Redox imbalance is related to HIV and pregnancy.

Redox imbalance may compromise the homeostasis of physiological processes indispensable to gestational development in HIV-infected women. The present study aims to evaluate markers of the redox system in the development of pregnancy of these women. HIV-positive pregnant women, HIV-negative pregnant...

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Autores principales:	Vanessa Martinez Manfio, Karen Ingrid Tasca, Jessica Leite Garcia, Janaina de Oliveira Góis, Camila Renata Correa, Lenice do Rosário de Souza
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5e5f3fc430a249bbae9cb03c459e2a90
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spelling	oai:doaj.org-article:5e5f3fc430a249bbae9cb03c459e2a902021-11-25T05:54:15ZRedox imbalance is related to HIV and pregnancy.1932-620310.1371/journal.pone.0251619https://doaj.org/article/5e5f3fc430a249bbae9cb03c459e2a902021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251619https://doaj.org/toc/1932-6203Redox imbalance may compromise the homeostasis of physiological processes indispensable to gestational development in HIV-infected women. The present study aims to evaluate markers of the redox system in the development of pregnancy of these women. HIV-positive pregnant women, HIV-negative pregnant women and non-pregnant were studied. Redox markers superoxide dismutase (SOD), catalase (CAT), protein carbonylation and malondialdehyde (MDA) were assessed at first or second trimester, third trimester and postpartum from pregnant and from non-pregnant women. According to the longitudinal analysis model, CAT activity was increased in the postpartum in HIV-positive women and before delivery in HIV-negative women. Increased carbonylation was observed in the pre-delivery period of HIV-negative pregnant women and MDA concentrations were higher in HIV-positive pregnant women compared to those non-infected by HIV at all times. According to the factorial model, higher SOD and CAT activities were observed in HIV-positive women in the initial months of pregnancy and in non-pregnant women. Carbonylation at third trimester was more evident in HIV-negative pregnant women. MDA levels were higher in HIV-positive pregnant women. Increased oxidative stress may occur in HIV-infected pregnant women. Nevertheless, the HIV virus is not solely responsible for this process; instead, mechanisms inherent to the pregnancy seem to play a role in this imbalance.Vanessa Martinez ManfioKaren Ingrid TascaJessica Leite GarciaJanaina de Oliveira GóisCamila Renata CorreaLenice do Rosário de SouzaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251619 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vanessa Martinez Manfio Karen Ingrid Tasca Jessica Leite Garcia Janaina de Oliveira Góis Camila Renata Correa Lenice do Rosário de Souza Redox imbalance is related to HIV and pregnancy.
description	Redox imbalance may compromise the homeostasis of physiological processes indispensable to gestational development in HIV-infected women. The present study aims to evaluate markers of the redox system in the development of pregnancy of these women. HIV-positive pregnant women, HIV-negative pregnant women and non-pregnant were studied. Redox markers superoxide dismutase (SOD), catalase (CAT), protein carbonylation and malondialdehyde (MDA) were assessed at first or second trimester, third trimester and postpartum from pregnant and from non-pregnant women. According to the longitudinal analysis model, CAT activity was increased in the postpartum in HIV-positive women and before delivery in HIV-negative women. Increased carbonylation was observed in the pre-delivery period of HIV-negative pregnant women and MDA concentrations were higher in HIV-positive pregnant women compared to those non-infected by HIV at all times. According to the factorial model, higher SOD and CAT activities were observed in HIV-positive women in the initial months of pregnancy and in non-pregnant women. Carbonylation at third trimester was more evident in HIV-negative pregnant women. MDA levels were higher in HIV-positive pregnant women. Increased oxidative stress may occur in HIV-infected pregnant women. Nevertheless, the HIV virus is not solely responsible for this process; instead, mechanisms inherent to the pregnancy seem to play a role in this imbalance.
format	article
author	Vanessa Martinez Manfio Karen Ingrid Tasca Jessica Leite Garcia Janaina de Oliveira Góis Camila Renata Correa Lenice do Rosário de Souza
author_facet	Vanessa Martinez Manfio Karen Ingrid Tasca Jessica Leite Garcia Janaina de Oliveira Góis Camila Renata Correa Lenice do Rosário de Souza
author_sort	Vanessa Martinez Manfio
title	Redox imbalance is related to HIV and pregnancy.
title_short	Redox imbalance is related to HIV and pregnancy.
title_full	Redox imbalance is related to HIV and pregnancy.
title_fullStr	Redox imbalance is related to HIV and pregnancy.
title_full_unstemmed	Redox imbalance is related to HIV and pregnancy.
title_sort	redox imbalance is related to hiv and pregnancy.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/5e5f3fc430a249bbae9cb03c459e2a90
work_keys_str_mv	AT vanessamartinezmanfio redoximbalanceisrelatedtohivandpregnancy AT kareningridtasca redoximbalanceisrelatedtohivandpregnancy AT jessicaleitegarcia redoximbalanceisrelatedtohivandpregnancy AT janainadeoliveiragois redoximbalanceisrelatedtohivandpregnancy AT camilarenatacorrea redoximbalanceisrelatedtohivandpregnancy AT lenicedorosariodesouza redoximbalanceisrelatedtohivandpregnancy
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Redox imbalance is related to HIV and pregnancy.

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