A Comparison between the Effect of Halothane and Propofol on Liver Enzymes after General Anesthesia

BACKGROUND AND OBJECTIVE: Halothane is the most common inhalation anesthetic drug in the world and there is an increasing interest for using intravenous anesthetics like propofol. The purpose of this study was to compare the effect of halothane and propofol on hepatic enzymes after general anesthesi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	M Kashifard, E Alijanpour, M Hoseinian
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2011
Materias:	halothane propofol liver enzymes general anesthesia Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5e42798fce2a45fe92f915ddad9f71a8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5e42798fce2a45fe92f915ddad9f71a8
record_format	dspace
spelling	oai:doaj.org-article:5e42798fce2a45fe92f915ddad9f71a82021-11-10T08:56:18ZA Comparison between the Effect of Halothane and Propofol on Liver Enzymes after General Anesthesia1561-41072251-7170https://doaj.org/article/5e42798fce2a45fe92f915ddad9f71a82011-02-01T00:00:00Zhttp://jbums.org/article-1-3714-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Halothane is the most common inhalation anesthetic drug in the world and there is an increasing interest for using intravenous anesthetics like propofol. The purpose of this study was to compare the effect of halothane and propofol on hepatic enzymes after general anesthesia. METHODS: This randomized clinical trial study was performed on 58 patients (14-69 years old) classified in class I of American Society of Anesthetics. These patients who had no preliminary symptomatic hepatic, cardiac or renal disease admitted for elective surgery (ENT, eye, orthopedics, general surgery, and urology). These patients were divided randomly into two groups: 30 patients in the propofol group and 28 patients in the halothane group. In both groups, pre-medication and induction of anesthesia were the same. For the maintenance of anesthesia in the study group there was continuous infusion of propofol and for the control group, 0.5-1% halothane inhalation. From all the patients, three blood samples were taken separately prior to the anesthesia, twenty four hours and seven days after the anesthesia. These samples were tested and compared for aspartate aminotransferase (AST), alanine amino transferase (ALT), alkaline phosphates (ALP) and Billirubin (total and direct)FINDINGS: Mean anesthesia duration in propofol group was 91±14.7 minute and in halothan group was 93.2±17 minute that there was not statistically significant difference in duration of anesthesia between the two groups. Seven days after anesthesia ALP, the total and direct billirubine levels did not show significant differences between the two groups. However, AST (p=0.008) and ALT (p=0.003) increased in halothane group in compared with propofol group.CONCLUSION: The results show that propofol has less effect on liver enzymes as compared to halothane. This can be considered in anesthetic drug usage.M KashifardE AlijanpourM HoseinianBabol University of Medical Sciencesarticlehalothanepropofolliver enzymesgeneral anesthesiaMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 13, Iss 1, Pp 7-13 (2011)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	halothane propofol liver enzymes general anesthesia Medicine R Medicine (General) R5-920
spellingShingle	halothane propofol liver enzymes general anesthesia Medicine R Medicine (General) R5-920 M Kashifard E Alijanpour M Hoseinian A Comparison between the Effect of Halothane and Propofol on Liver Enzymes after General Anesthesia
description	BACKGROUND AND OBJECTIVE: Halothane is the most common inhalation anesthetic drug in the world and there is an increasing interest for using intravenous anesthetics like propofol. The purpose of this study was to compare the effect of halothane and propofol on hepatic enzymes after general anesthesia. METHODS: This randomized clinical trial study was performed on 58 patients (14-69 years old) classified in class I of American Society of Anesthetics. These patients who had no preliminary symptomatic hepatic, cardiac or renal disease admitted for elective surgery (ENT, eye, orthopedics, general surgery, and urology). These patients were divided randomly into two groups: 30 patients in the propofol group and 28 patients in the halothane group. In both groups, pre-medication and induction of anesthesia were the same. For the maintenance of anesthesia in the study group there was continuous infusion of propofol and for the control group, 0.5-1% halothane inhalation. From all the patients, three blood samples were taken separately prior to the anesthesia, twenty four hours and seven days after the anesthesia. These samples were tested and compared for aspartate aminotransferase (AST), alanine amino transferase (ALT), alkaline phosphates (ALP) and Billirubin (total and direct)FINDINGS: Mean anesthesia duration in propofol group was 91±14.7 minute and in halothan group was 93.2±17 minute that there was not statistically significant difference in duration of anesthesia between the two groups. Seven days after anesthesia ALP, the total and direct billirubine levels did not show significant differences between the two groups. However, AST (p=0.008) and ALT (p=0.003) increased in halothane group in compared with propofol group.CONCLUSION: The results show that propofol has less effect on liver enzymes as compared to halothane. This can be considered in anesthetic drug usage.
format	article
author	M Kashifard E Alijanpour M Hoseinian
author_facet	M Kashifard E Alijanpour M Hoseinian
author_sort	M Kashifard
title	A Comparison between the Effect of Halothane and Propofol on Liver Enzymes after General Anesthesia
title_short	A Comparison between the Effect of Halothane and Propofol on Liver Enzymes after General Anesthesia
title_full	A Comparison between the Effect of Halothane and Propofol on Liver Enzymes after General Anesthesia
title_fullStr	A Comparison between the Effect of Halothane and Propofol on Liver Enzymes after General Anesthesia
title_full_unstemmed	A Comparison between the Effect of Halothane and Propofol on Liver Enzymes after General Anesthesia
title_sort	comparison between the effect of halothane and propofol on liver enzymes after general anesthesia
publisher	Babol University of Medical Sciences
publishDate	2011
url	https://doaj.org/article/5e42798fce2a45fe92f915ddad9f71a8
work_keys_str_mv	AT mkashifard acomparisonbetweentheeffectofhalothaneandpropofolonliverenzymesaftergeneralanesthesia AT ealijanpour acomparisonbetweentheeffectofhalothaneandpropofolonliverenzymesaftergeneralanesthesia AT mhoseinian acomparisonbetweentheeffectofhalothaneandpropofolonliverenzymesaftergeneralanesthesia AT mkashifard comparisonbetweentheeffectofhalothaneandpropofolonliverenzymesaftergeneralanesthesia AT ealijanpour comparisonbetweentheeffectofhalothaneandpropofolonliverenzymesaftergeneralanesthesia AT mhoseinian comparisonbetweentheeffectofhalothaneandpropofolonliverenzymesaftergeneralanesthesia
_version_	1718440375849320448

A Comparison between the Effect of Halothane and Propofol on Liver Enzymes after General Anesthesia

Ejemplares similares