Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23

Invariant Natural Killer T cells (iNKT) rapidly exert effector functions upon activation, but the mechanisms of their functional maturation remain to be determined. Here, Xu and colleagues show that the mediator subunit Med23 is a transcriptional regulator controlling iNKT cell terminal maturation.

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Autores principales:	Yu Xu, Yang Sun, Hao Shen, Yuling Dai, Haifeng Liu, Ronghong Li, Hongdao Zhang, Ligang Wu, Xiaoyan Zhu, Xiaolong Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5e62ecc2f81c4eb2a9fd45b61b5a8c9d
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spelling	oai:doaj.org-article:5e62ecc2f81c4eb2a9fd45b61b5a8c9d2021-12-02T17:31:15ZRegulation of the terminal maturation of iNKT cells by mediator complex subunit 2310.1038/s41467-018-06372-12041-1723https://doaj.org/article/5e62ecc2f81c4eb2a9fd45b61b5a8c9d2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06372-1https://doaj.org/toc/2041-1723Invariant Natural Killer T cells (iNKT) rapidly exert effector functions upon activation, but the mechanisms of their functional maturation remain to be determined. Here, Xu and colleagues show that the mediator subunit Med23 is a transcriptional regulator controlling iNKT cell terminal maturation.Yu XuYang SunHao ShenYuling DaiHaifeng LiuRonghong LiHongdao ZhangLigang WuXiaoyan ZhuXiaolong LiuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yu Xu Yang Sun Hao Shen Yuling Dai Haifeng Liu Ronghong Li Hongdao Zhang Ligang Wu Xiaoyan Zhu Xiaolong Liu Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23
description	Invariant Natural Killer T cells (iNKT) rapidly exert effector functions upon activation, but the mechanisms of their functional maturation remain to be determined. Here, Xu and colleagues show that the mediator subunit Med23 is a transcriptional regulator controlling iNKT cell terminal maturation.
format	article
author	Yu Xu Yang Sun Hao Shen Yuling Dai Haifeng Liu Ronghong Li Hongdao Zhang Ligang Wu Xiaoyan Zhu Xiaolong Liu
author_facet	Yu Xu Yang Sun Hao Shen Yuling Dai Haifeng Liu Ronghong Li Hongdao Zhang Ligang Wu Xiaoyan Zhu Xiaolong Liu
author_sort	Yu Xu
title	Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23
title_short	Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23
title_full	Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23
title_fullStr	Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23
title_full_unstemmed	Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23
title_sort	regulation of the terminal maturation of inkt cells by mediator complex subunit 23
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5e62ecc2f81c4eb2a9fd45b61b5a8c9d
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Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23

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