Effects of stent generation on clinical outcomes after acute myocardial infarction compared between prediabetes and diabetes patients

Abstract We investigated the effects of stent generation on 2-year clinical outcomes between prediabetes and diabetes patients after acute myocardial infarction (AMI). A total of 13,895 AMI patients were classified into normoglycemia (group A: 3673), prediabetes (group B: 5205), and diabetes (group...

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Autores principales:	Yong Hoon Kim, Ae-Young Her, Myung Ho Jeong, Byeong-Keuk Kim, Sung-Jin Hong, Seunghwan Kim, Chul-Min Ahn, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5e470ac56bc54f8486b3d408ce566b40
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spelling	oai:doaj.org-article:5e470ac56bc54f8486b3d408ce566b402021-12-02T16:55:24ZEffects of stent generation on clinical outcomes after acute myocardial infarction compared between prediabetes and diabetes patients10.1038/s41598-021-88593-x2045-2322https://doaj.org/article/5e470ac56bc54f8486b3d408ce566b402021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88593-xhttps://doaj.org/toc/2045-2322Abstract We investigated the effects of stent generation on 2-year clinical outcomes between prediabetes and diabetes patients after acute myocardial infarction (AMI). A total of 13,895 AMI patients were classified into normoglycemia (group A: 3673), prediabetes (group B: 5205), and diabetes (group C: 5017). Thereafter, all three groups were further divided into first-generation (1G)-drug-eluting stent (DES) and second-generation (2G)-DES groups. Patient-oriented composite outcomes (POCOs) defined as all-cause death, recurrent myocardial infarction (Re-MI), and any repeat revascularization were the primary outcome. Stent thrombosis (ST) was the secondary outcome. In both prediabetes and diabetes groups, the cumulative incidences of POCOs, any repeat revascularization, and ST were higher in the 1G-DES than that in the 2G-DES. In the diabetes group, all-cause death and cardiac death rates were higher in the 1G-DES than that in the 2G-DES. In both stent generations, the cumulative incidence of POCOs was similar between the prediabetes and diabetes groups. However, in the 2G-DES group, the cumulative incidences of Re-MI and all-cause death or MI were significantly higher in the diabetes group than that in the prediabetes group. To conclude, 2G-DES was more effective than 1G-DES in reducing the primary and secondary outcomes for both prediabetes and diabetes groups.Yong Hoon KimAe-Young HerMyung Ho JeongByeong-Keuk KimSung-Jin HongSeunghwan KimChul-Min AhnJung-Sun KimYoung-Guk KoDonghoon ChoiMyeong-Ki HongYangsoo JangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yong Hoon Kim Ae-Young Her Myung Ho Jeong Byeong-Keuk Kim Sung-Jin Hong Seunghwan Kim Chul-Min Ahn Jung-Sun Kim Young-Guk Ko Donghoon Choi Myeong-Ki Hong Yangsoo Jang Effects of stent generation on clinical outcomes after acute myocardial infarction compared between prediabetes and diabetes patients
description	Abstract We investigated the effects of stent generation on 2-year clinical outcomes between prediabetes and diabetes patients after acute myocardial infarction (AMI). A total of 13,895 AMI patients were classified into normoglycemia (group A: 3673), prediabetes (group B: 5205), and diabetes (group C: 5017). Thereafter, all three groups were further divided into first-generation (1G)-drug-eluting stent (DES) and second-generation (2G)-DES groups. Patient-oriented composite outcomes (POCOs) defined as all-cause death, recurrent myocardial infarction (Re-MI), and any repeat revascularization were the primary outcome. Stent thrombosis (ST) was the secondary outcome. In both prediabetes and diabetes groups, the cumulative incidences of POCOs, any repeat revascularization, and ST were higher in the 1G-DES than that in the 2G-DES. In the diabetes group, all-cause death and cardiac death rates were higher in the 1G-DES than that in the 2G-DES. In both stent generations, the cumulative incidence of POCOs was similar between the prediabetes and diabetes groups. However, in the 2G-DES group, the cumulative incidences of Re-MI and all-cause death or MI were significantly higher in the diabetes group than that in the prediabetes group. To conclude, 2G-DES was more effective than 1G-DES in reducing the primary and secondary outcomes for both prediabetes and diabetes groups.
format	article
author	Yong Hoon Kim Ae-Young Her Myung Ho Jeong Byeong-Keuk Kim Sung-Jin Hong Seunghwan Kim Chul-Min Ahn Jung-Sun Kim Young-Guk Ko Donghoon Choi Myeong-Ki Hong Yangsoo Jang
author_facet	Yong Hoon Kim Ae-Young Her Myung Ho Jeong Byeong-Keuk Kim Sung-Jin Hong Seunghwan Kim Chul-Min Ahn Jung-Sun Kim Young-Guk Ko Donghoon Choi Myeong-Ki Hong Yangsoo Jang
author_sort	Yong Hoon Kim
title	Effects of stent generation on clinical outcomes after acute myocardial infarction compared between prediabetes and diabetes patients
title_short	Effects of stent generation on clinical outcomes after acute myocardial infarction compared between prediabetes and diabetes patients
title_full	Effects of stent generation on clinical outcomes after acute myocardial infarction compared between prediabetes and diabetes patients
title_fullStr	Effects of stent generation on clinical outcomes after acute myocardial infarction compared between prediabetes and diabetes patients
title_full_unstemmed	Effects of stent generation on clinical outcomes after acute myocardial infarction compared between prediabetes and diabetes patients
title_sort	effects of stent generation on clinical outcomes after acute myocardial infarction compared between prediabetes and diabetes patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5e470ac56bc54f8486b3d408ce566b40
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Effects of stent generation on clinical outcomes after acute myocardial infarction compared between prediabetes and diabetes patients

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