Relationship between neural crest cells and cranial mesoderm during head muscle development.

<h4>Background</h4>In vertebrates, the skeletal elements of the jaw, together with the connective tissues and tendons, originate from neural crest cells, while the associated muscles derive mainly from cranial mesoderm. Previous studies have shown that neural crest cells migrate in close...

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Autores principales:	Julien Grenier, Marie-Aimée Teillet, Raphaëlle Grifone, Robert G Kelly, Delphine Duprez
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5e1cad1f4c2042ea9d492aa92dbcd3ac
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spelling	oai:doaj.org-article:5e1cad1f4c2042ea9d492aa92dbcd3ac2021-11-25T06:17:26ZRelationship between neural crest cells and cranial mesoderm during head muscle development.1932-620310.1371/journal.pone.0004381https://doaj.org/article/5e1cad1f4c2042ea9d492aa92dbcd3ac2009-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19198652/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>In vertebrates, the skeletal elements of the jaw, together with the connective tissues and tendons, originate from neural crest cells, while the associated muscles derive mainly from cranial mesoderm. Previous studies have shown that neural crest cells migrate in close association with cranial mesoderm and then circumscribe but do not penetrate the core of muscle precursor cells of the branchial arches at early stages of development, thus defining a sharp boundary between neural crest cells and mesodermal muscle progenitor cells. Tendons constitute one of the neural crest derivatives likely to interact with muscle formation. However, head tendon formation has not been studied, nor have tendon and muscle interactions in the head.<h4>Methodology/principal findings</h4>Reinvestigation of the relationship between cranial neural crest cells and muscle precursor cells during development of the first branchial arch, using quail/chick chimeras and molecular markers revealed several novel features concerning the interface between neural crest cells and mesoderm. We observed that neural crest cells migrate into the cephalic mesoderm containing myogenic precursor cells, leading to the presence of neural crest cells inside the mesodermal core of the first branchial arch. We have also established that all the forming tendons associated with branchiomeric and eye muscles are of neural crest origin and express the Scleraxis marker in chick and mouse embryos. Moreover, analysis of Scleraxis expression in the absence of branchiomeric muscles in Tbx1(-/-) mutant mice, showed that muscles are not necessary for the initiation of tendon formation but are required for further tendon development.<h4>Conclusions/significance</h4>This results show that neural crest cells and muscle progenitor cells are more extensively mixed than previously believed during arch development. In addition, our results show that interactions between muscles and tendons during craniofacial development are similar to those observed in the limb, despite the distinct embryological origin of these cell types in the head.Julien GrenierMarie-Aimée TeilletRaphaëlle GrifoneRobert G KellyDelphine DuprezPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 2, p e4381 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julien Grenier Marie-Aimée Teillet Raphaëlle Grifone Robert G Kelly Delphine Duprez Relationship between neural crest cells and cranial mesoderm during head muscle development.
description	<h4>Background</h4>In vertebrates, the skeletal elements of the jaw, together with the connective tissues and tendons, originate from neural crest cells, while the associated muscles derive mainly from cranial mesoderm. Previous studies have shown that neural crest cells migrate in close association with cranial mesoderm and then circumscribe but do not penetrate the core of muscle precursor cells of the branchial arches at early stages of development, thus defining a sharp boundary between neural crest cells and mesodermal muscle progenitor cells. Tendons constitute one of the neural crest derivatives likely to interact with muscle formation. However, head tendon formation has not been studied, nor have tendon and muscle interactions in the head.<h4>Methodology/principal findings</h4>Reinvestigation of the relationship between cranial neural crest cells and muscle precursor cells during development of the first branchial arch, using quail/chick chimeras and molecular markers revealed several novel features concerning the interface between neural crest cells and mesoderm. We observed that neural crest cells migrate into the cephalic mesoderm containing myogenic precursor cells, leading to the presence of neural crest cells inside the mesodermal core of the first branchial arch. We have also established that all the forming tendons associated with branchiomeric and eye muscles are of neural crest origin and express the Scleraxis marker in chick and mouse embryos. Moreover, analysis of Scleraxis expression in the absence of branchiomeric muscles in Tbx1(-/-) mutant mice, showed that muscles are not necessary for the initiation of tendon formation but are required for further tendon development.<h4>Conclusions/significance</h4>This results show that neural crest cells and muscle progenitor cells are more extensively mixed than previously believed during arch development. In addition, our results show that interactions between muscles and tendons during craniofacial development are similar to those observed in the limb, despite the distinct embryological origin of these cell types in the head.
format	article
author	Julien Grenier Marie-Aimée Teillet Raphaëlle Grifone Robert G Kelly Delphine Duprez
author_facet	Julien Grenier Marie-Aimée Teillet Raphaëlle Grifone Robert G Kelly Delphine Duprez
author_sort	Julien Grenier
title	Relationship between neural crest cells and cranial mesoderm during head muscle development.
title_short	Relationship between neural crest cells and cranial mesoderm during head muscle development.
title_full	Relationship between neural crest cells and cranial mesoderm during head muscle development.
title_fullStr	Relationship between neural crest cells and cranial mesoderm during head muscle development.
title_full_unstemmed	Relationship between neural crest cells and cranial mesoderm during head muscle development.
title_sort	relationship between neural crest cells and cranial mesoderm during head muscle development.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/5e1cad1f4c2042ea9d492aa92dbcd3ac
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_version_	1718413985603125248

Relationship between neural crest cells and cranial mesoderm during head muscle development.

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