Bioactivity of Dietary Polyphenols: The Role in LDL-C Lowering

Cardiovascular diseases are the leading causes of the death around the world. An elevation of the low-density lipoprotein cholesterol (LDL-C) level is one of the most important risk factors for cardiovascular diseases. To achieve optimal plasma LDL-C levels, clinal therapies were investigated which...

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Autores principales:	Peng Sun, Liang Zhao, Nanhai Zhang, Jingxuan Zhou, Liebing Zhang, Wei Wu, Baoping Ji, Feng Zhou
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cardiovascular diseases LDL-C metabolism pathways dietary polyphenols Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/5e49a006ec4e453ea123a6aae504e8dd
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spelling	oai:doaj.org-article:5e49a006ec4e453ea123a6aae504e8dd2021-11-25T17:33:57ZBioactivity of Dietary Polyphenols: The Role in LDL-C Lowering10.3390/foods101126662304-8158https://doaj.org/article/5e49a006ec4e453ea123a6aae504e8dd2021-11-01T00:00:00Zhttps://www.mdpi.com/2304-8158/10/11/2666https://doaj.org/toc/2304-8158Cardiovascular diseases are the leading causes of the death around the world. An elevation of the low-density lipoprotein cholesterol (LDL-C) level is one of the most important risk factors for cardiovascular diseases. To achieve optimal plasma LDL-C levels, clinal therapies were investigated which targeted different metabolism pathways. However, some therapies also caused various adverse effects. Thus, there is a need for new treatment options and/or combination therapies to inhibit the LDL-C level. Dietary polyphenols have received much attention in the prevention of cardiovascular diseases due to their potential LDL-C lowering effects. However, the effectiveness and potential mechanisms of polyphenols in lowering LDL-C is not comprehensively summarized. This review focused on dietary polyphenols that could reduce LDL-C and their mechanisms of action. This review also discussed the limitations and suggestions regarding previous studies.Peng SunLiang ZhaoNanhai ZhangJingxuan ZhouLiebing ZhangWei WuBaoping JiFeng ZhouMDPI AGarticlecardiovascular diseasesLDL-Cmetabolism pathwaysdietary polyphenolsChemical technologyTP1-1185ENFoods, Vol 10, Iss 2666, p 2666 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiovascular diseases LDL-C metabolism pathways dietary polyphenols Chemical technology TP1-1185
spellingShingle	cardiovascular diseases LDL-C metabolism pathways dietary polyphenols Chemical technology TP1-1185 Peng Sun Liang Zhao Nanhai Zhang Jingxuan Zhou Liebing Zhang Wei Wu Baoping Ji Feng Zhou Bioactivity of Dietary Polyphenols: The Role in LDL-C Lowering
description	Cardiovascular diseases are the leading causes of the death around the world. An elevation of the low-density lipoprotein cholesterol (LDL-C) level is one of the most important risk factors for cardiovascular diseases. To achieve optimal plasma LDL-C levels, clinal therapies were investigated which targeted different metabolism pathways. However, some therapies also caused various adverse effects. Thus, there is a need for new treatment options and/or combination therapies to inhibit the LDL-C level. Dietary polyphenols have received much attention in the prevention of cardiovascular diseases due to their potential LDL-C lowering effects. However, the effectiveness and potential mechanisms of polyphenols in lowering LDL-C is not comprehensively summarized. This review focused on dietary polyphenols that could reduce LDL-C and their mechanisms of action. This review also discussed the limitations and suggestions regarding previous studies.
format	article
author	Peng Sun Liang Zhao Nanhai Zhang Jingxuan Zhou Liebing Zhang Wei Wu Baoping Ji Feng Zhou
author_facet	Peng Sun Liang Zhao Nanhai Zhang Jingxuan Zhou Liebing Zhang Wei Wu Baoping Ji Feng Zhou
author_sort	Peng Sun
title	Bioactivity of Dietary Polyphenols: The Role in LDL-C Lowering
title_short	Bioactivity of Dietary Polyphenols: The Role in LDL-C Lowering
title_full	Bioactivity of Dietary Polyphenols: The Role in LDL-C Lowering
title_fullStr	Bioactivity of Dietary Polyphenols: The Role in LDL-C Lowering
title_full_unstemmed	Bioactivity of Dietary Polyphenols: The Role in LDL-C Lowering
title_sort	bioactivity of dietary polyphenols: the role in ldl-c lowering
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5e49a006ec4e453ea123a6aae504e8dd
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Bioactivity of Dietary Polyphenols: The Role in LDL-C Lowering

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