Development of a penem antibiotic against Mycobacteroides abscessus

Batchelder et al. report a new penem class antibiotic, T405, which exhibits potent activity against M. abscessus and clinical isolates from cystic fibrosis patients. The development of resistance to T405 is inhibited with the addition of a β-lactamase inhibitor, avibactam. Its clinical potential is...

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Autores principales:	Hunter R. Batchelder, Elizabeth Story-Roller, Evan P. Lloyd, Amit Kaushik, Kristina M. Bigelow, Emily C. Maggioncalda, Eric L. Nuermberger, Gyanu Lamichhane, Craig A. Townsend
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5e507dd0a49447c7b96b6dc7becd6906
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spelling	oai:doaj.org-article:5e507dd0a49447c7b96b6dc7becd69062021-12-02T15:18:51ZDevelopment of a penem antibiotic against Mycobacteroides abscessus10.1038/s42003-020-01475-22399-3642https://doaj.org/article/5e507dd0a49447c7b96b6dc7becd69062020-12-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01475-2https://doaj.org/toc/2399-3642Batchelder et al. report a new penem class antibiotic, T405, which exhibits potent activity against M. abscessus and clinical isolates from cystic fibrosis patients. The development of resistance to T405 is inhibited with the addition of a β-lactamase inhibitor, avibactam. Its clinical potential is further demonstrated by T405 displaying a favourable pharmacokinetic profile in mice with an absence of toxicity.Hunter R. BatchelderElizabeth Story-RollerEvan P. LloydAmit KaushikKristina M. BigelowEmily C. MaggioncaldaEric L. NuermbergerGyanu LamichhaneCraig A. TownsendNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 3, Iss 1, Pp 1-5 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Hunter R. Batchelder Elizabeth Story-Roller Evan P. Lloyd Amit Kaushik Kristina M. Bigelow Emily C. Maggioncalda Eric L. Nuermberger Gyanu Lamichhane Craig A. Townsend Development of a penem antibiotic against Mycobacteroides abscessus
description	Batchelder et al. report a new penem class antibiotic, T405, which exhibits potent activity against M. abscessus and clinical isolates from cystic fibrosis patients. The development of resistance to T405 is inhibited with the addition of a β-lactamase inhibitor, avibactam. Its clinical potential is further demonstrated by T405 displaying a favourable pharmacokinetic profile in mice with an absence of toxicity.
format	article
author	Hunter R. Batchelder Elizabeth Story-Roller Evan P. Lloyd Amit Kaushik Kristina M. Bigelow Emily C. Maggioncalda Eric L. Nuermberger Gyanu Lamichhane Craig A. Townsend
author_facet	Hunter R. Batchelder Elizabeth Story-Roller Evan P. Lloyd Amit Kaushik Kristina M. Bigelow Emily C. Maggioncalda Eric L. Nuermberger Gyanu Lamichhane Craig A. Townsend
author_sort	Hunter R. Batchelder
title	Development of a penem antibiotic against Mycobacteroides abscessus
title_short	Development of a penem antibiotic against Mycobacteroides abscessus
title_full	Development of a penem antibiotic against Mycobacteroides abscessus
title_fullStr	Development of a penem antibiotic against Mycobacteroides abscessus
title_full_unstemmed	Development of a penem antibiotic against Mycobacteroides abscessus
title_sort	development of a penem antibiotic against mycobacteroides abscessus
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5e507dd0a49447c7b96b6dc7becd6906
work_keys_str_mv	AT hunterrbatchelder developmentofapenemantibioticagainstmycobacteroidesabscessus AT elizabethstoryroller developmentofapenemantibioticagainstmycobacteroidesabscessus AT evanplloyd developmentofapenemantibioticagainstmycobacteroidesabscessus AT amitkaushik developmentofapenemantibioticagainstmycobacteroidesabscessus AT kristinambigelow developmentofapenemantibioticagainstmycobacteroidesabscessus AT emilycmaggioncalda developmentofapenemantibioticagainstmycobacteroidesabscessus AT ericlnuermberger developmentofapenemantibioticagainstmycobacteroidesabscessus AT gyanulamichhane developmentofapenemantibioticagainstmycobacteroidesabscessus AT craigatownsend developmentofapenemantibioticagainstmycobacteroidesabscessus
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Development of a penem antibiotic against Mycobacteroides abscessus

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