Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins

Protein degradation in clinical samples is largely unexplored. Here, the authors analyze the transcriptome and proteome of clinical tissue samples and develop an algorithm to assess protein degradation, showing that protein degradation is negligible in most tissue samples and does not correlate with...

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Autores principales:	Wenguang Shao, Tiannan Guo, Nora C. Toussaint, Peng Xue, Ulrich Wagner, Li Li, Konstantina Charmpi, Yi Zhu, Jianmin Wu, Marija Buljan, Rui Sun, Dorothea Rutishauser, Thomas Hermanns, Christian Daniel Fankhauser, Cedric Poyet, Jelena Ljubicic, Niels Rupp, Jan H. Rüschoff, Qing Zhong, Andreas Beyer, Jiafu Ji, Ben C. Collins, Yansheng Liu, Gunnar Rätsch, Peter J. Wild, Ruedi Aebersold
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5e2fad9e30374816bb16c6dcb2619e1f
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spelling	oai:doaj.org-article:5e2fad9e30374816bb16c6dcb2619e1f2021-12-02T15:36:04ZComparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins10.1038/s41467-019-10513-52041-1723https://doaj.org/article/5e2fad9e30374816bb16c6dcb2619e1f2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10513-5https://doaj.org/toc/2041-1723Protein degradation in clinical samples is largely unexplored. Here, the authors analyze the transcriptome and proteome of clinical tissue samples and develop an algorithm to assess protein degradation, showing that protein degradation is negligible in most tissue samples and does not correlate with transcript degradation.Wenguang ShaoTiannan GuoNora C. ToussaintPeng XueUlrich WagnerLi LiKonstantina CharmpiYi ZhuJianmin WuMarija BuljanRui SunDorothea RutishauserThomas HermannsChristian Daniel FankhauserCedric PoyetJelena LjubicicNiels RuppJan H. RüschoffQing ZhongAndreas BeyerJiafu JiBen C. CollinsYansheng LiuGunnar RätschPeter J. WildRuedi AebersoldNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenguang Shao Tiannan Guo Nora C. Toussaint Peng Xue Ulrich Wagner Li Li Konstantina Charmpi Yi Zhu Jianmin Wu Marija Buljan Rui Sun Dorothea Rutishauser Thomas Hermanns Christian Daniel Fankhauser Cedric Poyet Jelena Ljubicic Niels Rupp Jan H. Rüschoff Qing Zhong Andreas Beyer Jiafu Ji Ben C. Collins Yansheng Liu Gunnar Rätsch Peter J. Wild Ruedi Aebersold Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins
description	Protein degradation in clinical samples is largely unexplored. Here, the authors analyze the transcriptome and proteome of clinical tissue samples and develop an algorithm to assess protein degradation, showing that protein degradation is negligible in most tissue samples and does not correlate with transcript degradation.
format	article
author	Wenguang Shao Tiannan Guo Nora C. Toussaint Peng Xue Ulrich Wagner Li Li Konstantina Charmpi Yi Zhu Jianmin Wu Marija Buljan Rui Sun Dorothea Rutishauser Thomas Hermanns Christian Daniel Fankhauser Cedric Poyet Jelena Ljubicic Niels Rupp Jan H. Rüschoff Qing Zhong Andreas Beyer Jiafu Ji Ben C. Collins Yansheng Liu Gunnar Rätsch Peter J. Wild Ruedi Aebersold
author_facet	Wenguang Shao Tiannan Guo Nora C. Toussaint Peng Xue Ulrich Wagner Li Li Konstantina Charmpi Yi Zhu Jianmin Wu Marija Buljan Rui Sun Dorothea Rutishauser Thomas Hermanns Christian Daniel Fankhauser Cedric Poyet Jelena Ljubicic Niels Rupp Jan H. Rüschoff Qing Zhong Andreas Beyer Jiafu Ji Ben C. Collins Yansheng Liu Gunnar Rätsch Peter J. Wild Ruedi Aebersold
author_sort	Wenguang Shao
title	Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins
title_short	Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins
title_full	Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins
title_fullStr	Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins
title_full_unstemmed	Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins
title_sort	comparative analysis of mrna and protein degradation in prostate tissues indicates high stability of proteins
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5e2fad9e30374816bb16c6dcb2619e1f
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Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins

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