HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche

The function of high mobility group A1 (Hmga1) chromatin remodelling proteins in intestinal stem cells (ISC) is unknown. Here, the authors show that Hmga1 amplifies Wnt/β-catenin signalling to enhance self-renewal and inducesSox9to expand the Paneth cell compartment and enrich the ISC niche.

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Autores principales:	Lingling Xian, Dan Georgess, Tait Huso, Leslie Cope, Amy Belton, Yu-Ting Chang, Wenyong Kuang, Qihua Gu, Xiaoyan Zhang, Stefania Senger, Alessio Fasano, David L. Huso, Andrew J. Ewald, Linda M. S. Resar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5e3c00d6fe3d4dd9b4ee8a6610a4fe99
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spelling	oai:doaj.org-article:5e3c00d6fe3d4dd9b4ee8a6610a4fe992021-12-02T14:40:48ZHMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche10.1038/ncomms150082041-1723https://doaj.org/article/5e3c00d6fe3d4dd9b4ee8a6610a4fe992017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15008https://doaj.org/toc/2041-1723The function of high mobility group A1 (Hmga1) chromatin remodelling proteins in intestinal stem cells (ISC) is unknown. Here, the authors show that Hmga1 amplifies Wnt/β-catenin signalling to enhance self-renewal and inducesSox9to expand the Paneth cell compartment and enrich the ISC niche.Lingling XianDan GeorgessTait HusoLeslie CopeAmy BeltonYu-Ting ChangWenyong KuangQihua GuXiaoyan ZhangStefania SengerAlessio FasanoDavid L. HusoAndrew J. EwaldLinda M. S. ResarNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lingling Xian Dan Georgess Tait Huso Leslie Cope Amy Belton Yu-Ting Chang Wenyong Kuang Qihua Gu Xiaoyan Zhang Stefania Senger Alessio Fasano David L. Huso Andrew J. Ewald Linda M. S. Resar HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche
description	The function of high mobility group A1 (Hmga1) chromatin remodelling proteins in intestinal stem cells (ISC) is unknown. Here, the authors show that Hmga1 amplifies Wnt/β-catenin signalling to enhance self-renewal and inducesSox9to expand the Paneth cell compartment and enrich the ISC niche.
format	article
author	Lingling Xian Dan Georgess Tait Huso Leslie Cope Amy Belton Yu-Ting Chang Wenyong Kuang Qihua Gu Xiaoyan Zhang Stefania Senger Alessio Fasano David L. Huso Andrew J. Ewald Linda M. S. Resar
author_facet	Lingling Xian Dan Georgess Tait Huso Leslie Cope Amy Belton Yu-Ting Chang Wenyong Kuang Qihua Gu Xiaoyan Zhang Stefania Senger Alessio Fasano David L. Huso Andrew J. Ewald Linda M. S. Resar
author_sort	Lingling Xian
title	HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche
title_short	HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche
title_full	HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche
title_fullStr	HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche
title_full_unstemmed	HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche
title_sort	hmga1 amplifies wnt signalling and expands the intestinal stem cell compartment and paneth cell niche
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5e3c00d6fe3d4dd9b4ee8a6610a4fe99
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HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche

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