Acarbose promotes remission of both early and late dumping syndromes in post-bariatric patients

Flavio A Cadegiani,1 Osvalmir Sá Silva2 1Division of Endocrinology and Metabolism, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, 2Corpometria Institute, an Obesity and Endocrinology Center, Brasilia, DF, Brazil...

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Autores principales:	Cadegiani FA, Silva OS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Dumping Syndrome Bariatric Surgery Post-bariatric Obesity Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/5e483b0d35a044b0860d7968be7d559f
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spelling	oai:doaj.org-article:5e483b0d35a044b0860d7968be7d559f2021-12-02T01:07:19ZAcarbose promotes remission of both early and late dumping syndromes in post-bariatric patients1178-7007https://doaj.org/article/5e483b0d35a044b0860d7968be7d559f2016-12-01T00:00:00Zhttps://www.dovepress.com/acarbose-promotes-remission-of-both-early-and-late-dumping-syndromes-i-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Flavio A Cadegiani,1 Osvalmir Sá Silva2 1Division of Endocrinology and Metabolism, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, 2Corpometria Institute, an Obesity and Endocrinology Center, Brasilia, DF, Brazil Objective: Acarbose is a glucosidase inhibitor that slows carbohydrate digestion. It could thus be effective to promote remission of dumping syndrome (DS). Previous studies associating acarbose and late dumping, although not early dumping, have been reported. Herein, we aimed to evaluate the role of acarbose in dumping syndrome prevention and treatment and in resistive exercises resistance in bariatric subjects. Methods: Bariatric patients with DS and complete adherence to diet plan and resistive exercises were included (n=25). Number of early and late episodes, self-referred intensity of each episode, and ability to increase intensity of resistive exercise were evaluated, on a 0–10 scale. Acarbose was administered orally (50 mg) for 6 months, 4–5 times a day before meals. Results: Acarbose administration was associated with a decrease in the number of early (2.18–0.31) and late (2.79–0.12) episodes per week and intensity of each episode (6.10–1.65) and an increase in the ability to perform resistive exercises (3.03–7.12). Complete remission of DS was seen in 21 patients (84%), which persisted for 6 months with the use of acarbose. Conclusion: Acarbose prevented dumping in almost all studied subjects and helped improve exercise capacity. Keywords: dumping syndrome, bariatric surgery, post-bariatric, obesityCadegiani FASilva OSDove Medical PressarticleDumping SyndromeBariatric SurgeryPost-bariatricObesitySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 9, Pp 443-446 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dumping Syndrome Bariatric Surgery Post-bariatric Obesity Specialties of internal medicine RC581-951
spellingShingle	Dumping Syndrome Bariatric Surgery Post-bariatric Obesity Specialties of internal medicine RC581-951 Cadegiani FA Silva OS Acarbose promotes remission of both early and late dumping syndromes in post-bariatric patients
description	Flavio A Cadegiani,1 Osvalmir Sá Silva2 1Division of Endocrinology and Metabolism, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, 2Corpometria Institute, an Obesity and Endocrinology Center, Brasilia, DF, Brazil Objective: Acarbose is a glucosidase inhibitor that slows carbohydrate digestion. It could thus be effective to promote remission of dumping syndrome (DS). Previous studies associating acarbose and late dumping, although not early dumping, have been reported. Herein, we aimed to evaluate the role of acarbose in dumping syndrome prevention and treatment and in resistive exercises resistance in bariatric subjects. Methods: Bariatric patients with DS and complete adherence to diet plan and resistive exercises were included (n=25). Number of early and late episodes, self-referred intensity of each episode, and ability to increase intensity of resistive exercise were evaluated, on a 0–10 scale. Acarbose was administered orally (50 mg) for 6 months, 4–5 times a day before meals. Results: Acarbose administration was associated with a decrease in the number of early (2.18–0.31) and late (2.79–0.12) episodes per week and intensity of each episode (6.10–1.65) and an increase in the ability to perform resistive exercises (3.03–7.12). Complete remission of DS was seen in 21 patients (84%), which persisted for 6 months with the use of acarbose. Conclusion: Acarbose prevented dumping in almost all studied subjects and helped improve exercise capacity. Keywords: dumping syndrome, bariatric surgery, post-bariatric, obesity
format	article
author	Cadegiani FA Silva OS
author_facet	Cadegiani FA Silva OS
author_sort	Cadegiani FA
title	Acarbose promotes remission of both early and late dumping syndromes in post-bariatric patients
title_short	Acarbose promotes remission of both early and late dumping syndromes in post-bariatric patients
title_full	Acarbose promotes remission of both early and late dumping syndromes in post-bariatric patients
title_fullStr	Acarbose promotes remission of both early and late dumping syndromes in post-bariatric patients
title_full_unstemmed	Acarbose promotes remission of both early and late dumping syndromes in post-bariatric patients
title_sort	acarbose promotes remission of both early and late dumping syndromes in post-bariatric patients
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/5e483b0d35a044b0860d7968be7d559f
work_keys_str_mv	AT cadegianifa acarbosepromotesremissionofbothearlyandlatedumpingsyndromesinpostbariatricpatients AT silvaos acarbosepromotesremissionofbothearlyandlatedumpingsyndromesinpostbariatricpatients
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Acarbose promotes remission of both early and late dumping syndromes in post-bariatric patients

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