GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity

Activation of T cells in the tumor microenvironment can be inhibited through a variety of mechanisms. Here, the authors show that Rasal1, a GTPase-activating protein, binds and inhibits signaling downstream of the T Cell Receptor complex and that consistently, its reduced expression enhances anti-tu...

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Autores principales:	Youg Raj Thaker, Monika Raab, Klaus Strebhardt, Christopher E. Rudd
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5e3f7af3677d4cc6984ba9564955a165
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spelling	oai:doaj.org-article:5e3f7af3677d4cc6984ba9564955a1652021-12-02T15:36:18ZGTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity10.1038/s41467-019-12544-42041-1723https://doaj.org/article/5e3f7af3677d4cc6984ba9564955a1652019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12544-4https://doaj.org/toc/2041-1723Activation of T cells in the tumor microenvironment can be inhibited through a variety of mechanisms. Here, the authors show that Rasal1, a GTPase-activating protein, binds and inhibits signaling downstream of the T Cell Receptor complex and that consistently, its reduced expression enhances anti-tumor T-cell responses in two syngeneic cancer mouse models.Youg Raj ThakerMonika RaabKlaus StrebhardtChristopher E. RuddNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Youg Raj Thaker Monika Raab Klaus Strebhardt Christopher E. Rudd GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity
description	Activation of T cells in the tumor microenvironment can be inhibited through a variety of mechanisms. Here, the authors show that Rasal1, a GTPase-activating protein, binds and inhibits signaling downstream of the T Cell Receptor complex and that consistently, its reduced expression enhances anti-tumor T-cell responses in two syngeneic cancer mouse models.
format	article
author	Youg Raj Thaker Monika Raab Klaus Strebhardt Christopher E. Rudd
author_facet	Youg Raj Thaker Monika Raab Klaus Strebhardt Christopher E. Rudd
author_sort	Youg Raj Thaker
title	GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity
title_short	GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity
title_full	GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity
title_fullStr	GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity
title_full_unstemmed	GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity
title_sort	gtpase-activating protein rasal1 associates with zap-70 of the tcr and negatively regulates t-cell tumor immunity
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5e3f7af3677d4cc6984ba9564955a165
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GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity

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