The structure of behavioral variation within a genotype
Individual animals vary in their behaviors. This is true even when they share the same genotype and were reared in the same environment. Clusters of covarying behaviors constitute behavioral syndromes, and an individual’s position along such axes of covariation is a representation of their personali...
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eLife Sciences Publications Ltd
2021
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oai:doaj.org-article:5e2a96f350a24d2a9a4797b685be77bd2021-11-15T05:40:17ZThe structure of behavioral variation within a genotype10.7554/eLife.649882050-084Xe64988https://doaj.org/article/5e2a96f350a24d2a9a4797b685be77bd2021-10-01T00:00:00Zhttps://elifesciences.org/articles/64988https://doaj.org/toc/2050-084XIndividual animals vary in their behaviors. This is true even when they share the same genotype and were reared in the same environment. Clusters of covarying behaviors constitute behavioral syndromes, and an individual’s position along such axes of covariation is a representation of their personality. Despite these conceptual frameworks, the structure of behavioral covariation within a genotype is essentially uncharacterized and its mechanistic origins unknown. Passing hundreds of inbred Drosophila individuals through an experimental pipeline that captured hundreds of behavioral measures, we found sparse but significant correlations among small sets of behaviors. Thus, the space of behavioral variation has many independent dimensions. Manipulating the physiology of the brain, and specific neural populations, altered specific correlations. We also observed that variation in gene expression can predict an individual’s position on some behavioral axes. This work represents the first steps in understanding the biological mechanisms determining the structure of behavioral variation within a genotype.Zachary WerkhovenAlyssa BravinKyobi Skutt-KakariaPablo ReimersLuisa F PallaresJulien AyrolesBenjamin L de BivorteLife Sciences Publications Ltdarticlehigh-throughput behaviorinvdividualitypersonalitycovariationneural circuitstranscriptomicsMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
high-throughput behavior invdividuality personality covariation neural circuits transcriptomics Medicine R Science Q Biology (General) QH301-705.5 |
| spellingShingle |
high-throughput behavior invdividuality personality covariation neural circuits transcriptomics Medicine R Science Q Biology (General) QH301-705.5 Zachary Werkhoven Alyssa Bravin Kyobi Skutt-Kakaria Pablo Reimers Luisa F Pallares Julien Ayroles Benjamin L de Bivort The structure of behavioral variation within a genotype |
| description |
Individual animals vary in their behaviors. This is true even when they share the same genotype and were reared in the same environment. Clusters of covarying behaviors constitute behavioral syndromes, and an individual’s position along such axes of covariation is a representation of their personality. Despite these conceptual frameworks, the structure of behavioral covariation within a genotype is essentially uncharacterized and its mechanistic origins unknown. Passing hundreds of inbred Drosophila individuals through an experimental pipeline that captured hundreds of behavioral measures, we found sparse but significant correlations among small sets of behaviors. Thus, the space of behavioral variation has many independent dimensions. Manipulating the physiology of the brain, and specific neural populations, altered specific correlations. We also observed that variation in gene expression can predict an individual’s position on some behavioral axes. This work represents the first steps in understanding the biological mechanisms determining the structure of behavioral variation within a genotype. |
| format |
article |
| author |
Zachary Werkhoven Alyssa Bravin Kyobi Skutt-Kakaria Pablo Reimers Luisa F Pallares Julien Ayroles Benjamin L de Bivort |
| author_facet |
Zachary Werkhoven Alyssa Bravin Kyobi Skutt-Kakaria Pablo Reimers Luisa F Pallares Julien Ayroles Benjamin L de Bivort |
| author_sort |
Zachary Werkhoven |
| title |
The structure of behavioral variation within a genotype |
| title_short |
The structure of behavioral variation within a genotype |
| title_full |
The structure of behavioral variation within a genotype |
| title_fullStr |
The structure of behavioral variation within a genotype |
| title_full_unstemmed |
The structure of behavioral variation within a genotype |
| title_sort |
structure of behavioral variation within a genotype |
| publisher |
eLife Sciences Publications Ltd |
| publishDate |
2021 |
| url |
https://doaj.org/article/5e2a96f350a24d2a9a4797b685be77bd |
| work_keys_str_mv |
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1718428554848370688 |