Metabolically Healthy, but Obese Individuals and Associations with Echocardiographic Parameters and Inflammatory Biomarkers: Results from the CARLA Study

Ljupcho Efremov,1 Maria Elena Lacruz,2 Daniel Tiller,3 Daniel Medenwald,1 Karin Halina Greiser,4 Alexander Kluttig,1 Andreas Wienke,1 Sebastian Nuding,5 Rafael Mikolajczyk1 1Institute of Medical Epidemiology, Biostatistics, and Informatics (IMEBI), Interdisciplinary Center for Health Sciences, Medic...

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Autores principales:	Efremov L, Lacruz ME, Tiller D, Medenwald D, Greiser KH, Kluttig A, Wienke A, Nuding S, Mikolajczyk R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	obesity phenotypes visceral adipose tissue cardiac remodeling inflammatory biomarkers Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/5e29b5573b2846e7b7aa0b348fc057f9
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spelling	oai:doaj.org-article:5e29b5573b2846e7b7aa0b348fc057f92021-12-02T10:11:08ZMetabolically Healthy, but Obese Individuals and Associations with Echocardiographic Parameters and Inflammatory Biomarkers: Results from the CARLA Study1178-7007https://doaj.org/article/5e29b5573b2846e7b7aa0b348fc057f92020-07-01T00:00:00Zhttps://www.dovepress.com/metabolically-healthy-but-obese-individuals-and-associations-with-echo-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Ljupcho Efremov,1 Maria Elena Lacruz,2 Daniel Tiller,3 Daniel Medenwald,1 Karin Halina Greiser,4 Alexander Kluttig,1 Andreas Wienke,1 Sebastian Nuding,5 Rafael Mikolajczyk1 1Institute of Medical Epidemiology, Biostatistics, and Informatics (IMEBI), Interdisciplinary Center for Health Sciences, Medical School of the Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany; 2Clinical Cancer Register, Saxony-Anhalt, Halle (Saale), Germany; 3IT Department, Data Integration Center, University Hospital Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany; 4Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany; 5Department of Internal Medicine III, University Hospital Martin-Luther-University Halle-Wittenberg, Halle (Saale), GermanyCorrespondence: Rafael MikolajczykInstitute of Medical Epidemiology, Biostatistics, and Informatics (IMEBI), Interdisciplinary Center for Health Sciences, Medical School of the Martin-Luther-University Halle-Wittenberg, Magdeburger Str. 8, Halle (Saale) 06112, GermanyEmail rafael.mikolajczyk@uk-halle.deIntroduction: The research on heterogeneity among obese individuals has identified the metabolically healthy, but obese (MHO) phenotype as a distinct group that does not experience the typical cardiovascular-related diseases (CVD). It is unclear if this group differs with regard to preconditions for CVDs. Our aim was to assess differences in echocardiographic parameters and inflammatory biomarkers between MHO and metabolically healthy, normal weight individuals (MHNW).Methods: The analyses used data from 1412 elderly participants from a German population-based cohort study (CARLA), which collected detailed information on demographic, biochemical, and echocardiographic variables. Participants were subdivided into four groups (MHNW, MHO, MUNW (metabolically unhealthy, normal weight) and MUO (metabolically unhealthy, obese)) based on BMI≥ 30 kg/m2 (obese or normal weight) and presence of components of the metabolic syndrome. The clinical characteristics of the 4 groups were compared with ANOVA or Chi-Square test, in addition to two linear regression models for 16 echocardiographic parameters. The difference in inflammatory biomarkers (hsCRP, IL-6 and sTNF-RI) between the groups was examined with a multinomial logistic regression model.Results: The MHO individuals were on average 64.2± 8.4 years old, with a higher proportion of women (71.6%), low percentage of smokers, larger waist circumference (109.3± 10.5 cm vs 89.1± 10.8 cm, p< 0.0001) and higher odds ratios for hsCRP, IL-6 and sTNF-RI compared to MHNW individuals. Linear regression models revealed greater left atrial (LA) diameter (2.73 (95% CI: 1.35– 4.11) mm), LA volume (7.86 (95% CI: 2.88– 12.83) mL), and left ventricular mass index (LVMI) (11.82 (95% CI: 4.43– 19.22) g/m1.7) in the MHO group compared to the MHNW group.Conclusion: The MHO phenotype is associated with echocardiographic markers of cardiac remodeling (LA diameter, volume and LVMI) and higher odds ratios for inflammatory biomarkers.Keywords: obesity phenotypes, visceral adipose tissue, cardiac remodeling, inflammatory biomarkersEfremov LLacruz METiller DMedenwald DGreiser KHKluttig AWienke ANuding SMikolajczyk RDove Medical Pressarticleobesity phenotypesvisceral adipose tissuecardiac remodelinginflammatory biomarkersSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 2653-2665 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	obesity phenotypes visceral adipose tissue cardiac remodeling inflammatory biomarkers Specialties of internal medicine RC581-951
spellingShingle	obesity phenotypes visceral adipose tissue cardiac remodeling inflammatory biomarkers Specialties of internal medicine RC581-951 Efremov L Lacruz ME Tiller D Medenwald D Greiser KH Kluttig A Wienke A Nuding S Mikolajczyk R Metabolically Healthy, but Obese Individuals and Associations with Echocardiographic Parameters and Inflammatory Biomarkers: Results from the CARLA Study
description	Ljupcho Efremov,1 Maria Elena Lacruz,2 Daniel Tiller,3 Daniel Medenwald,1 Karin Halina Greiser,4 Alexander Kluttig,1 Andreas Wienke,1 Sebastian Nuding,5 Rafael Mikolajczyk1 1Institute of Medical Epidemiology, Biostatistics, and Informatics (IMEBI), Interdisciplinary Center for Health Sciences, Medical School of the Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany; 2Clinical Cancer Register, Saxony-Anhalt, Halle (Saale), Germany; 3IT Department, Data Integration Center, University Hospital Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany; 4Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany; 5Department of Internal Medicine III, University Hospital Martin-Luther-University Halle-Wittenberg, Halle (Saale), GermanyCorrespondence: Rafael MikolajczykInstitute of Medical Epidemiology, Biostatistics, and Informatics (IMEBI), Interdisciplinary Center for Health Sciences, Medical School of the Martin-Luther-University Halle-Wittenberg, Magdeburger Str. 8, Halle (Saale) 06112, GermanyEmail rafael.mikolajczyk@uk-halle.deIntroduction: The research on heterogeneity among obese individuals has identified the metabolically healthy, but obese (MHO) phenotype as a distinct group that does not experience the typical cardiovascular-related diseases (CVD). It is unclear if this group differs with regard to preconditions for CVDs. Our aim was to assess differences in echocardiographic parameters and inflammatory biomarkers between MHO and metabolically healthy, normal weight individuals (MHNW).Methods: The analyses used data from 1412 elderly participants from a German population-based cohort study (CARLA), which collected detailed information on demographic, biochemical, and echocardiographic variables. Participants were subdivided into four groups (MHNW, MHO, MUNW (metabolically unhealthy, normal weight) and MUO (metabolically unhealthy, obese)) based on BMI≥ 30 kg/m2 (obese or normal weight) and presence of components of the metabolic syndrome. The clinical characteristics of the 4 groups were compared with ANOVA or Chi-Square test, in addition to two linear regression models for 16 echocardiographic parameters. The difference in inflammatory biomarkers (hsCRP, IL-6 and sTNF-RI) between the groups was examined with a multinomial logistic regression model.Results: The MHO individuals were on average 64.2± 8.4 years old, with a higher proportion of women (71.6%), low percentage of smokers, larger waist circumference (109.3± 10.5 cm vs 89.1± 10.8 cm, p< 0.0001) and higher odds ratios for hsCRP, IL-6 and sTNF-RI compared to MHNW individuals. Linear regression models revealed greater left atrial (LA) diameter (2.73 (95% CI: 1.35– 4.11) mm), LA volume (7.86 (95% CI: 2.88– 12.83) mL), and left ventricular mass index (LVMI) (11.82 (95% CI: 4.43– 19.22) g/m1.7) in the MHO group compared to the MHNW group.Conclusion: The MHO phenotype is associated with echocardiographic markers of cardiac remodeling (LA diameter, volume and LVMI) and higher odds ratios for inflammatory biomarkers.Keywords: obesity phenotypes, visceral adipose tissue, cardiac remodeling, inflammatory biomarkers
format	article
author	Efremov L Lacruz ME Tiller D Medenwald D Greiser KH Kluttig A Wienke A Nuding S Mikolajczyk R
author_facet	Efremov L Lacruz ME Tiller D Medenwald D Greiser KH Kluttig A Wienke A Nuding S Mikolajczyk R
author_sort	Efremov L
title	Metabolically Healthy, but Obese Individuals and Associations with Echocardiographic Parameters and Inflammatory Biomarkers: Results from the CARLA Study
title_short	Metabolically Healthy, but Obese Individuals and Associations with Echocardiographic Parameters and Inflammatory Biomarkers: Results from the CARLA Study
title_full	Metabolically Healthy, but Obese Individuals and Associations with Echocardiographic Parameters and Inflammatory Biomarkers: Results from the CARLA Study
title_fullStr	Metabolically Healthy, but Obese Individuals and Associations with Echocardiographic Parameters and Inflammatory Biomarkers: Results from the CARLA Study
title_full_unstemmed	Metabolically Healthy, but Obese Individuals and Associations with Echocardiographic Parameters and Inflammatory Biomarkers: Results from the CARLA Study
title_sort	metabolically healthy, but obese individuals and associations with echocardiographic parameters and inflammatory biomarkers: results from the carla study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/5e29b5573b2846e7b7aa0b348fc057f9
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Metabolically Healthy, but Obese Individuals and Associations with Echocardiographic Parameters and Inflammatory Biomarkers: Results from the CARLA Study

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