Changes in Treatment Patterns and Globe Salvage Rate of Advanced Retinoblastoma in Korea: Efficacy of Intra-Arterial Chemotherapy

(1) Background: To analyze changes in treatment patterns for advanced retinoblastoma over time and differences in globe salvage rates; (2) Methods: Retrospective, observational case-control study of 97 eyes of 91 patients with advanced retinoblastoma (Group D and E).; (3) Results: Patients were divi...

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Autores principales:	Dong Hyun Lee, Jung Woo Han, Seung Min Hahn, Byung Moon Kim, Chuhl Joo Lyu, Sung Chul Lee, Dong Joon Kim, Christopher Seungkyu Lee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	retinoblastoma antineoplastic agents intra-arterial chemotherapy intravenous chemotherapy intravitreal chemotherapy Medicine R
Acceso en línea:	https://doaj.org/article/5e20bdd3ac54417cbd4507018f17f7a1
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spelling	oai:doaj.org-article:5e20bdd3ac54417cbd4507018f17f7a12021-11-25T18:02:38ZChanges in Treatment Patterns and Globe Salvage Rate of Advanced Retinoblastoma in Korea: Efficacy of Intra-Arterial Chemotherapy10.3390/jcm102254212077-0383https://doaj.org/article/5e20bdd3ac54417cbd4507018f17f7a12021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5421https://doaj.org/toc/2077-0383(1) Background: To analyze changes in treatment patterns for advanced retinoblastoma over time and differences in globe salvage rates; (2) Methods: Retrospective, observational case-control study of 97 eyes of 91 patients with advanced retinoblastoma (Group D and E).; (3) Results: Patients were divided into two groups based on whether they were treated before or after intraarterial chemotherapy (IAC) was introduced in our center in 2010. Before 2010, primary treatment pattern was enucleation, which was performed in 57.6% of cases, whereas primary treatment pattern after 2010 was IAC combined with intravenous chemotherapy (IVC), which was performed in 78.1%. Intravitreal chemotherapy (IVitC) has been performed to treat vitreous and subretinal seeding since 2015. The 5-year globe salvage rate of IVC alone was 24.0% for Group D and 0% for Group E, whereas that of IVC–IAC was 50.4% for Group D and 49.7% for Group E. Whether IVitC was performed or not did not significantly contribute to globe salvage rate. There was one metastatic death in the IVC alone group.; (4) Conclusions: Primary treatment pattern changed from enucleation to IAC-based treatment, which can now save nearly half of eyes with advanced retinoblastoma with excellent safety profile and survival rate.Dong Hyun LeeJung Woo HanSeung Min HahnByung Moon KimChuhl Joo LyuSung Chul LeeDong Joon KimChristopher Seungkyu LeeMDPI AGarticleretinoblastomaantineoplastic agentsintra-arterial chemotherapyintravenous chemotherapyintravitreal chemotherapyMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5421, p 5421 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	retinoblastoma antineoplastic agents intra-arterial chemotherapy intravenous chemotherapy intravitreal chemotherapy Medicine R
spellingShingle	retinoblastoma antineoplastic agents intra-arterial chemotherapy intravenous chemotherapy intravitreal chemotherapy Medicine R Dong Hyun Lee Jung Woo Han Seung Min Hahn Byung Moon Kim Chuhl Joo Lyu Sung Chul Lee Dong Joon Kim Christopher Seungkyu Lee Changes in Treatment Patterns and Globe Salvage Rate of Advanced Retinoblastoma in Korea: Efficacy of Intra-Arterial Chemotherapy
description	(1) Background: To analyze changes in treatment patterns for advanced retinoblastoma over time and differences in globe salvage rates; (2) Methods: Retrospective, observational case-control study of 97 eyes of 91 patients with advanced retinoblastoma (Group D and E).; (3) Results: Patients were divided into two groups based on whether they were treated before or after intraarterial chemotherapy (IAC) was introduced in our center in 2010. Before 2010, primary treatment pattern was enucleation, which was performed in 57.6% of cases, whereas primary treatment pattern after 2010 was IAC combined with intravenous chemotherapy (IVC), which was performed in 78.1%. Intravitreal chemotherapy (IVitC) has been performed to treat vitreous and subretinal seeding since 2015. The 5-year globe salvage rate of IVC alone was 24.0% for Group D and 0% for Group E, whereas that of IVC–IAC was 50.4% for Group D and 49.7% for Group E. Whether IVitC was performed or not did not significantly contribute to globe salvage rate. There was one metastatic death in the IVC alone group.; (4) Conclusions: Primary treatment pattern changed from enucleation to IAC-based treatment, which can now save nearly half of eyes with advanced retinoblastoma with excellent safety profile and survival rate.
format	article
author	Dong Hyun Lee Jung Woo Han Seung Min Hahn Byung Moon Kim Chuhl Joo Lyu Sung Chul Lee Dong Joon Kim Christopher Seungkyu Lee
author_facet	Dong Hyun Lee Jung Woo Han Seung Min Hahn Byung Moon Kim Chuhl Joo Lyu Sung Chul Lee Dong Joon Kim Christopher Seungkyu Lee
author_sort	Dong Hyun Lee
title	Changes in Treatment Patterns and Globe Salvage Rate of Advanced Retinoblastoma in Korea: Efficacy of Intra-Arterial Chemotherapy
title_short	Changes in Treatment Patterns and Globe Salvage Rate of Advanced Retinoblastoma in Korea: Efficacy of Intra-Arterial Chemotherapy
title_full	Changes in Treatment Patterns and Globe Salvage Rate of Advanced Retinoblastoma in Korea: Efficacy of Intra-Arterial Chemotherapy
title_fullStr	Changes in Treatment Patterns and Globe Salvage Rate of Advanced Retinoblastoma in Korea: Efficacy of Intra-Arterial Chemotherapy
title_full_unstemmed	Changes in Treatment Patterns and Globe Salvage Rate of Advanced Retinoblastoma in Korea: Efficacy of Intra-Arterial Chemotherapy
title_sort	changes in treatment patterns and globe salvage rate of advanced retinoblastoma in korea: efficacy of intra-arterial chemotherapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5e20bdd3ac54417cbd4507018f17f7a1
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Changes in Treatment Patterns and Globe Salvage Rate of Advanced Retinoblastoma in Korea: Efficacy of Intra-Arterial Chemotherapy

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