Peptide signaling without feedback in signal production operates as a true quorum sensing communication system in Bacillus subtilis

Iztok Dogsa et al. use mathematical modeling and experimental approaches to investigate how the ComQXPA communication system in Bacillus subtilis initiate a quorum-sensing response without the positive feedback loop dependent on signal molecules seen in many systems. They find that the peptide ComX...

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Autores principales:	Iztok Dogsa, Mihael Spacapan, Anna Dragoš, Tjaša Danevčič, Žiga Pandur, Ines Mandic-Mulec
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5e5a6df5369148f7b65aeb5316a7bb9e
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spelling	oai:doaj.org-article:5e5a6df5369148f7b65aeb5316a7bb9e2021-12-02T15:13:13ZPeptide signaling without feedback in signal production operates as a true quorum sensing communication system in Bacillus subtilis10.1038/s42003-020-01553-52399-3642https://doaj.org/article/5e5a6df5369148f7b65aeb5316a7bb9e2021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01553-5https://doaj.org/toc/2399-3642Iztok Dogsa et al. use mathematical modeling and experimental approaches to investigate how the ComQXPA communication system in Bacillus subtilis initiate a quorum-sensing response without the positive feedback loop dependent on signal molecules seen in many systems. They find that the peptide ComX encodes information about cell density, specific cell growth rate and oxygen concentration, which ensure power-law increase in signal molecule production and enables a sharp transition in gene expression level without the typical feedback loop.Iztok DogsaMihael SpacapanAnna DragošTjaša DanevčičŽiga PandurInes Mandic-MulecNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Iztok Dogsa Mihael Spacapan Anna Dragoš Tjaša Danevčič Žiga Pandur Ines Mandic-Mulec Peptide signaling without feedback in signal production operates as a true quorum sensing communication system in Bacillus subtilis
description	Iztok Dogsa et al. use mathematical modeling and experimental approaches to investigate how the ComQXPA communication system in Bacillus subtilis initiate a quorum-sensing response without the positive feedback loop dependent on signal molecules seen in many systems. They find that the peptide ComX encodes information about cell density, specific cell growth rate and oxygen concentration, which ensure power-law increase in signal molecule production and enables a sharp transition in gene expression level without the typical feedback loop.
format	article
author	Iztok Dogsa Mihael Spacapan Anna Dragoš Tjaša Danevčič Žiga Pandur Ines Mandic-Mulec
author_facet	Iztok Dogsa Mihael Spacapan Anna Dragoš Tjaša Danevčič Žiga Pandur Ines Mandic-Mulec
author_sort	Iztok Dogsa
title	Peptide signaling without feedback in signal production operates as a true quorum sensing communication system in Bacillus subtilis
title_short	Peptide signaling without feedback in signal production operates as a true quorum sensing communication system in Bacillus subtilis
title_full	Peptide signaling without feedback in signal production operates as a true quorum sensing communication system in Bacillus subtilis
title_fullStr	Peptide signaling without feedback in signal production operates as a true quorum sensing communication system in Bacillus subtilis
title_full_unstemmed	Peptide signaling without feedback in signal production operates as a true quorum sensing communication system in Bacillus subtilis
title_sort	peptide signaling without feedback in signal production operates as a true quorum sensing communication system in bacillus subtilis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5e5a6df5369148f7b65aeb5316a7bb9e
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Peptide signaling without feedback in signal production operates as a true quorum sensing communication system in Bacillus subtilis

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