The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus
Resistance to primary treatments of invasive aspergillosis is growing. Here, the authors generate a knockout library for 484 transcription factors in Aspergillus fumigatus, and show that loss of the NCT complex leads to cross-resistance to all primary and some salvage therapeutics without affecting...
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Nature Portfolio
2020
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oai:doaj.org-article:5e2ad52f5b324f87841175e72f74a7dd2021-12-02T17:31:09ZThe negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus10.1038/s41467-019-14191-12041-1723https://doaj.org/article/5e2ad52f5b324f87841175e72f74a7dd2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14191-1https://doaj.org/toc/2041-1723Resistance to primary treatments of invasive aspergillosis is growing. Here, the authors generate a knockout library for 484 transcription factors in Aspergillus fumigatus, and show that loss of the NCT complex leads to cross-resistance to all primary and some salvage therapeutics without affecting pathogenicity.Takanori FurukawaNorman van RhijnMarcin FraczekFabio GsallerEmma DaviesPaul CarrSara GagoRachael Fortune-GrantSayema RahmanJane Mabey GilsenanEmma HoulderCaitlin H. KowalskiShriya RajSanjoy PaulPeter CookJosie E. ParkerSteve KellyRobert A. CramerJean-Paul LatgéScott Moye-RowleyElaine BignellPaul BowyerMichael J. BromleyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020) |
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| topic |
Science Q |
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Science Q Takanori Furukawa Norman van Rhijn Marcin Fraczek Fabio Gsaller Emma Davies Paul Carr Sara Gago Rachael Fortune-Grant Sayema Rahman Jane Mabey Gilsenan Emma Houlder Caitlin H. Kowalski Shriya Raj Sanjoy Paul Peter Cook Josie E. Parker Steve Kelly Robert A. Cramer Jean-Paul Latgé Scott Moye-Rowley Elaine Bignell Paul Bowyer Michael J. Bromley The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus |
| description |
Resistance to primary treatments of invasive aspergillosis is growing. Here, the authors generate a knockout library for 484 transcription factors in Aspergillus fumigatus, and show that loss of the NCT complex leads to cross-resistance to all primary and some salvage therapeutics without affecting pathogenicity. |
| format |
article |
| author |
Takanori Furukawa Norman van Rhijn Marcin Fraczek Fabio Gsaller Emma Davies Paul Carr Sara Gago Rachael Fortune-Grant Sayema Rahman Jane Mabey Gilsenan Emma Houlder Caitlin H. Kowalski Shriya Raj Sanjoy Paul Peter Cook Josie E. Parker Steve Kelly Robert A. Cramer Jean-Paul Latgé Scott Moye-Rowley Elaine Bignell Paul Bowyer Michael J. Bromley |
| author_facet |
Takanori Furukawa Norman van Rhijn Marcin Fraczek Fabio Gsaller Emma Davies Paul Carr Sara Gago Rachael Fortune-Grant Sayema Rahman Jane Mabey Gilsenan Emma Houlder Caitlin H. Kowalski Shriya Raj Sanjoy Paul Peter Cook Josie E. Parker Steve Kelly Robert A. Cramer Jean-Paul Latgé Scott Moye-Rowley Elaine Bignell Paul Bowyer Michael J. Bromley |
| author_sort |
Takanori Furukawa |
| title |
The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus |
| title_short |
The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus |
| title_full |
The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus |
| title_fullStr |
The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus |
| title_full_unstemmed |
The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus |
| title_sort |
negative cofactor 2 complex is a key regulator of drug resistance in aspergillus fumigatus |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/5e2ad52f5b324f87841175e72f74a7dd |
| work_keys_str_mv |
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