Remodeling of monoplanar Purkinje cell dendrites during cerebellar circuit formation.

Dendrite arborization patterns are critical determinants of neuronal connectivity and integration. Planar and highly branched dendrites of the cerebellar Purkinje cell receive specific topographical projections from two major afferent pathways; a single climbing fiber axon from the inferior olive th...

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Autores principales:	Megumi Kaneko, Kazuhiko Yamaguchi, Mototsugu Eiraku, Motohiko Sato, Norio Takata, Yoshimoto Kiyohara, Masayoshi Mishina, Hajime Hirase, Tsutomu Hashikawa, Mineko Kengaku
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5e194df6f02c4795b56c97a220fbe38f
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spelling	oai:doaj.org-article:5e194df6f02c4795b56c97a220fbe38f2021-11-18T06:52:49ZRemodeling of monoplanar Purkinje cell dendrites during cerebellar circuit formation.1932-620310.1371/journal.pone.0020108https://doaj.org/article/5e194df6f02c4795b56c97a220fbe38f2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21655286/?tool=EBIhttps://doaj.org/toc/1932-6203Dendrite arborization patterns are critical determinants of neuronal connectivity and integration. Planar and highly branched dendrites of the cerebellar Purkinje cell receive specific topographical projections from two major afferent pathways; a single climbing fiber axon from the inferior olive that extend along Purkinje dendrites, and parallel fiber axons of granule cells that contact vertically to the plane of dendrites. It has been believed that murine Purkinje cell dendrites extend in a single parasagittal plane in the molecular layer after the cell polarity is determined during the early postnatal development. By three-dimensional confocal analysis of growing Purkinje cells, we observed that mouse Purkinje cells underwent dynamic dendritic remodeling during circuit maturation in the third postnatal week. After dendrites were polarized and flattened in the early second postnatal week, dendritic arbors gradually expanded in multiple sagittal planes in the molecular layer by intensive growth and branching by the third postnatal week. Dendrites then became confined to a single plane in the fourth postnatal week. Multiplanar Purkinje cells in the third week were often associated by ectopic climbing fibers innervating nearby Purkinje cells in distinct sagittal planes. The mature monoplanar arborization was disrupted in mutant mice with abnormal Purkinje cell connectivity and motor discoordination. The dendrite remodeling was also impaired by pharmacological disruption of normal afferent activity during the second or third postnatal week. Our results suggest that the monoplanar arborization of Purkinje cells is coupled with functional development of the cerebellar circuitry.Megumi KanekoKazuhiko YamaguchiMototsugu EirakuMotohiko SatoNorio TakataYoshimoto KiyoharaMasayoshi MishinaHajime HiraseTsutomu HashikawaMineko KengakuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 5, p e20108 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Megumi Kaneko Kazuhiko Yamaguchi Mototsugu Eiraku Motohiko Sato Norio Takata Yoshimoto Kiyohara Masayoshi Mishina Hajime Hirase Tsutomu Hashikawa Mineko Kengaku Remodeling of monoplanar Purkinje cell dendrites during cerebellar circuit formation.
description	Dendrite arborization patterns are critical determinants of neuronal connectivity and integration. Planar and highly branched dendrites of the cerebellar Purkinje cell receive specific topographical projections from two major afferent pathways; a single climbing fiber axon from the inferior olive that extend along Purkinje dendrites, and parallel fiber axons of granule cells that contact vertically to the plane of dendrites. It has been believed that murine Purkinje cell dendrites extend in a single parasagittal plane in the molecular layer after the cell polarity is determined during the early postnatal development. By three-dimensional confocal analysis of growing Purkinje cells, we observed that mouse Purkinje cells underwent dynamic dendritic remodeling during circuit maturation in the third postnatal week. After dendrites were polarized and flattened in the early second postnatal week, dendritic arbors gradually expanded in multiple sagittal planes in the molecular layer by intensive growth and branching by the third postnatal week. Dendrites then became confined to a single plane in the fourth postnatal week. Multiplanar Purkinje cells in the third week were often associated by ectopic climbing fibers innervating nearby Purkinje cells in distinct sagittal planes. The mature monoplanar arborization was disrupted in mutant mice with abnormal Purkinje cell connectivity and motor discoordination. The dendrite remodeling was also impaired by pharmacological disruption of normal afferent activity during the second or third postnatal week. Our results suggest that the monoplanar arborization of Purkinje cells is coupled with functional development of the cerebellar circuitry.
format	article
author	Megumi Kaneko Kazuhiko Yamaguchi Mototsugu Eiraku Motohiko Sato Norio Takata Yoshimoto Kiyohara Masayoshi Mishina Hajime Hirase Tsutomu Hashikawa Mineko Kengaku
author_facet	Megumi Kaneko Kazuhiko Yamaguchi Mototsugu Eiraku Motohiko Sato Norio Takata Yoshimoto Kiyohara Masayoshi Mishina Hajime Hirase Tsutomu Hashikawa Mineko Kengaku
author_sort	Megumi Kaneko
title	Remodeling of monoplanar Purkinje cell dendrites during cerebellar circuit formation.
title_short	Remodeling of monoplanar Purkinje cell dendrites during cerebellar circuit formation.
title_full	Remodeling of monoplanar Purkinje cell dendrites during cerebellar circuit formation.
title_fullStr	Remodeling of monoplanar Purkinje cell dendrites during cerebellar circuit formation.
title_full_unstemmed	Remodeling of monoplanar Purkinje cell dendrites during cerebellar circuit formation.
title_sort	remodeling of monoplanar purkinje cell dendrites during cerebellar circuit formation.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/5e194df6f02c4795b56c97a220fbe38f
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_version_	1718424231744634880

Remodeling of monoplanar Purkinje cell dendrites during cerebellar circuit formation.

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