UCH-L1 and UCH-L3 regulate the cancer stem cell-like properties through PI3 K/Akt signaling pathway in prostate cancer cells

Castration-resistant prostate cancer (CRPC) is a highly aggressive and advanced prostate cancer that is currently incurable with conventional therapies. The recurrence and chemotherapy-resistant properties of CRPC are attributed to prostate cancer stem cells (CSCs). On the other hand, the factors re...

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Autores principales:	Jae Eun Lee, Yun Hwan Lim, Jung Hwa Kim
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	uch-l1 uch-l3 csc-like property pi3 k/akt signaling pathway Medicine (General) R5-920 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5e5244c04f5543fab8b89fdcf0d5853b
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spelling	oai:doaj.org-article:5e5244c04f5543fab8b89fdcf0d5853b2021-11-04T15:00:42ZUCH-L1 and UCH-L3 regulate the cancer stem cell-like properties through PI3 K/Akt signaling pathway in prostate cancer cells1976-83542151-248510.1080/19768354.2021.1987320https://doaj.org/article/5e5244c04f5543fab8b89fdcf0d5853b2021-09-01T00:00:00Zhttp://dx.doi.org/10.1080/19768354.2021.1987320https://doaj.org/toc/1976-8354https://doaj.org/toc/2151-2485Castration-resistant prostate cancer (CRPC) is a highly aggressive and advanced prostate cancer that is currently incurable with conventional therapies. The recurrence and chemotherapy-resistant properties of CRPC are attributed to prostate cancer stem cells (CSCs). On the other hand, the factors regulating the prostate CSC-like properties have not been studied extensively. Previously, ubiquitin C-terminal hydrolase-L1 (UCH-L1) and ubiquitin C-terminal hydrolase-L3 (UCH-L3) were reported to be involved in prostate cancer cell progression through the epithelial-to-mesenchymal transition (EMT) regulation. Here, the differential regulation on the CSC-like properties by UCH-L1 and UCH-L3 were identified in prostate cancer cells. The CSC-like characteristics, such as the expression of pluripotency markers, chemoresistance, and sphere-forming ability, were promoted by UCH-L1, whereas those were repressed by UCH-L3. Moreover, the modulation of CSC-like properties by UCH-L1 and UCH-L3 was through the PI3 K/Akt signaling pathway. The CSC-like properties induced by UCH-L1 overexpression or UCH-L3 depletion were suppressed by the PI3 K/Akt pathway inhibitor. In conclusion, UCH-L1 and UCH-L3 are novel regulators of the CSC-like properties and shed light on new therapeutic strategies to overcome CSCs in prostate cancers.Jae Eun LeeYun Hwan LimJung Hwa KimTaylor & Francis Grouparticleuch-l1uch-l3csc-like propertypi3 k/akt signaling pathwayMedicine (General)R5-920Biology (General)QH301-705.5ENAnimal Cells and Systems, Vol 25, Iss 5, Pp 312-322 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	uch-l1 uch-l3 csc-like property pi3 k/akt signaling pathway Medicine (General) R5-920 Biology (General) QH301-705.5
spellingShingle	uch-l1 uch-l3 csc-like property pi3 k/akt signaling pathway Medicine (General) R5-920 Biology (General) QH301-705.5 Jae Eun Lee Yun Hwan Lim Jung Hwa Kim UCH-L1 and UCH-L3 regulate the cancer stem cell-like properties through PI3 K/Akt signaling pathway in prostate cancer cells
description	Castration-resistant prostate cancer (CRPC) is a highly aggressive and advanced prostate cancer that is currently incurable with conventional therapies. The recurrence and chemotherapy-resistant properties of CRPC are attributed to prostate cancer stem cells (CSCs). On the other hand, the factors regulating the prostate CSC-like properties have not been studied extensively. Previously, ubiquitin C-terminal hydrolase-L1 (UCH-L1) and ubiquitin C-terminal hydrolase-L3 (UCH-L3) were reported to be involved in prostate cancer cell progression through the epithelial-to-mesenchymal transition (EMT) regulation. Here, the differential regulation on the CSC-like properties by UCH-L1 and UCH-L3 were identified in prostate cancer cells. The CSC-like characteristics, such as the expression of pluripotency markers, chemoresistance, and sphere-forming ability, were promoted by UCH-L1, whereas those were repressed by UCH-L3. Moreover, the modulation of CSC-like properties by UCH-L1 and UCH-L3 was through the PI3 K/Akt signaling pathway. The CSC-like properties induced by UCH-L1 overexpression or UCH-L3 depletion were suppressed by the PI3 K/Akt pathway inhibitor. In conclusion, UCH-L1 and UCH-L3 are novel regulators of the CSC-like properties and shed light on new therapeutic strategies to overcome CSCs in prostate cancers.
format	article
author	Jae Eun Lee Yun Hwan Lim Jung Hwa Kim
author_facet	Jae Eun Lee Yun Hwan Lim Jung Hwa Kim
author_sort	Jae Eun Lee
title	UCH-L1 and UCH-L3 regulate the cancer stem cell-like properties through PI3 K/Akt signaling pathway in prostate cancer cells
title_short	UCH-L1 and UCH-L3 regulate the cancer stem cell-like properties through PI3 K/Akt signaling pathway in prostate cancer cells
title_full	UCH-L1 and UCH-L3 regulate the cancer stem cell-like properties through PI3 K/Akt signaling pathway in prostate cancer cells
title_fullStr	UCH-L1 and UCH-L3 regulate the cancer stem cell-like properties through PI3 K/Akt signaling pathway in prostate cancer cells
title_full_unstemmed	UCH-L1 and UCH-L3 regulate the cancer stem cell-like properties through PI3 K/Akt signaling pathway in prostate cancer cells
title_sort	uch-l1 and uch-l3 regulate the cancer stem cell-like properties through pi3 k/akt signaling pathway in prostate cancer cells
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/5e5244c04f5543fab8b89fdcf0d5853b
work_keys_str_mv	AT jaeeunlee uchl1anduchl3regulatethecancerstemcelllikepropertiesthroughpi3kaktsignalingpathwayinprostatecancercells AT yunhwanlim uchl1anduchl3regulatethecancerstemcelllikepropertiesthroughpi3kaktsignalingpathwayinprostatecancercells AT junghwakim uchl1anduchl3regulatethecancerstemcelllikepropertiesthroughpi3kaktsignalingpathwayinprostatecancercells
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UCH-L1 and UCH-L3 regulate the cancer stem cell-like properties through PI3 K/Akt signaling pathway in prostate cancer cells

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