Give me a pain that I am used to: distinct habituation patterns to painful and non-painful stimulation

Abstract Pain habituation is associated with a decrease of activation in brain areas related to pain perception. However, little is known about the specificity of these decreases to pain, as habituation has also been described for other responses like spinal reflexes and other sensory responses. Thu...

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Autores principales:	Katharina Paul, Martin Tik, Andreas Hahn, Ronald Sladky, Nicole Geissberger, Eva-Maria Wirth, Georg S. Kranz, Daniela M. Pfabigan, Christoph Kraus, Rupert Lanzenberger, Claus Lamm, Christian Windischberger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5e533ee61cb04227b27158eebdc2491c
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spelling	oai:doaj.org-article:5e533ee61cb04227b27158eebdc2491c2021-11-28T12:15:59ZGive me a pain that I am used to: distinct habituation patterns to painful and non-painful stimulation10.1038/s41598-021-01881-42045-2322https://doaj.org/article/5e533ee61cb04227b27158eebdc2491c2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01881-4https://doaj.org/toc/2045-2322Abstract Pain habituation is associated with a decrease of activation in brain areas related to pain perception. However, little is known about the specificity of these decreases to pain, as habituation has also been described for other responses like spinal reflexes and other sensory responses. Thus, it might be hypothesized that previously reported reductions in activation are not specifically related to pain habituation. For this reason, we performed a 3 T fMRI study using either painful or non-painful electrical stimulation via an electrode attached to the back of the left hand. Contrasting painful vs. non-painful stimulation revealed significant activation clusters in regions well-known to be related to pain processing, such as bilateral anterior and posterior insula, primary/secondary sensory cortices (S1/S2) and anterior midcingulate cortex (aMCC). Importantly, our results show distinct habituation patterns for painful (in aMCC) and non-painful (contralateral claustrum) stimulation, while similar habituation for both types of stimulation was identified in bilateral inferior frontal gyrus (IFG) and contralateral S2. Our findings thus distinguish a general habituation in somatosensory processing (S2) and reduced attention (IFG) from specific pain and non-pain related habituation effects where pain-specific habituation effects within the aMCC highlight a change in affective pain perception.Katharina PaulMartin TikAndreas HahnRonald SladkyNicole GeissbergerEva-Maria WirthGeorg S. KranzDaniela M. PfabiganChristoph KrausRupert LanzenbergerClaus LammChristian WindischbergerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katharina Paul Martin Tik Andreas Hahn Ronald Sladky Nicole Geissberger Eva-Maria Wirth Georg S. Kranz Daniela M. Pfabigan Christoph Kraus Rupert Lanzenberger Claus Lamm Christian Windischberger Give me a pain that I am used to: distinct habituation patterns to painful and non-painful stimulation
description	Abstract Pain habituation is associated with a decrease of activation in brain areas related to pain perception. However, little is known about the specificity of these decreases to pain, as habituation has also been described for other responses like spinal reflexes and other sensory responses. Thus, it might be hypothesized that previously reported reductions in activation are not specifically related to pain habituation. For this reason, we performed a 3 T fMRI study using either painful or non-painful electrical stimulation via an electrode attached to the back of the left hand. Contrasting painful vs. non-painful stimulation revealed significant activation clusters in regions well-known to be related to pain processing, such as bilateral anterior and posterior insula, primary/secondary sensory cortices (S1/S2) and anterior midcingulate cortex (aMCC). Importantly, our results show distinct habituation patterns for painful (in aMCC) and non-painful (contralateral claustrum) stimulation, while similar habituation for both types of stimulation was identified in bilateral inferior frontal gyrus (IFG) and contralateral S2. Our findings thus distinguish a general habituation in somatosensory processing (S2) and reduced attention (IFG) from specific pain and non-pain related habituation effects where pain-specific habituation effects within the aMCC highlight a change in affective pain perception.
format	article
author	Katharina Paul Martin Tik Andreas Hahn Ronald Sladky Nicole Geissberger Eva-Maria Wirth Georg S. Kranz Daniela M. Pfabigan Christoph Kraus Rupert Lanzenberger Claus Lamm Christian Windischberger
author_facet	Katharina Paul Martin Tik Andreas Hahn Ronald Sladky Nicole Geissberger Eva-Maria Wirth Georg S. Kranz Daniela M. Pfabigan Christoph Kraus Rupert Lanzenberger Claus Lamm Christian Windischberger
author_sort	Katharina Paul
title	Give me a pain that I am used to: distinct habituation patterns to painful and non-painful stimulation
title_short	Give me a pain that I am used to: distinct habituation patterns to painful and non-painful stimulation
title_full	Give me a pain that I am used to: distinct habituation patterns to painful and non-painful stimulation
title_fullStr	Give me a pain that I am used to: distinct habituation patterns to painful and non-painful stimulation
title_full_unstemmed	Give me a pain that I am used to: distinct habituation patterns to painful and non-painful stimulation
title_sort	give me a pain that i am used to: distinct habituation patterns to painful and non-painful stimulation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5e533ee61cb04227b27158eebdc2491c
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Give me a pain that I am used to: distinct habituation patterns to painful and non-painful stimulation

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