Acute kidney injury enhances outcome prediction ability of sequential organ failure assessment score in critically ill patients.

<h4>Introduction</h4>Acute kidney injury (AKI) is a common and serious complication in intensive care unit (ICU) patients and also often part of a multiple organ failure syndrome. The sequential organ failure assessment (SOFA) score is an excellent tool for assessing the extent of organ...

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Autores principales:	Chih-Hsiang Chang, Pei-Chun Fan, Ming-Yang Chang, Ya-Chung Tian, Cheng-Chieh Hung, Ji-Tseng Fang, Chih-Wei Yang, Yung-Chang Chen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5e1736db5f7441cfa3cc58f168088631
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spelling	oai:doaj.org-article:5e1736db5f7441cfa3cc58f1680886312021-11-25T05:58:03ZAcute kidney injury enhances outcome prediction ability of sequential organ failure assessment score in critically ill patients.1932-620310.1371/journal.pone.0109649https://doaj.org/article/5e1736db5f7441cfa3cc58f1680886312014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0109649https://doaj.org/toc/1932-6203<h4>Introduction</h4>Acute kidney injury (AKI) is a common and serious complication in intensive care unit (ICU) patients and also often part of a multiple organ failure syndrome. The sequential organ failure assessment (SOFA) score is an excellent tool for assessing the extent of organ dysfunction in critically ill patients. This study aimed to evaluate the outcome prediction ability of SOFA and Acute Physiology and Chronic Health Evaluation (APACHE) III score in ICU patients with AKI.<h4>Methods</h4>A total of 543 critically ill patients were admitted to the medical ICU of a tertiary-care hospital from July 2007 to June 2008. Demographic, clinical and laboratory variables were prospectively recorded for post hoc analysis as predictors of survival on the first day of ICU admission.<h4>Results</h4>One hundred and eighty-seven (34.4%) patients presented with AKI on the first day of ICU admission based on the risk of renal failure, injury to kidney, failure of kidney function, loss of kidney function, and end-stage renal failure (RIFLE) classification. Major causes of the ICU admissions involved respiratory failure (58%). Overall in-ICU mortality was 37.9% and the hospital mortality was 44.7%. The predictive accuracy for ICU mortality of SOFA (areas under the receiver operating characteristic curves: 0.815±0.032) was as good as APACHE III in the AKI group. However, cumulative survival rates at 6-month follow-up following hospital discharge differed significantly (p<0.001) for SOFA score ≤10 vs. ≥11 in these ICU patients with AKI.<h4>Conclusions</h4>For patients coexisting with AKI admitted to ICU, this work recommends application of SOFA by physicians to assess ICU mortality because of its practicality and low cost. A SOFA score of ≥ "11" on ICU day 1 should be considered an indicator of negative short-term outcome.Chih-Hsiang ChangPei-Chun FanMing-Yang ChangYa-Chung TianCheng-Chieh HungJi-Tseng FangChih-Wei YangYung-Chang ChenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 10, p e109649 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chih-Hsiang Chang Pei-Chun Fan Ming-Yang Chang Ya-Chung Tian Cheng-Chieh Hung Ji-Tseng Fang Chih-Wei Yang Yung-Chang Chen Acute kidney injury enhances outcome prediction ability of sequential organ failure assessment score in critically ill patients.
description	<h4>Introduction</h4>Acute kidney injury (AKI) is a common and serious complication in intensive care unit (ICU) patients and also often part of a multiple organ failure syndrome. The sequential organ failure assessment (SOFA) score is an excellent tool for assessing the extent of organ dysfunction in critically ill patients. This study aimed to evaluate the outcome prediction ability of SOFA and Acute Physiology and Chronic Health Evaluation (APACHE) III score in ICU patients with AKI.<h4>Methods</h4>A total of 543 critically ill patients were admitted to the medical ICU of a tertiary-care hospital from July 2007 to June 2008. Demographic, clinical and laboratory variables were prospectively recorded for post hoc analysis as predictors of survival on the first day of ICU admission.<h4>Results</h4>One hundred and eighty-seven (34.4%) patients presented with AKI on the first day of ICU admission based on the risk of renal failure, injury to kidney, failure of kidney function, loss of kidney function, and end-stage renal failure (RIFLE) classification. Major causes of the ICU admissions involved respiratory failure (58%). Overall in-ICU mortality was 37.9% and the hospital mortality was 44.7%. The predictive accuracy for ICU mortality of SOFA (areas under the receiver operating characteristic curves: 0.815±0.032) was as good as APACHE III in the AKI group. However, cumulative survival rates at 6-month follow-up following hospital discharge differed significantly (p<0.001) for SOFA score ≤10 vs. ≥11 in these ICU patients with AKI.<h4>Conclusions</h4>For patients coexisting with AKI admitted to ICU, this work recommends application of SOFA by physicians to assess ICU mortality because of its practicality and low cost. A SOFA score of ≥ "11" on ICU day 1 should be considered an indicator of negative short-term outcome.
format	article
author	Chih-Hsiang Chang Pei-Chun Fan Ming-Yang Chang Ya-Chung Tian Cheng-Chieh Hung Ji-Tseng Fang Chih-Wei Yang Yung-Chang Chen
author_facet	Chih-Hsiang Chang Pei-Chun Fan Ming-Yang Chang Ya-Chung Tian Cheng-Chieh Hung Ji-Tseng Fang Chih-Wei Yang Yung-Chang Chen
author_sort	Chih-Hsiang Chang
title	Acute kidney injury enhances outcome prediction ability of sequential organ failure assessment score in critically ill patients.
title_short	Acute kidney injury enhances outcome prediction ability of sequential organ failure assessment score in critically ill patients.
title_full	Acute kidney injury enhances outcome prediction ability of sequential organ failure assessment score in critically ill patients.
title_fullStr	Acute kidney injury enhances outcome prediction ability of sequential organ failure assessment score in critically ill patients.
title_full_unstemmed	Acute kidney injury enhances outcome prediction ability of sequential organ failure assessment score in critically ill patients.
title_sort	acute kidney injury enhances outcome prediction ability of sequential organ failure assessment score in critically ill patients.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/5e1736db5f7441cfa3cc58f168088631
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Acute kidney injury enhances outcome prediction ability of sequential organ failure assessment score in critically ill patients.

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