HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche

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HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche

The function of high mobility group A1 (Hmga1) chromatin remodelling proteins in intestinal stem cells (ISC) is unknown. Here, the authors show that Hmga1 amplifies Wnt/β-catenin signalling to enhance self-renewal and inducesSox9to expand the Paneth cell compartment and enrich the ISC niche.

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Détails bibliographiques
Auteurs principaux:	Lingling Xian, Dan Georgess, Tait Huso, Leslie Cope, Amy Belton, Yu-Ting Chang, Wenyong Kuang, Qihua Gu, Xiaoyan Zhang, Stefania Senger, Alessio Fasano, David L. Huso, Andrew J. Ewald, Linda M. S. Resar
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/5e3c00d6fe3d4dd9b4ee8a6610a4fe99
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

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