Anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18–25 years) with corresponding changes in gut bacterial composition

Abstract Current research implicates pre- and probiotic supplementation as a potential tool for improving symptomology in physical and mental ailments, which makes it an attractive concept for clinicians and consumers alike. Here we focus on the transitional period of late adolescence and early adul...

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Autores principales:	Nicola Johnstone, Chiara Milesi, Olivia Burn, Bartholomeus van den Bogert, Arjen Nauta, Kathryn Hart, Paul Sowden, Philip W. J. Burnet, Kathrin Cohen Kadosh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5e413d2a4b894b1fb5947dd1d36f4502
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spelling	oai:doaj.org-article:5e413d2a4b894b1fb5947dd1d36f45022021-12-02T18:02:47ZAnxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18–25 years) with corresponding changes in gut bacterial composition10.1038/s41598-021-87865-w2045-2322https://doaj.org/article/5e413d2a4b894b1fb5947dd1d36f45022021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87865-whttps://doaj.org/toc/2045-2322Abstract Current research implicates pre- and probiotic supplementation as a potential tool for improving symptomology in physical and mental ailments, which makes it an attractive concept for clinicians and consumers alike. Here we focus on the transitional period of late adolescence and early adulthood during which effective interventions, such as nutritional supplementation to influence the gut microbiota, have the potential to offset health-related costs in later life. We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses. We report effects of the GOS intervention on self-reported high trait anxiety, attentional bias, and bacterial abundance, suggesting that dietary supplementation with a GOS prebiotic may improve indices of pre-clinical anxiety. Gut microbiota research has captured the imagination of the scientific and lay community alike, yet we are now at a stage where this early enthusiasm will need to be met with rigorous research in humans. Our work makes an important contribution to this effort by combining a psychobiotic intervention in a human sample with comprehensive behavioural and gut microbiota measures.Nicola JohnstoneChiara MilesiOlivia BurnBartholomeus van den BogertArjen NautaKathryn HartPaul SowdenPhilip W. J. BurnetKathrin Cohen KadoshNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nicola Johnstone Chiara Milesi Olivia Burn Bartholomeus van den Bogert Arjen Nauta Kathryn Hart Paul Sowden Philip W. J. Burnet Kathrin Cohen Kadosh Anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18–25 years) with corresponding changes in gut bacterial composition
description	Abstract Current research implicates pre- and probiotic supplementation as a potential tool for improving symptomology in physical and mental ailments, which makes it an attractive concept for clinicians and consumers alike. Here we focus on the transitional period of late adolescence and early adulthood during which effective interventions, such as nutritional supplementation to influence the gut microbiota, have the potential to offset health-related costs in later life. We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses. We report effects of the GOS intervention on self-reported high trait anxiety, attentional bias, and bacterial abundance, suggesting that dietary supplementation with a GOS prebiotic may improve indices of pre-clinical anxiety. Gut microbiota research has captured the imagination of the scientific and lay community alike, yet we are now at a stage where this early enthusiasm will need to be met with rigorous research in humans. Our work makes an important contribution to this effort by combining a psychobiotic intervention in a human sample with comprehensive behavioural and gut microbiota measures.
format	article
author	Nicola Johnstone Chiara Milesi Olivia Burn Bartholomeus van den Bogert Arjen Nauta Kathryn Hart Paul Sowden Philip W. J. Burnet Kathrin Cohen Kadosh
author_facet	Nicola Johnstone Chiara Milesi Olivia Burn Bartholomeus van den Bogert Arjen Nauta Kathryn Hart Paul Sowden Philip W. J. Burnet Kathrin Cohen Kadosh
author_sort	Nicola Johnstone
title	Anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18–25 years) with corresponding changes in gut bacterial composition
title_short	Anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18–25 years) with corresponding changes in gut bacterial composition
title_full	Anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18–25 years) with corresponding changes in gut bacterial composition
title_fullStr	Anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18–25 years) with corresponding changes in gut bacterial composition
title_full_unstemmed	Anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18–25 years) with corresponding changes in gut bacterial composition
title_sort	anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18–25 years) with corresponding changes in gut bacterial composition
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5e413d2a4b894b1fb5947dd1d36f4502
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Anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18–25 years) with corresponding changes in gut bacterial composition

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