MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels

Insulin receptor levels at the cell surface are reduced in insulin resistance, for reasons that are not fully understood. Here, the authors identify the E3 ubiquitin ligase MARCH1 as a direct regulator of basal insulin receptor surface levels and, therefore, insulin signalling.

Guardado en:

Detalles Bibliográficos
Autores principales:	Arvindhan Nagarajan, Max C. Petersen, Ali R. Nasiri, Gina Butrico, Annie Fung, Hai-Bin Ruan, Romy Kursawe, Sonia Caprio, Jacques Thibodeau, Marie-Claude Bourgeois-Daigneault, Lisha Sun, Guangping Gao, Sanjay Bhanot, Michael J. Jurczak, Michael R. Green, Gerald I. Shulman, Narendra Wajapeyee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5e20ff02ef4b4bf79837c323cd66c1bb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5e20ff02ef4b4bf79837c323cd66c1bb
record_format	dspace
spelling	oai:doaj.org-article:5e20ff02ef4b4bf79837c323cd66c1bb2021-12-02T16:50:15ZMARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels10.1038/ncomms126392041-1723https://doaj.org/article/5e20ff02ef4b4bf79837c323cd66c1bb2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12639https://doaj.org/toc/2041-1723Insulin receptor levels at the cell surface are reduced in insulin resistance, for reasons that are not fully understood. Here, the authors identify the E3 ubiquitin ligase MARCH1 as a direct regulator of basal insulin receptor surface levels and, therefore, insulin signalling.Arvindhan NagarajanMax C. PetersenAli R. NasiriGina ButricoAnnie FungHai-Bin RuanRomy KursaweSonia CaprioJacques ThibodeauMarie-Claude Bourgeois-DaigneaultLisha SunGuangping GaoSanjay BhanotMichael J. JurczakMichael R. GreenGerald I. ShulmanNarendra WajapeyeeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Arvindhan Nagarajan Max C. Petersen Ali R. Nasiri Gina Butrico Annie Fung Hai-Bin Ruan Romy Kursawe Sonia Caprio Jacques Thibodeau Marie-Claude Bourgeois-Daigneault Lisha Sun Guangping Gao Sanjay Bhanot Michael J. Jurczak Michael R. Green Gerald I. Shulman Narendra Wajapeyee MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels
description	Insulin receptor levels at the cell surface are reduced in insulin resistance, for reasons that are not fully understood. Here, the authors identify the E3 ubiquitin ligase MARCH1 as a direct regulator of basal insulin receptor surface levels and, therefore, insulin signalling.
format	article
author	Arvindhan Nagarajan Max C. Petersen Ali R. Nasiri Gina Butrico Annie Fung Hai-Bin Ruan Romy Kursawe Sonia Caprio Jacques Thibodeau Marie-Claude Bourgeois-Daigneault Lisha Sun Guangping Gao Sanjay Bhanot Michael J. Jurczak Michael R. Green Gerald I. Shulman Narendra Wajapeyee
author_facet	Arvindhan Nagarajan Max C. Petersen Ali R. Nasiri Gina Butrico Annie Fung Hai-Bin Ruan Romy Kursawe Sonia Caprio Jacques Thibodeau Marie-Claude Bourgeois-Daigneault Lisha Sun Guangping Gao Sanjay Bhanot Michael J. Jurczak Michael R. Green Gerald I. Shulman Narendra Wajapeyee
author_sort	Arvindhan Nagarajan
title	MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels
title_short	MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels
title_full	MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels
title_fullStr	MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels
title_full_unstemmed	MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels
title_sort	march1 regulates insulin sensitivity by controlling cell surface insulin receptor levels
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/5e20ff02ef4b4bf79837c323cd66c1bb
work_keys_str_mv	AT arvindhannagarajan march1regulatesinsulinsensitivitybycontrollingcellsurfaceinsulinreceptorlevels AT maxcpetersen march1regulatesinsulinsensitivitybycontrollingcellsurfaceinsulinreceptorlevels AT alirnasiri march1regulatesinsulinsensitivitybycontrollingcellsurfaceinsulinreceptorlevels AT ginabutrico march1regulatesinsulinsensitivitybycontrollingcellsurfaceinsulinreceptorlevels AT anniefung march1regulatesinsulinsensitivitybycontrollingcellsurfaceinsulinreceptorlevels AT haibinruan march1regulatesinsulinsensitivitybycontrollingcellsurfaceinsulinreceptorlevels AT romykursawe march1regulatesinsulinsensitivitybycontrollingcellsurfaceinsulinreceptorlevels AT soniacaprio march1regulatesinsulinsensitivitybycontrollingcellsurfaceinsulinreceptorlevels AT jacquesthibodeau march1regulatesinsulinsensitivitybycontrollingcellsurfaceinsulinreceptorlevels AT marieclaudebourgeoisdaigneault march1regulatesinsulinsensitivitybycontrollingcellsurfaceinsulinreceptorlevels AT lishasun march1regulatesinsulinsensitivitybycontrollingcellsurfaceinsulinreceptorlevels AT guangpinggao march1regulatesinsulinsensitivitybycontrollingcellsurfaceinsulinreceptorlevels AT sanjaybhanot march1regulatesinsulinsensitivitybycontrollingcellsurfaceinsulinreceptorlevels AT michaeljjurczak march1regulatesinsulinsensitivitybycontrollingcellsurfaceinsulinreceptorlevels AT michaelrgreen march1regulatesinsulinsensitivitybycontrollingcellsurfaceinsulinreceptorlevels AT geraldishulman march1regulatesinsulinsensitivitybycontrollingcellsurfaceinsulinreceptorlevels AT narendrawajapeyee march1regulatesinsulinsensitivitybycontrollingcellsurfaceinsulinreceptorlevels
_version_	1718383039227101184

MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels

Ejemplares similares