A review on nanosystems as an effective approach against infections of Staphylococcus aureus

Kaixiang Zhou,1 Chao Li,1 Dongmei Chen,2 Yuanhu Pan,1 Yanfei Tao,2 Wei Qu,2 Zhenli Liu,2 Xiaofang Wang,3 Shuyu Xie1 1MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei, China; 2National Reference Laboratory of V...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhou KX, Li C, Chen DM, Pan YH, Tao YF, Qu W, Liu ZL, Wang XF, Xie SY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Staphylococcus aureus Infection mechanism Resistance Antibiotics Nanoparticles Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5e228f7edf554c1ca8e230713f60106c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5e228f7edf554c1ca8e230713f60106c
record_format	dspace
spelling	oai:doaj.org-article:5e228f7edf554c1ca8e230713f60106c2021-12-02T02:57:20ZA review on nanosystems as an effective approach against infections of Staphylococcus aureus1178-2013https://doaj.org/article/5e228f7edf554c1ca8e230713f60106c2018-11-01T00:00:00Zhttps://www.dovepress.com/a-review-on-nanosystems-as-an-effective-approach-against-infections-of-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Kaixiang Zhou,1 Chao Li,1 Dongmei Chen,2 Yuanhu Pan,1 Yanfei Tao,2 Wei Qu,2 Zhenli Liu,2 Xiaofang Wang,3 Shuyu Xie1 1MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei, China; 2National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan, Hubei, China; 3Animal Husbandry and Veterinary Institute of Hebei Province, Baoding, Hebei, China Abstract: Staphylococcus aureus (S. aureus) is an important zoonotic bacteria and hazardous for the health of human beings and livestock globally. The characteristics like biofilm forming, facultative intracellular survival, and growing resistance of S. aureus pose a great challenge to its use in therapy. Nanoparticles are considered as a promising way to overcome the infections’ therapeutic problems caused by S. aureus. In this paper, the present progress and challenges of nanoparticles in the treatment of S. aureus infection are focused on stepwise. First, the survival and infection mechanism of S. aureus are analyzed. Second, the treatment challenges posed by S. aureus are provided, which is followed by the third step including the advantages of nanoparticles in improving the penetration and accumulation ability of their payload antibiotics into cell, inhibiting S. aureus biofilm formation, and enhancing the antibacterial activity against resistant isolates. Finally, the challenges and future perspective of nanoparticles for S. aureus infection therapy are introduced. This review will help the readers to realize that the nanosystems can effectively fight against the S. aureus infection by inhibiting biofilm formation, enhancing intracellular delivery, and improving activity against methicillin-resistant S. aureus and small colony variant phenotypes as well as aim to help researchers looking for more efficient nanosystems to combat the S. aureus infections. Keywords: Staphylococcus aureus, infection mechanism, resistance, antibiotics, nanoparticlesZhou KXLi CChen DMPan YHTao YFQu WLiu ZLWang XFXie SYDove Medical PressarticleStaphylococcus aureusInfection mechanismResistanceAntibioticsNanoparticlesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 7333-7347 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Staphylococcus aureus Infection mechanism Resistance Antibiotics Nanoparticles Medicine (General) R5-920
spellingShingle	Staphylococcus aureus Infection mechanism Resistance Antibiotics Nanoparticles Medicine (General) R5-920 Zhou KX Li C Chen DM Pan YH Tao YF Qu W Liu ZL Wang XF Xie SY A review on nanosystems as an effective approach against infections of Staphylococcus aureus
description	Kaixiang Zhou,1 Chao Li,1 Dongmei Chen,2 Yuanhu Pan,1 Yanfei Tao,2 Wei Qu,2 Zhenli Liu,2 Xiaofang Wang,3 Shuyu Xie1 1MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei, China; 2National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan, Hubei, China; 3Animal Husbandry and Veterinary Institute of Hebei Province, Baoding, Hebei, China Abstract: Staphylococcus aureus (S. aureus) is an important zoonotic bacteria and hazardous for the health of human beings and livestock globally. The characteristics like biofilm forming, facultative intracellular survival, and growing resistance of S. aureus pose a great challenge to its use in therapy. Nanoparticles are considered as a promising way to overcome the infections’ therapeutic problems caused by S. aureus. In this paper, the present progress and challenges of nanoparticles in the treatment of S. aureus infection are focused on stepwise. First, the survival and infection mechanism of S. aureus are analyzed. Second, the treatment challenges posed by S. aureus are provided, which is followed by the third step including the advantages of nanoparticles in improving the penetration and accumulation ability of their payload antibiotics into cell, inhibiting S. aureus biofilm formation, and enhancing the antibacterial activity against resistant isolates. Finally, the challenges and future perspective of nanoparticles for S. aureus infection therapy are introduced. This review will help the readers to realize that the nanosystems can effectively fight against the S. aureus infection by inhibiting biofilm formation, enhancing intracellular delivery, and improving activity against methicillin-resistant S. aureus and small colony variant phenotypes as well as aim to help researchers looking for more efficient nanosystems to combat the S. aureus infections. Keywords: Staphylococcus aureus, infection mechanism, resistance, antibiotics, nanoparticles
format	article
author	Zhou KX Li C Chen DM Pan YH Tao YF Qu W Liu ZL Wang XF Xie SY
author_facet	Zhou KX Li C Chen DM Pan YH Tao YF Qu W Liu ZL Wang XF Xie SY
author_sort	Zhou KX
title	A review on nanosystems as an effective approach against infections of Staphylococcus aureus
title_short	A review on nanosystems as an effective approach against infections of Staphylococcus aureus
title_full	A review on nanosystems as an effective approach against infections of Staphylococcus aureus
title_fullStr	A review on nanosystems as an effective approach against infections of Staphylococcus aureus
title_full_unstemmed	A review on nanosystems as an effective approach against infections of Staphylococcus aureus
title_sort	review on nanosystems as an effective approach against infections of staphylococcus aureus
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/5e228f7edf554c1ca8e230713f60106c
work_keys_str_mv	AT zhoukx areviewonnanosystemsasaneffectiveapproachagainstinfectionsofstaphylococcusaureus AT lic areviewonnanosystemsasaneffectiveapproachagainstinfectionsofstaphylococcusaureus AT chendm areviewonnanosystemsasaneffectiveapproachagainstinfectionsofstaphylococcusaureus AT panyh areviewonnanosystemsasaneffectiveapproachagainstinfectionsofstaphylococcusaureus AT taoyf areviewonnanosystemsasaneffectiveapproachagainstinfectionsofstaphylococcusaureus AT quw areviewonnanosystemsasaneffectiveapproachagainstinfectionsofstaphylococcusaureus AT liuzl areviewonnanosystemsasaneffectiveapproachagainstinfectionsofstaphylococcusaureus AT wangxf areviewonnanosystemsasaneffectiveapproachagainstinfectionsofstaphylococcusaureus AT xiesy areviewonnanosystemsasaneffectiveapproachagainstinfectionsofstaphylococcusaureus AT zhoukx reviewonnanosystemsasaneffectiveapproachagainstinfectionsofstaphylococcusaureus AT lic reviewonnanosystemsasaneffectiveapproachagainstinfectionsofstaphylococcusaureus AT chendm reviewonnanosystemsasaneffectiveapproachagainstinfectionsofstaphylococcusaureus AT panyh reviewonnanosystemsasaneffectiveapproachagainstinfectionsofstaphylococcusaureus AT taoyf reviewonnanosystemsasaneffectiveapproachagainstinfectionsofstaphylococcusaureus AT quw reviewonnanosystemsasaneffectiveapproachagainstinfectionsofstaphylococcusaureus AT liuzl reviewonnanosystemsasaneffectiveapproachagainstinfectionsofstaphylococcusaureus AT wangxf reviewonnanosystemsasaneffectiveapproachagainstinfectionsofstaphylococcusaureus AT xiesy reviewonnanosystemsasaneffectiveapproachagainstinfectionsofstaphylococcusaureus
_version_	1718402043124645888

A review on nanosystems as an effective approach against infections of Staphylococcus aureus

Ejemplares similares