Loss of Ahi1 impairs neurotransmitter release and causes depressive behaviors in mice.

Major depression is becoming one of the most prevalent forms of psychiatric disorders. However, the mechanisms of major depression are still not well-understood. Most antidepressants are only effective in some patients and produce some serious side effects. Animal models of depression are therefore...

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Autores principales:	Liyan Ren, Xuanchen Qian, Lijing Zhai, Miao Sun, Zhigang Miao, Jizhen Li, Xingshun Xu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5e524917c6044d3e80716e328a22ce87
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spelling	oai:doaj.org-article:5e524917c6044d3e80716e328a22ce872021-11-18T08:25:32ZLoss of Ahi1 impairs neurotransmitter release and causes depressive behaviors in mice.1932-620310.1371/journal.pone.0093640https://doaj.org/article/5e524917c6044d3e80716e328a22ce872014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24691070/?tool=EBIhttps://doaj.org/toc/1932-6203Major depression is becoming one of the most prevalent forms of psychiatric disorders. However, the mechanisms of major depression are still not well-understood. Most antidepressants are only effective in some patients and produce some serious side effects. Animal models of depression are therefore essential to unravel the mechanisms of depression and to develop novel therapeutic strategies. Our previous studies showed that Abelson helper integration site-1 (Ahi1) deficiency causes depression-like behaviors in mice. In this study, we characterized the biochemical and behavioral changes in Ahi1 knockout (KO) mice. In Ahi1 KO mice, neurotransmitters including serotonin and dopamine were significantly decreased in different brain regions. However, glutamate and GABA levels were not affected by Ahi1 deficiency. The antidepressant imipramine attenuated depressive behaviors and partially restored brain serotonin level in Ahi1 KO mice. Our findings suggest that Ahi1 KO mice can be used for studying the mechanisms of depression and screening therapeutic targets.Liyan RenXuanchen QianLijing ZhaiMiao SunZhigang MiaoJizhen LiXingshun XuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 4, p e93640 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Liyan Ren Xuanchen Qian Lijing Zhai Miao Sun Zhigang Miao Jizhen Li Xingshun Xu Loss of Ahi1 impairs neurotransmitter release and causes depressive behaviors in mice.
description	Major depression is becoming one of the most prevalent forms of psychiatric disorders. However, the mechanisms of major depression are still not well-understood. Most antidepressants are only effective in some patients and produce some serious side effects. Animal models of depression are therefore essential to unravel the mechanisms of depression and to develop novel therapeutic strategies. Our previous studies showed that Abelson helper integration site-1 (Ahi1) deficiency causes depression-like behaviors in mice. In this study, we characterized the biochemical and behavioral changes in Ahi1 knockout (KO) mice. In Ahi1 KO mice, neurotransmitters including serotonin and dopamine were significantly decreased in different brain regions. However, glutamate and GABA levels were not affected by Ahi1 deficiency. The antidepressant imipramine attenuated depressive behaviors and partially restored brain serotonin level in Ahi1 KO mice. Our findings suggest that Ahi1 KO mice can be used for studying the mechanisms of depression and screening therapeutic targets.
format	article
author	Liyan Ren Xuanchen Qian Lijing Zhai Miao Sun Zhigang Miao Jizhen Li Xingshun Xu
author_facet	Liyan Ren Xuanchen Qian Lijing Zhai Miao Sun Zhigang Miao Jizhen Li Xingshun Xu
author_sort	Liyan Ren
title	Loss of Ahi1 impairs neurotransmitter release and causes depressive behaviors in mice.
title_short	Loss of Ahi1 impairs neurotransmitter release and causes depressive behaviors in mice.
title_full	Loss of Ahi1 impairs neurotransmitter release and causes depressive behaviors in mice.
title_fullStr	Loss of Ahi1 impairs neurotransmitter release and causes depressive behaviors in mice.
title_full_unstemmed	Loss of Ahi1 impairs neurotransmitter release and causes depressive behaviors in mice.
title_sort	loss of ahi1 impairs neurotransmitter release and causes depressive behaviors in mice.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/5e524917c6044d3e80716e328a22ce87
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_version_	1718421803609620480

Loss of Ahi1 impairs neurotransmitter release and causes depressive behaviors in mice.

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