The role of heat shock proteins in neoplastic processes and the research on their importance in the diagnosis and treatment of cancer

Heat shock proteins (HSPs) are chaperones with highly conservative primary structure, necessary in the processes of protein folding to the most energetically advantageous conformation and maintaining their stability. HSPs perform a number of important functions in various cellular processes and are...

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Autores principales:	Iryna Boliukh, Agnieszka Rombel-Bryzek, Olga Żuk, Barbara Radecka
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2021
Materias:	cancer heat shock proteins apoptosis anti-cancer therapy. Medicine R
Acceso en línea:	https://doaj.org/article/5e2e67144ddc47cd95c751d32efd7445
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spelling	oai:doaj.org-article:5e2e67144ddc47cd95c751d32efd74452021-12-02T17:45:53ZThe role of heat shock proteins in neoplastic processes and the research on their importance in the diagnosis and treatment of cancer1428-25261897-430910.5114/wo.2021.106006https://doaj.org/article/5e2e67144ddc47cd95c751d32efd74452021-05-01T00:00:00Zhttps://www.termedia.pl/The-role-of-heat-shock-proteins-in-neoplastic-processes-and-the-research-on-their-importance-in-the-diagnosis-and-treatment-of-cancer,3,44027,1,1.htmlhttps://doaj.org/toc/1428-2526https://doaj.org/toc/1897-4309Heat shock proteins (HSPs) are chaperones with highly conservative primary structure, necessary in the processes of protein folding to the most energetically advantageous conformation and maintaining their stability. HSPs perform a number of important functions in various cellular processes and are capable of modulating pathophysiological conditions at the cellular and systemic levels. An example is the high level of HSP expression in neoplastic tissues, which disrupts the apoptosis of transformed cells and promotes the processes of proliferation, invasion, and metastasis. In addition, an increasing amount of information is appearing about the participation of HSPs in the formation of multidrug resistance.This paper provides a review of the current state of research on the fundamental importance as well as the diagnostic and prognostic role of various classes of HSP in cancer treatment. It presents the prospects for using HSPs as biological markers of disease progression and targets in various cancer treatment strategies. However, the need for additional research is quite high. Only numerous joint efforts of research groups will allow the effective use of HSPs as a tool to combat cancer.Iryna BoliukhAgnieszka Rombel-BryzekOlga ŻukBarbara RadeckaTermedia Publishing Housearticlecancer heat shock proteins apoptosis anti-cancer therapy.MedicineRENContemporary Oncology, Vol 25, Iss 2, Pp 73-79 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer heat shock proteins apoptosis anti-cancer therapy. Medicine R
spellingShingle	cancer heat shock proteins apoptosis anti-cancer therapy. Medicine R Iryna Boliukh Agnieszka Rombel-Bryzek Olga Żuk Barbara Radecka The role of heat shock proteins in neoplastic processes and the research on their importance in the diagnosis and treatment of cancer
description	Heat shock proteins (HSPs) are chaperones with highly conservative primary structure, necessary in the processes of protein folding to the most energetically advantageous conformation and maintaining their stability. HSPs perform a number of important functions in various cellular processes and are capable of modulating pathophysiological conditions at the cellular and systemic levels. An example is the high level of HSP expression in neoplastic tissues, which disrupts the apoptosis of transformed cells and promotes the processes of proliferation, invasion, and metastasis. In addition, an increasing amount of information is appearing about the participation of HSPs in the formation of multidrug resistance.This paper provides a review of the current state of research on the fundamental importance as well as the diagnostic and prognostic role of various classes of HSP in cancer treatment. It presents the prospects for using HSPs as biological markers of disease progression and targets in various cancer treatment strategies. However, the need for additional research is quite high. Only numerous joint efforts of research groups will allow the effective use of HSPs as a tool to combat cancer.
format	article
author	Iryna Boliukh Agnieszka Rombel-Bryzek Olga Żuk Barbara Radecka
author_facet	Iryna Boliukh Agnieszka Rombel-Bryzek Olga Żuk Barbara Radecka
author_sort	Iryna Boliukh
title	The role of heat shock proteins in neoplastic processes and the research on their importance in the diagnosis and treatment of cancer
title_short	The role of heat shock proteins in neoplastic processes and the research on their importance in the diagnosis and treatment of cancer
title_full	The role of heat shock proteins in neoplastic processes and the research on their importance in the diagnosis and treatment of cancer
title_fullStr	The role of heat shock proteins in neoplastic processes and the research on their importance in the diagnosis and treatment of cancer
title_full_unstemmed	The role of heat shock proteins in neoplastic processes and the research on their importance in the diagnosis and treatment of cancer
title_sort	role of heat shock proteins in neoplastic processes and the research on their importance in the diagnosis and treatment of cancer
publisher	Termedia Publishing House
publishDate	2021
url	https://doaj.org/article/5e2e67144ddc47cd95c751d32efd7445
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The role of heat shock proteins in neoplastic processes and the research on their importance in the diagnosis and treatment of cancer

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