Reliable identification of protein-protein interactions by crosslinking mass spectrometry

Cross-linking mass spectrometry (MS) can identify protein-protein interaction (PPI) networks but assessing the reliability of these data remains challenging. To address this issue, the authors develop and validate a method to determine the false-discovery rate of PPIs identified by cross-linking MS.

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Autores principales:	Swantje Lenz, Ludwig R. Sinn, Francis J. O’Reilly, Lutz Fischer, Fritz Wegner, Juri Rappsilber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5e27def07ee34f139b97a8e8b802239b
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spelling	oai:doaj.org-article:5e27def07ee34f139b97a8e8b802239b2021-12-02T18:06:34ZReliable identification of protein-protein interactions by crosslinking mass spectrometry10.1038/s41467-021-23666-z2041-1723https://doaj.org/article/5e27def07ee34f139b97a8e8b802239b2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23666-zhttps://doaj.org/toc/2041-1723Cross-linking mass spectrometry (MS) can identify protein-protein interaction (PPI) networks but assessing the reliability of these data remains challenging. To address this issue, the authors develop and validate a method to determine the false-discovery rate of PPIs identified by cross-linking MS.Swantje LenzLudwig R. SinnFrancis J. O’ReillyLutz FischerFritz WegnerJuri RappsilberNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Swantje Lenz Ludwig R. Sinn Francis J. O’Reilly Lutz Fischer Fritz Wegner Juri Rappsilber Reliable identification of protein-protein interactions by crosslinking mass spectrometry
description	Cross-linking mass spectrometry (MS) can identify protein-protein interaction (PPI) networks but assessing the reliability of these data remains challenging. To address this issue, the authors develop and validate a method to determine the false-discovery rate of PPIs identified by cross-linking MS.
format	article
author	Swantje Lenz Ludwig R. Sinn Francis J. O’Reilly Lutz Fischer Fritz Wegner Juri Rappsilber
author_facet	Swantje Lenz Ludwig R. Sinn Francis J. O’Reilly Lutz Fischer Fritz Wegner Juri Rappsilber
author_sort	Swantje Lenz
title	Reliable identification of protein-protein interactions by crosslinking mass spectrometry
title_short	Reliable identification of protein-protein interactions by crosslinking mass spectrometry
title_full	Reliable identification of protein-protein interactions by crosslinking mass spectrometry
title_fullStr	Reliable identification of protein-protein interactions by crosslinking mass spectrometry
title_full_unstemmed	Reliable identification of protein-protein interactions by crosslinking mass spectrometry
title_sort	reliable identification of protein-protein interactions by crosslinking mass spectrometry
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5e27def07ee34f139b97a8e8b802239b
work_keys_str_mv	AT swantjelenz reliableidentificationofproteinproteininteractionsbycrosslinkingmassspectrometry AT ludwigrsinn reliableidentificationofproteinproteininteractionsbycrosslinkingmassspectrometry AT francisjoreilly reliableidentificationofproteinproteininteractionsbycrosslinkingmassspectrometry AT lutzfischer reliableidentificationofproteinproteininteractionsbycrosslinkingmassspectrometry AT fritzwegner reliableidentificationofproteinproteininteractionsbycrosslinkingmassspectrometry AT jurirappsilber reliableidentificationofproteinproteininteractionsbycrosslinkingmassspectrometry
_version_	1718378630789201920

Reliable identification of protein-protein interactions by crosslinking mass spectrometry

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