Reliable identification of protein-protein interactions by crosslinking mass spectrometry

Cross-linking mass spectrometry (MS) can identify protein-protein interaction (PPI) networks but assessing the reliability of these data remains challenging. To address this issue, the authors develop and validate a method to determine the false-discovery rate of PPIs identified by cross-linking MS.

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Autores principales: Swantje Lenz, Ludwig R. Sinn, Francis J. O’Reilly, Lutz Fischer, Fritz Wegner, Juri Rappsilber
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/5e27def07ee34f139b97a8e8b802239b
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