Mechanism of Rad26-assisted rescue of stalled RNA polymerase II in transcription-coupled repair

Mechanism of Rad26-assisted rescue of stalled RNA polymerase II in transcription-coupled repair

Here the authors provide models of RNA polymerase II bound to the yeast CSB ortholog Rad26 in different nucleotide states; explain how Rad26 domain motions help the polymerase progress past DNA lesions; and interpret the effects of CSB-associated disease mutations.

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Autores principales: Chunli Yan, Thomas Dodd, Jina Yu, Bernice Leung, Jun Xu, Juntaek Oh, Dong Wang, Ivaylo Ivanov
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/5e33c934a5cc481e9029a08bb4340ef4
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