Mechanism of Rad26-assisted rescue of stalled RNA polymerase II in transcription-coupled repair

Here the authors provide models of RNA polymerase II bound to the yeast CSB ortholog Rad26 in different nucleotide states; explain how Rad26 domain motions help the polymerase progress past DNA lesions; and interpret the effects of CSB-associated disease mutations.

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Autores principales:	Chunli Yan, Thomas Dodd, Jina Yu, Bernice Leung, Jun Xu, Juntaek Oh, Dong Wang, Ivaylo Ivanov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5e33c934a5cc481e9029a08bb4340ef4
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spelling	oai:doaj.org-article:5e33c934a5cc481e9029a08bb4340ef42021-12-05T12:22:53ZMechanism of Rad26-assisted rescue of stalled RNA polymerase II in transcription-coupled repair10.1038/s41467-021-27295-42041-1723https://doaj.org/article/5e33c934a5cc481e9029a08bb4340ef42021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27295-4https://doaj.org/toc/2041-1723Here the authors provide models of RNA polymerase II bound to the yeast CSB ortholog Rad26 in different nucleotide states; explain how Rad26 domain motions help the polymerase progress past DNA lesions; and interpret the effects of CSB-associated disease mutations.Chunli YanThomas DoddJina YuBernice LeungJun XuJuntaek OhDong WangIvaylo IvanovNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chunli Yan Thomas Dodd Jina Yu Bernice Leung Jun Xu Juntaek Oh Dong Wang Ivaylo Ivanov Mechanism of Rad26-assisted rescue of stalled RNA polymerase II in transcription-coupled repair
description	Here the authors provide models of RNA polymerase II bound to the yeast CSB ortholog Rad26 in different nucleotide states; explain how Rad26 domain motions help the polymerase progress past DNA lesions; and interpret the effects of CSB-associated disease mutations.
format	article
author	Chunli Yan Thomas Dodd Jina Yu Bernice Leung Jun Xu Juntaek Oh Dong Wang Ivaylo Ivanov
author_facet	Chunli Yan Thomas Dodd Jina Yu Bernice Leung Jun Xu Juntaek Oh Dong Wang Ivaylo Ivanov
author_sort	Chunli Yan
title	Mechanism of Rad26-assisted rescue of stalled RNA polymerase II in transcription-coupled repair
title_short	Mechanism of Rad26-assisted rescue of stalled RNA polymerase II in transcription-coupled repair
title_full	Mechanism of Rad26-assisted rescue of stalled RNA polymerase II in transcription-coupled repair
title_fullStr	Mechanism of Rad26-assisted rescue of stalled RNA polymerase II in transcription-coupled repair
title_full_unstemmed	Mechanism of Rad26-assisted rescue of stalled RNA polymerase II in transcription-coupled repair
title_sort	mechanism of rad26-assisted rescue of stalled rna polymerase ii in transcription-coupled repair
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5e33c934a5cc481e9029a08bb4340ef4
work_keys_str_mv	AT chunliyan mechanismofrad26assistedrescueofstalledrnapolymeraseiiintranscriptioncoupledrepair AT thomasdodd mechanismofrad26assistedrescueofstalledrnapolymeraseiiintranscriptioncoupledrepair AT jinayu mechanismofrad26assistedrescueofstalledrnapolymeraseiiintranscriptioncoupledrepair AT berniceleung mechanismofrad26assistedrescueofstalledrnapolymeraseiiintranscriptioncoupledrepair AT junxu mechanismofrad26assistedrescueofstalledrnapolymeraseiiintranscriptioncoupledrepair AT juntaekoh mechanismofrad26assistedrescueofstalledrnapolymeraseiiintranscriptioncoupledrepair AT dongwang mechanismofrad26assistedrescueofstalledrnapolymeraseiiintranscriptioncoupledrepair AT ivayloivanov mechanismofrad26assistedrescueofstalledrnapolymeraseiiintranscriptioncoupledrepair
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Mechanism of Rad26-assisted rescue of stalled RNA polymerase II in transcription-coupled repair

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