Associated with Hypertension and Correlated with Metabolic Syndrome Biomarkers
title_full_unstemmed	Dysbiosis of the Salivary Microbiome is Associated with Hypertension and Correlated with Metabolic Syndrome Biomarkers
title_sort	dysbiosis of the salivary microbiome is associated with hypertension and correlated with metabolic syndrome biomarkers
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/5e168df6dde7469fb71f032dd5526103
work_keys_str_mv	AT sohailmu dysbiosisofthesalivarymicrobiomeisassociatedwithhypertensionandcorrelatedwithmetabolicsyndromebiomarkers AT hedinl dysbiosisofthesalivarymicrobiomeisassociatedwithhypertensionandcorrelatedwithmetabolicsyndromebiomarkers AT alasmakhm dysbiosisofthesalivarymicrobiomeisassociatedwithhypertensionandcorrelatedwithmetabolicsyndromebiomarkers
_version_	1718410525203759104

Dysbiosis of the Salivary Microbiome is Associated with Hypertension and Correlated with Metabolic Syndrome Biomarkers

Ejemplares similares