A Novel Para-Amino Salicylic Acid Magnesium Layered Hydroxide Nanocomposite Anti-Tuberculosis Drug Delivery System with Enhanced in vitro Therapeutic and Anti-Inflammatory Properties

Bullo Saifullah,1,2 Palanisamy Arulselvan,3,4 Mohamed E El Zowalaty,3,5 Woan Sean Tan,3 Sharida Fakurazi,6 Thomas J Webster,7 Rabia Baby,1 Mohd Zobir Hussein1 1Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, Serdang, Selangor,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Saifullah B, Arulselvan P, El Zowalaty ME, Tan WS, Fakurazi S, Webster TJ, Baby R, Hussein MZ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	magnesium layered hydroxides biomaterial sustained release anti-tuberculosis anti-inflammatory. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5e30e778381c4b7f982f8db570055e3d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5e30e778381c4b7f982f8db570055e3d
record_format	dspace
spelling	oai:doaj.org-article:5e30e778381c4b7f982f8db570055e3d2021-12-02T19:19:52ZA Novel Para-Amino Salicylic Acid Magnesium Layered Hydroxide Nanocomposite Anti-Tuberculosis Drug Delivery System with Enhanced in vitro Therapeutic and Anti-Inflammatory Properties1178-2013https://doaj.org/article/5e30e778381c4b7f982f8db570055e3d2021-10-01T00:00:00Zhttps://www.dovepress.com/a-novel-para-amino-salicylic-acid-magnesium-layered-hydroxide-nanocomp-peer-reviewed-fulltext-article-IJNhttps://doaj.org/toc/1178-2013Bullo Saifullah,1,2 Palanisamy Arulselvan,3,4 Mohamed E El Zowalaty,3,5 Woan Sean Tan,3 Sharida Fakurazi,6 Thomas J Webster,7 Rabia Baby,1 Mohd Zobir Hussein1 1Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, Serdang, Selangor, Malaysia; 2Department of Management Sciences and Technology, The Begum Nusrat Bhutto Women University Sukkur, Sukkur, Sindh, 65170, Pakistan; 3Laboratory for Vaccine and Immunotherapeutics, Institute of Biosciences, University Putra Malaysia, Serdang, Selangor, 43400, Malaysia; 4Muthayammal Centre for Advanced Research, Muthayammal College of Arts and Science, Namakkal, Tamil Nadu, 637408, India; 5Zoonosis Science Center, Department of Microbiology and Immunology, Uppsala University, Uppsala, Sweden; 6Department of Human Anatomy, Faculty of Medicine and Health Science, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; 7Department of Chemical Engineering, Northeastern University, Boston, MA, USACorrespondence: Mohd Zobir HusseinMaterials Synthesis and Characterization Laboratory, Institute of Advanced Technology, (ITMA), Universiti Putra Malaysia, Serdang, Selangor, MalaysiaTel +60 397698092Email mzobir@upm.edu.myIntroduction: Mycobacterium tuberculosis infections are associated with severe local inflammatory reactions, which may be life-threatening and lead to tuberculosis pathogenesis and associated complications. Inorganic nanolayers have been vastly exploited for biomedical applications (especially in drug delivery) because of their biocompatible and biodegradable nature with the ability to release a drug in a sustained manner. Herein, we report a new nanodelivery system of inorganic nanolayers based on magnesium layered hydroxides (MgLH) and a successfully intercalated anti-tuberculosis drug para-aminosalicylic acid (PAS).Methods: The designed anti-tuberculosis nanodelivery composite, MgLH-PAS, was prepared by a novel co-precipitation method using MgNO3 as well MgO as starting materials.Results: The designed nano-formulation, PAS-MgLH, showed good antimycobacterial and antimicrobial activities with significant synergistic anti-inflammatory effects on the suppression of lipopolysaccharide (LPS) stimulated inflammatory mediators in RAW 264.7 macrophages. The designed nano-formulation was also found to be biocompatible with human normal lung cells (MRC-5) and 3T3 fibroblast cells. Furthermore, the in vitro release of PAS from PAS-MgLH was found to be sustained in human body simulated phosphate buffer saline (PBS) solutions of pH 7.4 and pH 4.8.Discussion: The results of the present study are highly encouraging for further in vivo studies. This new nanodelivery system, MgLH, can be exploited in the delivery of other drugs and in numerous other biomedical applications as well.Keywords: Mycobacterium tuberculosis, magnesium layered hydroxides, biomaterial, sustained release, anti-tuberculosis, anti-inflammatorySaifullah BArulselvan PEl Zowalaty METan WSFakurazi SWebster TJBaby RHussein MZDove Medical Pressarticlemagnesium layered hydroxidesbiomaterialsustained releaseanti-tuberculosisanti-inflammatory.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 7035-7050 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	magnesium layered hydroxides biomaterial sustained release anti-tuberculosis anti-inflammatory. Medicine (General) R5-920
spellingShingle	magnesium layered hydroxides biomaterial sustained release anti-tuberculosis anti-inflammatory. Medicine (General) R5-920 Saifullah B Arulselvan P El Zowalaty ME Tan WS Fakurazi S Webster TJ Baby R Hussein MZ A Novel Para-Amino Salicylic Acid Magnesium Layered Hydroxide Nanocomposite Anti-Tuberculosis Drug Delivery System with Enhanced in vitro Therapeutic and Anti-Inflammatory Properties
description	Bullo Saifullah,1,2 Palanisamy Arulselvan,3,4 Mohamed E El Zowalaty,3,5 Woan Sean Tan,3 Sharida Fakurazi,6 Thomas J Webster,7 Rabia Baby,1 Mohd Zobir Hussein1 1Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, Serdang, Selangor, Malaysia; 2Department of Management Sciences and Technology, The Begum Nusrat Bhutto Women University Sukkur, Sukkur, Sindh, 65170, Pakistan; 3Laboratory for Vaccine and Immunotherapeutics, Institute of Biosciences, University Putra Malaysia, Serdang, Selangor, 43400, Malaysia; 4Muthayammal Centre for Advanced Research, Muthayammal College of Arts and Science, Namakkal, Tamil Nadu, 637408, India; 5Zoonosis Science Center, Department of Microbiology and Immunology, Uppsala University, Uppsala, Sweden; 6Department of Human Anatomy, Faculty of Medicine and Health Science, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; 7Department of Chemical Engineering, Northeastern University, Boston, MA, USACorrespondence: Mohd Zobir HusseinMaterials Synthesis and Characterization Laboratory, Institute of Advanced Technology, (ITMA), Universiti Putra Malaysia, Serdang, Selangor, MalaysiaTel +60 397698092Email mzobir@upm.edu.myIntroduction: Mycobacterium tuberculosis infections are associated with severe local inflammatory reactions, which may be life-threatening and lead to tuberculosis pathogenesis and associated complications. Inorganic nanolayers have been vastly exploited for biomedical applications (especially in drug delivery) because of their biocompatible and biodegradable nature with the ability to release a drug in a sustained manner. Herein, we report a new nanodelivery system of inorganic nanolayers based on magnesium layered hydroxides (MgLH) and a successfully intercalated anti-tuberculosis drug para-aminosalicylic acid (PAS).Methods: The designed anti-tuberculosis nanodelivery composite, MgLH-PAS, was prepared by a novel co-precipitation method using MgNO3 as well MgO as starting materials.Results: The designed nano-formulation, PAS-MgLH, showed good antimycobacterial and antimicrobial activities with significant synergistic anti-inflammatory effects on the suppression of lipopolysaccharide (LPS) stimulated inflammatory mediators in RAW 264.7 macrophages. The designed nano-formulation was also found to be biocompatible with human normal lung cells (MRC-5) and 3T3 fibroblast cells. Furthermore, the in vitro release of PAS from PAS-MgLH was found to be sustained in human body simulated phosphate buffer saline (PBS) solutions of pH 7.4 and pH 4.8.Discussion: The results of the present study are highly encouraging for further in vivo studies. This new nanodelivery system, MgLH, can be exploited in the delivery of other drugs and in numerous other biomedical applications as well.Keywords: Mycobacterium tuberculosis, magnesium layered hydroxides, biomaterial, sustained release, anti-tuberculosis, anti-inflammatory
format	article
author	Saifullah B Arulselvan P El Zowalaty ME Tan WS Fakurazi S Webster TJ Baby R Hussein MZ
author_facet	Saifullah B Arulselvan P El Zowalaty ME Tan WS Fakurazi S Webster TJ Baby R Hussein MZ
author_sort	Saifullah B
title	A Novel Para-Amino Salicylic Acid Magnesium Layered Hydroxide Nanocomposite Anti-Tuberculosis Drug Delivery System with Enhanced in vitro Therapeutic and Anti-Inflammatory Properties
title_short	A Novel Para-Amino Salicylic Acid Magnesium Layered Hydroxide Nanocomposite Anti-Tuberculosis Drug Delivery System with Enhanced in vitro Therapeutic and Anti-Inflammatory Properties
title_full	A Novel Para-Amino Salicylic Acid Magnesium Layered Hydroxide Nanocomposite Anti-Tuberculosis Drug Delivery System with Enhanced in vitro Therapeutic and Anti-Inflammatory Properties
title_fullStr	A Novel Para-Amino Salicylic Acid Magnesium Layered Hydroxide Nanocomposite Anti-Tuberculosis Drug Delivery System with Enhanced in vitro Therapeutic and Anti-Inflammatory Properties
title_full_unstemmed	A Novel Para-Amino Salicylic Acid Magnesium Layered Hydroxide Nanocomposite Anti-Tuberculosis Drug Delivery System with Enhanced in vitro Therapeutic and Anti-Inflammatory Properties
title_sort	novel para-amino salicylic acid magnesium layered hydroxide nanocomposite anti-tuberculosis drug delivery system with enhanced in vitro therapeutic and anti-inflammatory properties
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/5e30e778381c4b7f982f8db570055e3d
work_keys_str_mv	AT saifullahb anovelparaaminosalicylicacidmagnesiumlayeredhydroxidenanocompositeantituberculosisdrugdeliverysystemwithenhancedinvitrotherapeuticandantiinflammatoryproperties AT arulselvanp anovelparaaminosalicylicacidmagnesiumlayeredhydroxidenanocompositeantituberculosisdrugdeliverysystemwithenhancedinvitrotherapeuticandantiinflammatoryproperties AT elzowalatyme anovelparaaminosalicylicacidmagnesiumlayeredhydroxidenanocompositeantituberculosisdrugdeliverysystemwithenhancedinvitrotherapeuticandantiinflammatoryproperties AT tanws anovelparaaminosalicylicacidmagnesiumlayeredhydroxidenanocompositeantituberculosisdrugdeliverysystemwithenhancedinvitrotherapeuticandantiinflammatoryproperties AT fakurazis anovelparaaminosalicylicacidmagnesiumlayeredhydroxidenanocompositeantituberculosisdrugdeliverysystemwithenhancedinvitrotherapeuticandantiinflammatoryproperties AT webstertj anovelparaaminosalicylicacidmagnesiumlayeredhydroxidenanocompositeantituberculosisdrugdeliverysystemwithenhancedinvitrotherapeuticandantiinflammatoryproperties AT babyr anovelparaaminosalicylicacidmagnesiumlayeredhydroxidenanocompositeantituberculosisdrugdeliverysystemwithenhancedinvitrotherapeuticandantiinflammatoryproperties AT husseinmz anovelparaaminosalicylicacidmagnesiumlayeredhydroxidenanocompositeantituberculosisdrugdeliverysystemwithenhancedinvitrotherapeuticandantiinflammatoryproperties AT saifullahb novelparaaminosalicylicacidmagnesiumlayeredhydroxidenanocompositeantituberculosisdrugdeliverysystemwithenhancedinvitrotherapeuticandantiinflammatoryproperties AT arulselvanp novelparaaminosalicylicacidmagnesiumlayeredhydroxidenanocompositeantituberculosisdrugdeliverysystemwithenhancedinvitrotherapeuticandantiinflammatoryproperties AT elzowalatyme novelparaaminosalicylicacidmagnesiumlayeredhydroxidenanocompositeantituberculosisdrugdeliverysystemwithenhancedinvitrotherapeuticandantiinflammatoryproperties AT tanws novelparaaminosalicylicacidmagnesiumlayeredhydroxidenanocompositeantituberculosisdrugdeliverysystemwithenhancedinvitrotherapeuticandantiinflammatoryproperties AT fakurazis novelparaaminosalicylicacidmagnesiumlayeredhydroxidenanocompositeantituberculosisdrugdeliverysystemwithenhancedinvitrotherapeuticandantiinflammatoryproperties AT webstertj novelparaaminosalicylicacidmagnesiumlayeredhydroxidenanocompositeantituberculosisdrugdeliverysystemwithenhancedinvitrotherapeuticandantiinflammatoryproperties AT babyr novelparaaminosalicylicacidmagnesiumlayeredhydroxidenanocompositeantituberculosisdrugdeliverysystemwithenhancedinvitrotherapeuticandantiinflammatoryproperties AT husseinmz novelparaaminosalicylicacidmagnesiumlayeredhydroxidenanocompositeantituberculosisdrugdeliverysystemwithenhancedinvitrotherapeuticandantiinflammatoryproperties
_version_	1718376854332637184

A Novel Para-Amino Salicylic Acid Magnesium Layered Hydroxide Nanocomposite Anti-Tuberculosis Drug Delivery System with Enhanced in vitro Therapeutic and Anti-Inflammatory Properties

Ejemplares similares