Response to Levetiracetam Treatment and Long-Term Follow-Up in Dogs With Reactive Seizures Due to Probable Exogenous Toxicity

Limited information is available on the long-term follow-up and seizure recurrence in dogs with reactive seizures due to suspected exogenous toxicity. The purpose of this study was to report the long-term follow-up of 13 dogs referred to a single referral hospital, diagnosed with reactive seizures a...

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Autores principales:	Fabio Stabile, Luisa De Risio
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	reactive seizures levetiracetam intoxication long-term follow-up canine epilepsy Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/5e5590f4d79a43dd91a06743a6a2e60a
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spelling	oai:doaj.org-article:5e5590f4d79a43dd91a06743a6a2e60a2021-11-15T04:49:09ZResponse to Levetiracetam Treatment and Long-Term Follow-Up in Dogs With Reactive Seizures Due to Probable Exogenous Toxicity2297-176910.3389/fvets.2021.773942https://doaj.org/article/5e5590f4d79a43dd91a06743a6a2e60a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fvets.2021.773942/fullhttps://doaj.org/toc/2297-1769Limited information is available on the long-term follow-up and seizure recurrence in dogs with reactive seizures due to suspected exogenous toxicity. The purpose of this study was to report the long-term follow-up of 13 dogs referred to a single referral hospital, diagnosed with reactive seizures and treated with a standardized levetiracetam protocol. All dogs received a loading levetiracetam dose of 60 mg/kg/IV once, followed by a maintenance dose of 20 mg/kg every 8 h as part of an open-label clinical study. Levetiracetam was withdrawn after a 6-months seizure-free period by reducing levetiracetam to 20 mg/kg every 12 h for a 4-week seizure-free period, followed by levetiracetam 20 mg/kg every 24 h for a 4-week seizure-free period, before levetiracetam treatment was stopped. No adverse effects of the treatment were reported. No dogs experienced any seizures after discharge or after levetiracetam withdrawal. Median follow-up time from time of discharge was of 78 months (=6 years 6 months). The result of this study supports the use of levetiracetam for treatment of reactive seizures due to exogenous substance intoxication. Moreover, our results do not support the need for long-term antiepileptic treatment in cases of reactive seizures due to exogenous intoxication.Fabio StabileLuisa De RisioFrontiers Media S.A.articlereactive seizureslevetiracetamintoxicationlong-term follow-upcanine epilepsyVeterinary medicineSF600-1100ENFrontiers in Veterinary Science, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	reactive seizures levetiracetam intoxication long-term follow-up canine epilepsy Veterinary medicine SF600-1100
spellingShingle	reactive seizures levetiracetam intoxication long-term follow-up canine epilepsy Veterinary medicine SF600-1100 Fabio Stabile Luisa De Risio Response to Levetiracetam Treatment and Long-Term Follow-Up in Dogs With Reactive Seizures Due to Probable Exogenous Toxicity
description	Limited information is available on the long-term follow-up and seizure recurrence in dogs with reactive seizures due to suspected exogenous toxicity. The purpose of this study was to report the long-term follow-up of 13 dogs referred to a single referral hospital, diagnosed with reactive seizures and treated with a standardized levetiracetam protocol. All dogs received a loading levetiracetam dose of 60 mg/kg/IV once, followed by a maintenance dose of 20 mg/kg every 8 h as part of an open-label clinical study. Levetiracetam was withdrawn after a 6-months seizure-free period by reducing levetiracetam to 20 mg/kg every 12 h for a 4-week seizure-free period, followed by levetiracetam 20 mg/kg every 24 h for a 4-week seizure-free period, before levetiracetam treatment was stopped. No adverse effects of the treatment were reported. No dogs experienced any seizures after discharge or after levetiracetam withdrawal. Median follow-up time from time of discharge was of 78 months (=6 years 6 months). The result of this study supports the use of levetiracetam for treatment of reactive seizures due to exogenous substance intoxication. Moreover, our results do not support the need for long-term antiepileptic treatment in cases of reactive seizures due to exogenous intoxication.
format	article
author	Fabio Stabile Luisa De Risio
author_facet	Fabio Stabile Luisa De Risio
author_sort	Fabio Stabile
title	Response to Levetiracetam Treatment and Long-Term Follow-Up in Dogs With Reactive Seizures Due to Probable Exogenous Toxicity
title_short	Response to Levetiracetam Treatment and Long-Term Follow-Up in Dogs With Reactive Seizures Due to Probable Exogenous Toxicity
title_full	Response to Levetiracetam Treatment and Long-Term Follow-Up in Dogs With Reactive Seizures Due to Probable Exogenous Toxicity
title_fullStr	Response to Levetiracetam Treatment and Long-Term Follow-Up in Dogs With Reactive Seizures Due to Probable Exogenous Toxicity
title_full_unstemmed	Response to Levetiracetam Treatment and Long-Term Follow-Up in Dogs With Reactive Seizures Due to Probable Exogenous Toxicity
title_sort	response to levetiracetam treatment and long-term follow-up in dogs with reactive seizures due to probable exogenous toxicity
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/5e5590f4d79a43dd91a06743a6a2e60a
work_keys_str_mv	AT fabiostabile responsetolevetiracetamtreatmentandlongtermfollowupindogswithreactiveseizuresduetoprobableexogenoustoxicity AT luisaderisio responsetolevetiracetamtreatmentandlongtermfollowupindogswithreactiveseizuresduetoprobableexogenoustoxicity
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Response to Levetiracetam Treatment and Long-Term Follow-Up in Dogs With Reactive Seizures Due to Probable Exogenous Toxicity

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