Recurrent activating mutations of PPARγ associated with luminal bladder tumors
Activation of the PPARγ/RXRα pathway in luminal bladder cancers has mainly been linked to PPARG gene amplifications and activating point mutations in RXRα. Here, the authors identify recurrent PPARγ mutations with similar effects and elucidate the structural basis for this mutational PPARγ activatio...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/5e44a383003c4ce0b87b4a701664d7c3 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:5e44a383003c4ce0b87b4a701664d7c3 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:5e44a383003c4ce0b87b4a701664d7c32021-12-02T17:01:53ZRecurrent activating mutations of PPARγ associated with luminal bladder tumors10.1038/s41467-018-08157-y2041-1723https://doaj.org/article/5e44a383003c4ce0b87b4a701664d7c32019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08157-yhttps://doaj.org/toc/2041-1723Activation of the PPARγ/RXRα pathway in luminal bladder cancers has mainly been linked to PPARG gene amplifications and activating point mutations in RXRα. Here, the authors identify recurrent PPARγ mutations with similar effects and elucidate the structural basis for this mutational PPARγ activation.Natacha RochelClémentine KruckerLaure Coutos-ThévenotJudit OszRuiyun ZhangElodie GuyonWayne ZitaSéverin VanthongOscar Alba HernandezMaxime BourguetKays Al BadawyFlorent DufourCarole Peluso-IltisSyrine Heckler-BejiAnnick DejaegereAurélie KamounAurélien de ReynièsYann NeuzilletSandra RebouissouClaire BéraudHervé LangThierry MassfelderYves AllorySarah CianféraniRoland H. StoteFrançois RadvanyiIsabelle Bernard-PierrotNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Natacha Rochel Clémentine Krucker Laure Coutos-Thévenot Judit Osz Ruiyun Zhang Elodie Guyon Wayne Zita Séverin Vanthong Oscar Alba Hernandez Maxime Bourguet Kays Al Badawy Florent Dufour Carole Peluso-Iltis Syrine Heckler-Beji Annick Dejaegere Aurélie Kamoun Aurélien de Reyniès Yann Neuzillet Sandra Rebouissou Claire Béraud Hervé Lang Thierry Massfelder Yves Allory Sarah Cianférani Roland H. Stote François Radvanyi Isabelle Bernard-Pierrot Recurrent activating mutations of PPARγ associated with luminal bladder tumors |
| description |
Activation of the PPARγ/RXRα pathway in luminal bladder cancers has mainly been linked to PPARG gene amplifications and activating point mutations in RXRα. Here, the authors identify recurrent PPARγ mutations with similar effects and elucidate the structural basis for this mutational PPARγ activation. |
| format |
article |
| author |
Natacha Rochel Clémentine Krucker Laure Coutos-Thévenot Judit Osz Ruiyun Zhang Elodie Guyon Wayne Zita Séverin Vanthong Oscar Alba Hernandez Maxime Bourguet Kays Al Badawy Florent Dufour Carole Peluso-Iltis Syrine Heckler-Beji Annick Dejaegere Aurélie Kamoun Aurélien de Reyniès Yann Neuzillet Sandra Rebouissou Claire Béraud Hervé Lang Thierry Massfelder Yves Allory Sarah Cianférani Roland H. Stote François Radvanyi Isabelle Bernard-Pierrot |
| author_facet |
Natacha Rochel Clémentine Krucker Laure Coutos-Thévenot Judit Osz Ruiyun Zhang Elodie Guyon Wayne Zita Séverin Vanthong Oscar Alba Hernandez Maxime Bourguet Kays Al Badawy Florent Dufour Carole Peluso-Iltis Syrine Heckler-Beji Annick Dejaegere Aurélie Kamoun Aurélien de Reyniès Yann Neuzillet Sandra Rebouissou Claire Béraud Hervé Lang Thierry Massfelder Yves Allory Sarah Cianférani Roland H. Stote François Radvanyi Isabelle Bernard-Pierrot |
| author_sort |
Natacha Rochel |
| title |
Recurrent activating mutations of PPARγ associated with luminal bladder tumors |
| title_short |
Recurrent activating mutations of PPARγ associated with luminal bladder tumors |
| title_full |
Recurrent activating mutations of PPARγ associated with luminal bladder tumors |
| title_fullStr |
Recurrent activating mutations of PPARγ associated with luminal bladder tumors |
| title_full_unstemmed |
Recurrent activating mutations of PPARγ associated with luminal bladder tumors |
| title_sort |
recurrent activating mutations of pparγ associated with luminal bladder tumors |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/5e44a383003c4ce0b87b4a701664d7c3 |
| work_keys_str_mv |
AT natacharochel recurrentactivatingmutationsofppargassociatedwithluminalbladdertumors AT clementinekrucker recurrentactivatingmutationsofppargassociatedwithluminalbladdertumors AT laurecoutosthevenot recurrentactivatingmutationsofppargassociatedwithluminalbladdertumors AT juditosz recurrentactivatingmutationsofppargassociatedwithluminalbladdertumors AT ruiyunzhang recurrentactivatingmutationsofppargassociatedwithluminalbladdertumors AT elodieguyon recurrentactivatingmutationsofppargassociatedwithluminalbladdertumors AT waynezita recurrentactivatingmutationsofppargassociatedwithluminalbladdertumors AT severinvanthong recurrentactivatingmutationsofppargassociatedwithluminalbladdertumors AT oscaralbahernandez recurrentactivatingmutationsofppargassociatedwithluminalbladdertumors AT maximebourguet recurrentactivatingmutationsofppargassociatedwithluminalbladdertumors AT kaysalbadawy recurrentactivatingmutationsofppargassociatedwithluminalbladdertumors AT florentdufour recurrentactivatingmutationsofppargassociatedwithluminalbladdertumors AT carolepelusoiltis recurrentactivatingmutationsofppargassociatedwithluminalbladdertumors AT syrinehecklerbeji recurrentactivatingmutationsofppargassociatedwithluminalbladdertumors AT annickdejaegere recurrentactivatingmutationsofppargassociatedwithluminalbladdertumors AT aureliekamoun recurrentactivatingmutationsofppargassociatedwithluminalbladdertumors AT aureliendereynies recurrentactivatingmutationsofppargassociatedwithluminalbladdertumors AT yannneuzillet recurrentactivatingmutationsofppargassociatedwithluminalbladdertumors AT sandrarebouissou recurrentactivatingmutationsofppargassociatedwithluminalbladdertumors AT claireberaud recurrentactivatingmutationsofppargassociatedwithluminalbladdertumors AT hervelang recurrentactivatingmutationsofppargassociatedwithluminalbladdertumors AT thierrymassfelder recurrentactivatingmutationsofppargassociatedwithluminalbladdertumors AT yvesallory recurrentactivatingmutationsofppargassociatedwithluminalbladdertumors AT sarahcianferani recurrentactivatingmutationsofppargassociatedwithluminalbladdertumors AT rolandhstote recurrentactivatingmutationsofppargassociatedwithluminalbladdertumors AT francoisradvanyi recurrentactivatingmutationsofppargassociatedwithluminalbladdertumors AT isabellebernardpierrot recurrentactivatingmutationsofppargassociatedwithluminalbladdertumors |
| _version_ |
1718382031020228608 |