M-CSF potently augments RANKL-induced resorption activation in mature human osteoclasts.

M-CSF potently augments RANKL-induced resorption activation in mature human osteoclasts.

Macrophage-CSF (M-CSF) is critical for osteoclast (OC) differentiation and is reported to enhance mature OC survival and motility. However, its role in the regulation of bone resorption, the main function of OCs, has not been well characterised. To address this we analysed short-term cultures of ful...

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Autores principales: Jason M Hodge, Fiona M Collier, Nathan J Pavlos, Mark A Kirkland, Geoffrey C Nicholson
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/5e35af53f8344c7fb260abc9b243bfd3
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