EFFECTS OF DIFFERENT ADJUVANTS UPON IMMUNOGENICITY OF ANTI-GROUP B STREPTOCOCCAL VACCINE COMPONENTS

Abstract. Design of an effective and safe vaccine against pathogenic streptococci is still on the agenda, in spite of numerous attempts in this area undertaken by different laboratories. In order to improve immunogenicity of recombinant vaccine preparations, a selection of effective adjuvants is nec...

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Autores principales:	A. N. Suvorov, G. F. Leontyeva, L. F. Meringova, K. B. Grabovskaya, T. V. Gupalova, E. I. Vorobyeva, A. S. Simbirtsev, A. A. Kolobov, Artem A. Totolian
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	recombinant vaccine immunogenicity adjuvants group b streptococci Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/5e2909d8e03f45c393bda86ef4319b67
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spelling	oai:doaj.org-article:5e2909d8e03f45c393bda86ef4319b672021-11-18T08:03:38ZEFFECTS OF DIFFERENT ADJUVANTS UPON IMMUNOGENICITY OF ANTI-GROUP B STREPTOCOCCAL VACCINE COMPONENTS1563-06252313-741X10.15789/1563-0625-2008-2-3-215-222https://doaj.org/article/5e2909d8e03f45c393bda86ef4319b672014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/149https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Design of an effective and safe vaccine against pathogenic streptococci is still on the agenda, in spite of numerous attempts in this area undertaken by different laboratories. In order to improve immunogenicity of recombinant vaccine preparations, a selection of effective adjuvants is necessary. Previously, two recombinant GBS polypeptides P6 and ScaAB were found to be immunogenic, and their injection in separate preparations or mixed manner boosted production of specific and protective antibodies with high affinity. Four different adjuvants (Freund adjuvant, aluminum hydroxide, Bestim and Interleukine-1β) have been tested for immunization of mice with single polypeptides, or with their mixtures. As a result of vaccination, it was demonstrated that aluminum hydroxide was providing the most desirable immunological parameters of immune response among the adjuvants tested. A mixture of polypeptides containing aluminum hydroxide was found to produce specific antibodies with better opsonizing activity against group B streptococci. (Med. Immunol., 2008, vol. 10, N 2-3, pp 215-222).A. N. SuvorovG. F. LeontyevaL. F. MeringovaK. B. GrabovskayaT. V. GupalovaE. I. VorobyevaA. S. SimbirtsevA. A. KolobovArtem A. TotolianSPb RAACIarticlerecombinant vaccineimmunogenicityadjuvantsgroup b streptococciImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 2-3, Pp 215-222 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	recombinant vaccine immunogenicity adjuvants group b streptococci Immunologic diseases. Allergy RC581-607
spellingShingle	recombinant vaccine immunogenicity adjuvants group b streptococci Immunologic diseases. Allergy RC581-607 A. N. Suvorov G. F. Leontyeva L. F. Meringova K. B. Grabovskaya T. V. Gupalova E. I. Vorobyeva A. S. Simbirtsev A. A. Kolobov Artem A. Totolian EFFECTS OF DIFFERENT ADJUVANTS UPON IMMUNOGENICITY OF ANTI-GROUP B STREPTOCOCCAL VACCINE COMPONENTS
description	Abstract. Design of an effective and safe vaccine against pathogenic streptococci is still on the agenda, in spite of numerous attempts in this area undertaken by different laboratories. In order to improve immunogenicity of recombinant vaccine preparations, a selection of effective adjuvants is necessary. Previously, two recombinant GBS polypeptides P6 and ScaAB were found to be immunogenic, and their injection in separate preparations or mixed manner boosted production of specific and protective antibodies with high affinity. Four different adjuvants (Freund adjuvant, aluminum hydroxide, Bestim and Interleukine-1β) have been tested for immunization of mice with single polypeptides, or with their mixtures. As a result of vaccination, it was demonstrated that aluminum hydroxide was providing the most desirable immunological parameters of immune response among the adjuvants tested. A mixture of polypeptides containing aluminum hydroxide was found to produce specific antibodies with better opsonizing activity against group B streptococci. (Med. Immunol., 2008, vol. 10, N 2-3, pp 215-222).
format	article
author	A. N. Suvorov G. F. Leontyeva L. F. Meringova K. B. Grabovskaya T. V. Gupalova E. I. Vorobyeva A. S. Simbirtsev A. A. Kolobov Artem A. Totolian
author_facet	A. N. Suvorov G. F. Leontyeva L. F. Meringova K. B. Grabovskaya T. V. Gupalova E. I. Vorobyeva A. S. Simbirtsev A. A. Kolobov Artem A. Totolian
author_sort	A. N. Suvorov
title	EFFECTS OF DIFFERENT ADJUVANTS UPON IMMUNOGENICITY OF ANTI-GROUP B STREPTOCOCCAL VACCINE COMPONENTS
title_short	EFFECTS OF DIFFERENT ADJUVANTS UPON IMMUNOGENICITY OF ANTI-GROUP B STREPTOCOCCAL VACCINE COMPONENTS
title_full	EFFECTS OF DIFFERENT ADJUVANTS UPON IMMUNOGENICITY OF ANTI-GROUP B STREPTOCOCCAL VACCINE COMPONENTS
title_fullStr	EFFECTS OF DIFFERENT ADJUVANTS UPON IMMUNOGENICITY OF ANTI-GROUP B STREPTOCOCCAL VACCINE COMPONENTS
title_full_unstemmed	EFFECTS OF DIFFERENT ADJUVANTS UPON IMMUNOGENICITY OF ANTI-GROUP B STREPTOCOCCAL VACCINE COMPONENTS
title_sort	effects of different adjuvants upon immunogenicity of anti-group b streptococcal vaccine components
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/5e2909d8e03f45c393bda86ef4319b67
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EFFECTS OF DIFFERENT ADJUVANTS UPON IMMUNOGENICITY OF ANTI-GROUP B STREPTOCOCCAL VACCINE COMPONENTS

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