Predictors of Anemia Among Adult HIV Positive Patients on First-Line Antiretroviral Therapy in Northwest Ethiopia: A Retrospective Follow-Up Study

Chilot Desta Agegnehu,1 Mehari Woldemariam Merid,2 Melaku Kindie Yenit2 1School of Nursing, College of Medicine and Health Sciences and Comprehensive Specialized Hospital, University of Gondar, Gondar, Ethiopia; 2Department of Epidemiology and Biostatistics, Institute of Public Health, College of Me...

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Autores principales:	Agegnehu CD, Merid MW, Yenit MK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	anemia incidence hiv first-line haart ethiopia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/5e46734451cb412f8e164234dcd59b20
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spelling	oai:doaj.org-article:5e46734451cb412f8e164234dcd59b202021-12-02T16:54:19ZPredictors of Anemia Among Adult HIV Positive Patients on First-Line Antiretroviral Therapy in Northwest Ethiopia: A Retrospective Follow-Up Study1179-1373https://doaj.org/article/5e46734451cb412f8e164234dcd59b202021-04-01T00:00:00Zhttps://www.dovepress.com/predictors-of-anemia-among-adult-hiv-positive-patients-on-first-line-a-peer-reviewed-fulltext-article-HIVhttps://doaj.org/toc/1179-1373Chilot Desta Agegnehu,1 Mehari Woldemariam Merid,2 Melaku Kindie Yenit2 1School of Nursing, College of Medicine and Health Sciences and Comprehensive Specialized Hospital, University of Gondar, Gondar, Ethiopia; 2Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Chilot Desta AgegnehuSchool of Nursing, College of Medicine and Health Sciences and Comprehensive Specialized Hospital, University of Gondar, P.O. Box: 196, Gondar, EthiopiaTel +251 9-18-62-74-03Email chilotdesta@gmail.comBackground: Globally, anemia is a common hematological disorder among HIV-infected patients. People with anemia often suffer from impaired physical functioning, psychological distress, and poor quality of life. Therefore, the aim of this study was to determine the incidence of anemia and its determinants among HIV positive individuals in northwest Ethiopia.Methods: A total of 486 adult HIV positive patients on the first-line ART with complete information were enrolled in the adult care clinics of northwest Amhara referral hospitals from December 2015 to December 2018. EpiData version 4.2 was used for data entry and Stata version 14 for analysis. Variables having time to event nature were presented with the Kaplan–Meier function. The Cox regression model was used to identify predictors of anemia. Variables with P-values less than 0.2 in the bivariable analysis were considered in the multivariable regression. Adjusted hazard ratio with 95% CI was computed, and variables with less than 0.05 P-values in the multivariable Cox regression were taken as significant predictors of anemia.Results: This study noted an overall 26.4 per 100 person-year observations (95% CI: 23.46, 30.74) incidence rate of anemia. According to the multivariable Cox regression, TB co-infection (AHR =1.99, 95% CI: 1.45, 2.74), zidovudine-based regimen (AHR=1.39, 95CI: 1.1, 1.85), CD4 level (AHR= 1.7, 95% CI: 1.23, 2.35), advanced WHO stage (AHR=1.32, 95% CI: 1.01, 1.74), and being underweight (AHR= 1.53, 95% CI: 1.14, 2.07) were predictors of anemia.Conclusion: Anemia is a burden among HIV patients in the study setting. Baseline clinical variables, TB co-infection, and zidovudine-based were predictors of anemia. Therefore, early identification of anemia and addressing significant predictors are highly suggested to the study setting.Keywords: anemia incidence, HIV, first-line HAART, EthiopiaAgegnehu CDMerid MWYenit MKDove Medical Pressarticleanemia incidencehivfirst-line haartethiopiaImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 13, Pp 455-466 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anemia incidence hiv first-line haart ethiopia Immunologic diseases. Allergy RC581-607
spellingShingle	anemia incidence hiv first-line haart ethiopia Immunologic diseases. Allergy RC581-607 Agegnehu CD Merid MW Yenit MK Predictors of Anemia Among Adult HIV Positive Patients on First-Line Antiretroviral Therapy in Northwest Ethiopia: A Retrospective Follow-Up Study
description	Chilot Desta Agegnehu,1 Mehari Woldemariam Merid,2 Melaku Kindie Yenit2 1School of Nursing, College of Medicine and Health Sciences and Comprehensive Specialized Hospital, University of Gondar, Gondar, Ethiopia; 2Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Chilot Desta AgegnehuSchool of Nursing, College of Medicine and Health Sciences and Comprehensive Specialized Hospital, University of Gondar, P.O. Box: 196, Gondar, EthiopiaTel +251 9-18-62-74-03Email chilotdesta@gmail.comBackground: Globally, anemia is a common hematological disorder among HIV-infected patients. People with anemia often suffer from impaired physical functioning, psychological distress, and poor quality of life. Therefore, the aim of this study was to determine the incidence of anemia and its determinants among HIV positive individuals in northwest Ethiopia.Methods: A total of 486 adult HIV positive patients on the first-line ART with complete information were enrolled in the adult care clinics of northwest Amhara referral hospitals from December 2015 to December 2018. EpiData version 4.2 was used for data entry and Stata version 14 for analysis. Variables having time to event nature were presented with the Kaplan–Meier function. The Cox regression model was used to identify predictors of anemia. Variables with P-values less than 0.2 in the bivariable analysis were considered in the multivariable regression. Adjusted hazard ratio with 95% CI was computed, and variables with less than 0.05 P-values in the multivariable Cox regression were taken as significant predictors of anemia.Results: This study noted an overall 26.4 per 100 person-year observations (95% CI: 23.46, 30.74) incidence rate of anemia. According to the multivariable Cox regression, TB co-infection (AHR =1.99, 95% CI: 1.45, 2.74), zidovudine-based regimen (AHR=1.39, 95CI: 1.1, 1.85), CD4 level (AHR= 1.7, 95% CI: 1.23, 2.35), advanced WHO stage (AHR=1.32, 95% CI: 1.01, 1.74), and being underweight (AHR= 1.53, 95% CI: 1.14, 2.07) were predictors of anemia.Conclusion: Anemia is a burden among HIV patients in the study setting. Baseline clinical variables, TB co-infection, and zidovudine-based were predictors of anemia. Therefore, early identification of anemia and addressing significant predictors are highly suggested to the study setting.Keywords: anemia incidence, HIV, first-line HAART, Ethiopia
format	article
author	Agegnehu CD Merid MW Yenit MK
author_facet	Agegnehu CD Merid MW Yenit MK
author_sort	Agegnehu CD
title	Predictors of Anemia Among Adult HIV Positive Patients on First-Line Antiretroviral Therapy in Northwest Ethiopia: A Retrospective Follow-Up Study
title_short	Predictors of Anemia Among Adult HIV Positive Patients on First-Line Antiretroviral Therapy in Northwest Ethiopia: A Retrospective Follow-Up Study
title_full	Predictors of Anemia Among Adult HIV Positive Patients on First-Line Antiretroviral Therapy in Northwest Ethiopia: A Retrospective Follow-Up Study
title_fullStr	Predictors of Anemia Among Adult HIV Positive Patients on First-Line Antiretroviral Therapy in Northwest Ethiopia: A Retrospective Follow-Up Study
title_full_unstemmed	Predictors of Anemia Among Adult HIV Positive Patients on First-Line Antiretroviral Therapy in Northwest Ethiopia: A Retrospective Follow-Up Study
title_sort	predictors of anemia among adult hiv positive patients on first-line antiretroviral therapy in northwest ethiopia: a retrospective follow-up study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/5e46734451cb412f8e164234dcd59b20
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Predictors of Anemia Among Adult HIV Positive Patients on First-Line Antiretroviral Therapy in Northwest Ethiopia: A Retrospective Follow-Up Study

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