Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway

Abstract Rosmarinic acid (RA), a polyphenol found in Lamiaceae herbs, is a candidate of preventive ingredients against Alzheimer’s disease (AD) as it potently suppresses the aggregation of amyloid β (Aβ); however, the effect of RA on tau phosphorylation and cognitive dysfunction remains unclear. The...

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Autores principales:	So Yamamoto, Tomoko Kayama, Moeko Noguchi-Shinohara, Tsuyoshi Hamaguchi, Masahito Yamada, Keiko Abe, Shoko Kobayashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Nutrition. Foods and food supply TX341-641 Food processing and manufacture TP368-456
Acceso en línea:	https://doaj.org/article/5e455a803e4e47eca76785f5f73fcc6e
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spelling	oai:doaj.org-article:5e455a803e4e47eca76785f5f73fcc6e2021-12-02T10:48:01ZRosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway10.1038/s41538-021-00084-52396-8370https://doaj.org/article/5e455a803e4e47eca76785f5f73fcc6e2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41538-021-00084-5https://doaj.org/toc/2396-8370Abstract Rosmarinic acid (RA), a polyphenol found in Lamiaceae herbs, is a candidate of preventive ingredients against Alzheimer’s disease (AD) as it potently suppresses the aggregation of amyloid β (Aβ); however, the effect of RA on tau phosphorylation and cognitive dysfunction remains unclear. The present study revealed that RA intake inhibited the pathological hallmarks of AD, including Aβ and phosphorylated tau accumulation, and improved cognitive function in the 3 × Tg-AD mouse model. Additionally, RA intake suppressed hippocampal inflammation and led to the downregulation of the JNK signaling pathway that induces tau phosphorylation. Feeding with RA exerted an anti-inflammatory effect not only in the central nervous system but also in the periphery. Downregulation of the JNK signaling pathway in hippocampus may be a potential mechanism underlying the inhibition of progression of pathology and cognitive deficit by RA feeding.So YamamotoTomoko KayamaMoeko Noguchi-ShinoharaTsuyoshi HamaguchiMasahito YamadaKeiko AbeShoko KobayashiNature PortfolioarticleNutrition. Foods and food supplyTX341-641Food processing and manufactureTP368-456ENnpj Science of Food, Vol 5, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nutrition. Foods and food supply TX341-641 Food processing and manufacture TP368-456
spellingShingle	Nutrition. Foods and food supply TX341-641 Food processing and manufacture TP368-456 So Yamamoto Tomoko Kayama Moeko Noguchi-Shinohara Tsuyoshi Hamaguchi Masahito Yamada Keiko Abe Shoko Kobayashi Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway
description	Abstract Rosmarinic acid (RA), a polyphenol found in Lamiaceae herbs, is a candidate of preventive ingredients against Alzheimer’s disease (AD) as it potently suppresses the aggregation of amyloid β (Aβ); however, the effect of RA on tau phosphorylation and cognitive dysfunction remains unclear. The present study revealed that RA intake inhibited the pathological hallmarks of AD, including Aβ and phosphorylated tau accumulation, and improved cognitive function in the 3 × Tg-AD mouse model. Additionally, RA intake suppressed hippocampal inflammation and led to the downregulation of the JNK signaling pathway that induces tau phosphorylation. Feeding with RA exerted an anti-inflammatory effect not only in the central nervous system but also in the periphery. Downregulation of the JNK signaling pathway in hippocampus may be a potential mechanism underlying the inhibition of progression of pathology and cognitive deficit by RA feeding.
format	article
author	So Yamamoto Tomoko Kayama Moeko Noguchi-Shinohara Tsuyoshi Hamaguchi Masahito Yamada Keiko Abe Shoko Kobayashi
author_facet	So Yamamoto Tomoko Kayama Moeko Noguchi-Shinohara Tsuyoshi Hamaguchi Masahito Yamada Keiko Abe Shoko Kobayashi
author_sort	So Yamamoto
title	Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway
title_short	Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway
title_full	Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway
title_fullStr	Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway
title_full_unstemmed	Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway
title_sort	rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the jnk signaling pathway
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5e455a803e4e47eca76785f5f73fcc6e
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Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway

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